Acidosis and alkali therapy in patients with kidney transplant is associated with transcriptional changes and altered abundance of genes involved in cell metabolism and acid-base balance.

Publication

Acidosis and alkali therapy in patients with kidney transplant is associated with transcriptional changes and altered abundance of genes involved in cell metabolism and acid-base balance.

Journal Paper/Review - Sep 27, 2021

Imenez Silva Pedro H, Wiegand Anna, Daryadel Arezoo, Russo Giancarlo, Ritter Alexander, Gaspert Ariana, Wüthrich Rudolf P, Wagner Carsten A, Mohebbi Nilufar

Citation

Imenez Silva P, Wiegand A, Daryadel A, Russo G, Ritter A, Gaspert A, Wüthrich R, Wagner C, Mohebbi N. Acidosis and alkali therapy in patients with kidney transplant is associated with transcriptional changes and altered abundance of genes involved in cell metabolism and acid-base balance. Nephrol Dial Transplant 2021; 36:1806-1820.

Type

Journal Paper/Review (English)

Journal

Nephrol Dial Transplant 2021; 36

Publication Date

Sep 27, 2021

Issn Electronic

1460-2385

Pages

1806-1820

Brief description/objective

Metabolic acidosis occurs frequently in patients with kidney transplant and is associated with a higher risk for and accelerated loss of graft function. To date, it is not known whether alkali therapy in these patients improves kidney function and whether acidosis and its therapy are associated with altered expression of proteins involved in renal acid-base metabolism.