Assessment of Torque Teno Virus (TTV) viral load as marker for baseline immunity in healthcare workers

Project

Assessment of Torque Teno Virus (TTV) viral load as marker for baseline immunity in healthcare workers

Scheduled · 2024 until 2025

Kohler Philipp, Kuster Stefan, Kahlert Christian, Grässli Fabian

Type

Clinical Studies

Range

Multicentric, KSSG as main centre

Units

Division of Infectious Diseases, Infection Prevention and Travel Medicine

Status

Scheduled

Start Date

2024

End Date

2025

Financing

KSSG

Study Design

Cohort study

Keywords

SARS-CoV-2 vaccination, healthcare workers, functional immunity

Homepage

https://surprise.infekt-kssg.ch/

Partner

Laurent Kaiser, University Hospital Geneva

Additional Information

In a small pilot study of serological samples in our cohort, we found an association of number of SARS-CoV-2 vaccinations received with and increase in TTV viral load. As observational data from the same cohort showed the number of SARS-CoV-2 vaccinations to be strongly associated with influenza-like illnesses (ILI) and workday loss, we hypothesize, that TTV viral loads may differ according to vaccination status and may also show a correlation with ILI episodes and may thus be used as marker for functional immunity in this population.

Brief description/objective

This project will retrospectively assess the association of SARS-CoV-2 vaccination status with TTV viral loads in a cohort of healthcare workers and correlation with susceptibility to respiratory infections, determined by total number of influenza-like illness episodes during the winter period 2023/2024.

The results will help to determine the value of TTV viral load as marker of functional immunity in this population and guide further prospective evaluations.