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Two poyclonal depleting antibody products as an immunosuppresive induction therapy will be compared regarding safety profile and efficacy in immunological high risk patients after renal transplantion.

1. a regimen consisting of a triple drug therapy with Tacrolimus, MMF, and steroids as basis therapy plus IVIG for 5 days (total dose 2g/kg bw. max. 140g). in addition, the patients receive intra-operative 9 mg/kg bw.ATG-Fresenius S (completed before reperfusion), followed by 3 mg/kg bw/d for the next 4 consecutive days.

2. a regimen consisting of a triple drug therapy with Tacrolimus, MMF, and steroids as basis therapy plus IVIG for 5 days (total dose 2g/kg bw. max. 140g). in addition, the patients receive intra-operative 1.5 mg/kg bw Thymoglobulin (completed before reperfusion), followed by 1.5mg/kg bw/d for the next 3 consecutive days.