MicroRNA-regulated pathways of flow-stimulated angiogenesis and vascular remodeling in vivo.

Publikation

MicroRNA-regulated pathways of flow-stimulated angiogenesis and vascular remodeling in vivo.

Wissenschaftlicher Artikel/Review - 11.01.2019

Henn Dominic, Abu-Halima Masood, Wermke Dominik, Falkner Florian, Thomas Benjamin, Köpple Christoph, Ludwig Nicole, Schulte Matthias, Brockmann Marc A, Kim Yoo-Jin, Sacks Justin M, Kneser Ulrich, Keller Andreas, Meese Eckart, Schmidt Volker

Zitation

Henn D, Abu-Halima M, Wermke D, Falkner F, Thomas B, Köpple C, Ludwig N, Schulte M, Brockmann M, Kim Y, Sacks J, Kneser U, Keller A, Meese E, Schmidt V. MicroRNA-regulated pathways of flow-stimulated angiogenesis and vascular remodeling in vivo. J Transl Med 2019; 17:22.

Art

Wissenschaftlicher Artikel/Review (Englisch)

Zeitschrift

J Transl Med 2019; 17

Veröffentlichungsdatum

11.01.2019

eISSN (Online)

1479-5876

Seiten

Kurzbeschreibung/Zielsetzung

Vascular shear stress promotes endothelial cell sprouting in vitro. The impact of hemodynamic forces on microRNA (miRNA) and gene expression within growing vascular networks in vivo, however, remain poorly investigated. Arteriovenous (AV) shunts are an established model for induction of neoangiogenesis in vivo and can serve as a tool for analysis of hemodynamic effects on miRNA and gene expression profiles over time.