Transfer of antiretroviral drugs into breastmilk: a prospective study from the Swiss Mother and Child HIV Cohort Study.

Publikation

Transfer of antiretroviral drugs into breastmilk: a prospective study from the Swiss Mother and Child HIV Cohort Study.

Wissenschaftlicher Artikel/Review - 28.11.2022

Aebi-Popp Karoline, Kahlert Christian, Crisinel Pierre-Alex, Decosterd Laurent, Saldanha Susana Alves, Hoesli Irene, Martinez de Tejada Begoña, Duppenthaler Andrea, Rauch Andri, Marzolini Catia

Zitation

Aebi-Popp K, Kahlert C, Crisinel P, Decosterd L, Saldanha S, Hoesli I, Martinez de Tejada B, Duppenthaler A, Rauch A, Marzolini C. Transfer of antiretroviral drugs into breastmilk: a prospective study from the Swiss Mother and Child HIV Cohort Study. J Antimicrob Chemother 2022; 77:3436-3442.

Art

Wissenschaftlicher Artikel/Review (Englisch)

Zeitschrift

J Antimicrob Chemother 2022; 77

Veröffentlichungsdatum

28.11.2022

eISSN (Online)

1460-2091

Seiten

3436-3442

Kurzbeschreibung/Zielsetzung

In 2018, Switzerland changed its guidelines to support women living with HIV wishing to breastfeed. The exposure of antiretroviral drugs (ARVs) in breastmilk and the ingested daily dose by the breastfed infant are understudied, notably for newer ARVs. This study aimed to quantify ARV concentrations in maternal plasma and breastmilk to determine the milk/plasma ratio, to estimate daily infant ARV dose from breastfeeding and to measure ARV concentrations in infants.