Impact of tumor volume and systemic therapy on outcome in patients undergoing IMRT for large volume head neck cancer.

Publikation

Impact of tumor volume and systemic therapy on outcome in patients undergoing IMRT for large volume head neck cancer.

Wissenschaftlicher Artikel/Review - 22.09.2011

Studer Gabriela, Rordorf Tamara, Glanzmann Christoph

Zitation

Studer G, Rordorf T, Glanzmann C. Impact of tumor volume and systemic therapy on outcome in patients undergoing IMRT for large volume head neck cancer. Radiat Oncol 2011; 6:120.

Art

Wissenschaftlicher Artikel/Review (Englisch)

Zeitschrift

Radiat Oncol 2011; 6

Veröffentlichungsdatum

22.09.2011

eISSN (Online)

1748-717X

Seiten

120

Kurzbeschreibung/Zielsetzung

Former prospective analyses revealed gross tumor volume (GTV) as the most reliable parameter to statistically significantly predict disease control in head neck cancer (HNC) patients treated with definitive intensity modulated radiation therapy (IMRT) +/-concomitant systemic therapy. The most 'unfavourable' subgroup was characterized by total GTV (tGTV) of > 70 cc, translating in ~50 and 65% 3-year disease free (DFS) and overall survival (OAS, vs 68% and 88% in tGTV < 70 cc, p = 0.001 and 0.0001), and ~25% distant spread (vs 6% for tGTV < 70 cc, p < 0.0001).The aim of this report was to analyze whether there is a subgroup out of patients with tGTV > 70 cc, which only marginally benefits from intensive curative treatment.