Assessment of Torque Teno Virus (TTV) viral load as marker for baseline immunity in healthcare workers

Projekt

Assessment of Torque Teno Virus (TTV) viral load as marker for baseline immunity in healthcare workers

Geplant · 2024 bis 2025

Kohler Philipp, Kuster Stefan, Kahlert Christian, Grässli Fabian

Art

Klinische Forschung

Reichweite

Multizentrisch, KSSG als Hauptzentrum

Bereiche

Infektiologie | Infektionsprävention | Reisemedizin

Status

Geplant

Start

2024

Ende

2025

Finanzierungsart

Fördermittel KSSG

Studiendesign

Cohort study

Schlagwörter (Tags)

SARS-CoV-2 vaccination, healthcare workers, functional immunity

Webseite

https://surprise.infekt-kssg.ch/

Projektpartner

Laurent Kaiser, University Hospital Geneva

Weitere Informationen

In a small pilot study of serological samples in our cohort, we found an association of number of SARS-CoV-2 vaccinations received with and increase in TTV viral load. As observational data from the same cohort showed the number of SARS-CoV-2 vaccinations to be strongly associated with influenza-like illnesses (ILI) and workday loss, we hypothesize, that TTV viral loads may differ according to vaccination status and may also show a correlation with ILI episodes and may thus be used as marker for functional immunity in this population.

Kurzbeschreibung/Zielsetzung

This project will retrospectively assess the association of SARS-CoV-2 vaccination status with TTV viral loads in a cohort of healthcare workers and correlation with susceptibility to respiratory infections, determined by total number of influenza-like illness episodes during the winter period 2023/2024.

The results will help to determine the value of TTV viral load as marker of functional immunity in this population and guide further prospective evaluations.