Parameters of the Lyman Model for Calculation of Normal-Tissue Complication Probability: A Systematic Literature Review.

Publikation

Parameters of the Lyman Model for Calculation of Normal-Tissue Complication Probability: A Systematic Literature Review.

Wissenschaftlicher Artikel/Review - 24.08.2022

Dennstädt Fabio, Medová Michaela, Putora Paul Martin, Glatzer Markus

Zitation

Dennstädt F, Medová M, Putora P, Glatzer M. Parameters of the Lyman Model for Calculation of Normal-Tissue Complication Probability: A Systematic Literature Review. Int J Radiat Oncol Biol Phys 2022; 115:696-706.

Art

Wissenschaftlicher Artikel/Review (Englisch)

Zeitschrift

Int J Radiat Oncol Biol Phys 2022; 115

Veröffentlichungsdatum

24.08.2022

eISSN (Online)

1879-355X

Seiten

696-706

Kurzbeschreibung/Zielsetzung

The Lyman model is one of the most used radiobiological models for calculation of normal-tissue complication probability (NTCP). Since its introduction in 1985, many authors have published parameter values for the model based on clinical data of different radiotherapeutic situations. This study attempted to collect the entirety of radiobiological parameter sets published to date and provide an overview of the data basis for different variations of the model. Furthermore, it sought to compare the parameter values and calculated NTCPs for selected endpoints with sufficient data available.