MicroRNA-regulated pathways of flow-stimulated angiogenesis and vascular remodeling in vivo.

Publication

MicroRNA-regulated pathways of flow-stimulated angiogenesis and vascular remodeling in vivo.

Journal Paper/Review - Jan 11, 2019

Henn Dominic, Abu-Halima Masood, Wermke Dominik, Falkner Florian, Thomas Benjamin, Köpple Christoph, Ludwig Nicole, Schulte Matthias, Brockmann Marc A, Kim Yoo-Jin, Sacks Justin M, Kneser Ulrich, Keller Andreas, Meese Eckart, Schmidt Volker

Citation

Henn D, Abu-Halima M, Wermke D, Falkner F, Thomas B, Köpple C, Ludwig N, Schulte M, Brockmann M, Kim Y, Sacks J, Kneser U, Keller A, Meese E, Schmidt V. MicroRNA-regulated pathways of flow-stimulated angiogenesis and vascular remodeling in vivo. J Transl Med 2019; 17:22.

Type

Journal Paper/Review (English)

Journal

J Transl Med 2019; 17

Publication Date

Jan 11, 2019

Issn Electronic

1479-5876

Brief description/objective

Vascular shear stress promotes endothelial cell sprouting in vitro. The impact of hemodynamic forces on microRNA (miRNA) and gene expression within growing vascular networks in vivo, however, remain poorly investigated. Arteriovenous (AV) shunts are an established model for induction of neoangiogenesis in vivo and can serve as a tool for analysis of hemodynamic effects on miRNA and gene expression profiles over time.