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GRAALL-2014 follows the GRAALL-2003 and 2005 trials.
The GRAALL-2014 trial is subdivided in three sub-studies: GRAALL-2014/B, GRAALL-2014/T and GRAAPH-2014respectively for patients with B-lineage Ph-negative ALL, T-lineage ALL or Ph+ ALL.
France, Switzerland and Belgium will participate to GRAALL-2014.
The general objective of GRAALL-2014 is to improve the results of our pediatric-inspired approach. For this purpose, we will consider the characteristics of ALL (using the new risk classification system) as well as age-related toxicities in order to improve tolerance.