Impact of tumor volume and systemic therapy on outcome in patients undergoing IMRT for large volume head neck cancer.

Publication

Impact of tumor volume and systemic therapy on outcome in patients undergoing IMRT for large volume head neck cancer.

Journal Paper/Review - Sep 22, 2011

Studer Gabriela, Rordorf Tamara, Glanzmann Christoph

Citation

Studer G, Rordorf T, Glanzmann C. Impact of tumor volume and systemic therapy on outcome in patients undergoing IMRT for large volume head neck cancer. Radiat Oncol 2011; 6:120.

Type

Journal Paper/Review (English)

Journal

Radiat Oncol 2011; 6

Publication Date

Sep 22, 2011

Issn Electronic

1748-717X

Pages

120

Brief description/objective

Former prospective analyses revealed gross tumor volume (GTV) as the most reliable parameter to statistically significantly predict disease control in head neck cancer (HNC) patients treated with definitive intensity modulated radiation therapy (IMRT) +/-concomitant systemic therapy. The most 'unfavourable' subgroup was characterized by total GTV (tGTV) of > 70 cc, translating in ~50 and 65% 3-year disease free (DFS) and overall survival (OAS, vs 68% and 88% in tGTV < 70 cc, p = 0.001 and 0.0001), and ~25% distant spread (vs 6% for tGTV < 70 cc, p < 0.0001).The aim of this report was to analyze whether there is a subgroup out of patients with tGTV > 70 cc, which only marginally benefits from intensive curative treatment.