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Systemic lupus erythematosus (SLE) is a chronic multisystem autoimmune disease. So far, there is little evidence for the existence of specific biologic markers reliably indicating clinical activity and a rather wide panel of unspecific markers indicating systemic and/or organ manifestation is used.
In this bicentre prospective observational cohort study, our aim is to evaluate the associations between established bio-/activation markers4 as anti-ds DNA ab and complement factors with exact determination of consumption (C1q, C3, C4, CH50) and activation (C3a, iC3b, C3d, C4d, C5a, C5b-9) and according to recent findings, factors directly linked to the pathogenesis of SLE, i.e. HMGB, INFα, NET degradation, free light chains (FLC)). We want to correlate them with clinical disease activity and damage and compare them with sex and aged matched healthy controls.