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Background:
Interferon-γ Release assays (IGRA) have partly replaced conventional tuberculin skin tests (TST) in the recent years due to their higher specificity and standardised test procedures including a positive / negative control. Nevertheless it is currently unknown if IGRA reverse to negative results and in what time after successful TB-treatment in HIV-infected persons.

Study Aims:
The aim of the study is to evaluate the rate of positive / negative / indeterminate IGRA test results and absolute Mycobacterium tuberculosis-specific cytokine / chemokine secretion (IGRA-specific and purified protein derivate (PPD) –specific) titres in association with the time since successful tuberculosis (TB) -treatment as an indicator of the IGRA reversion rate over time, taking into account possible confounders, in particular CD4 recovery rate and TB re-exposure risk.

Study Design:
Cohort study analysing the effect of time since TB-treatment on IGRA / PPD negativity rates in all HIV-infected patients enrolled in the SHCS with previous treatment for active TB.