Transfer of antiretroviral drugs into breastmilk: a prospective study from the Swiss Mother and Child HIV Cohort Study.

Publication

Transfer of antiretroviral drugs into breastmilk: a prospective study from the Swiss Mother and Child HIV Cohort Study.

Journal Paper/Review - Nov 28, 2022

Aebi-Popp Karoline, Kahlert Christian, Crisinel Pierre-Alex, Decosterd Laurent, Saldanha Susana Alves, Hoesli Irene, Martinez de Tejada Begoña, Duppenthaler Andrea, Rauch Andri, Marzolini Catia

Citation

Aebi-Popp K, Kahlert C, Crisinel P, Decosterd L, Saldanha S, Hoesli I, Martinez de Tejada B, Duppenthaler A, Rauch A, Marzolini C. Transfer of antiretroviral drugs into breastmilk: a prospective study from the Swiss Mother and Child HIV Cohort Study. J Antimicrob Chemother 2022; 77:3436-3442.

Type

Journal Paper/Review (English)

Journal

J Antimicrob Chemother 2022; 77

Publication Date

Nov 28, 2022

Issn Electronic

1460-2091

Pages

3436-3442

Brief description/objective

In 2018, Switzerland changed its guidelines to support women living with HIV wishing to breastfeed. The exposure of antiretroviral drugs (ARVs) in breastmilk and the ingested daily dose by the breastfed infant are understudied, notably for newer ARVs. This study aimed to quantify ARV concentrations in maternal plasma and breastmilk to determine the milk/plasma ratio, to estimate daily infant ARV dose from breastfeeding and to measure ARV concentrations in infants.