Prof. Dr. Markus Weber
Klinik-/Instituts-/Zentrumsleiter/in
Muskelzentrum | ALS Clinic · Dept. III
MUNIX in children with spinal muscular atrophy: An unexpected journey
Neuwirth C, Weber M. MUNIX in children with spinal muscular atrophy: An unexpected journey. Muscle Nerve 2020; 62:565-566.
11.09.2020MUNIX in children with spinal muscular atrophy: An unexpected journey
11.09.2020Muscle Nerve 2020; 62:565-566
Neuwirth Christoph, Weber Markus
Identification and Preclinical Development of a 2,5,6-Trisubstituted Fluorinated Pyridine Derivative as a Radioligand for the Positron Emission Tomography Imaging of Cannabinoid Type 2 Receptors
Haider A, Pacher P, Herde A, Spinelli F, Ahmed H, Atz K, Keller C, Weber M, Schibli R, Mu L, Grether U, Knuesel I, Bartelmus C, Gobbi L, Kretz J, Ullmer C, Brink A, Honer M, Woltering T, Muri D, Iding H, Bürkler M, Binder M, Ametamey S. Identification and Preclinical Development of a 2,5,6-Trisubstituted Fluorinated Pyridine Derivative as a Radioligand for the Positron Emission Tomography Imaging of Cannabinoid Type 2 Receptors. J Med Chem 2020; 63:10287-10306.
01.09.2020Identification and Preclinical Development of a 2,5,6-Trisubstituted Fluorinated Pyridine Derivative as a Radioligand for the Positron Emission Tomography Imaging of Cannabinoid Type 2 Receptors
01.09.2020J Med Chem 2020; 63:10287-10306
Haider Ahmed, Pacher Pal, Herde Adrienne Müller, Spinelli Francesco, Ahmed Hazem, Atz Kenneth, Keller Claudia, Weber Markus, Schibli Roger, Mu Linjing, Grether Uwe, Knuesel Irene, Bartelmus Christian, Gobbi Luca, Kretz Julian, Ullmer Christoph, Brink Andreas, Honer Michael, Woltering Thomas J, Muri Dieter, Iding Hans, Bürkler Markus, Binder Martin, Ametamey Simon M
TRICALS: creating a highway toward a cure
van Eijk R, Hardiman O, Al-Chalabi A, van Es M, Reviers E, Povedano M, Corcia P, Ingre C, Weber M, Chio A, Van Damme P, Roes K, McDermott C, Kliest T, van den Berg L. TRICALS: creating a highway toward a cure. Amyotroph Lateral Scler Frontotemporal Degener 2020; 21:496-501.
09.07.2020TRICALS: creating a highway toward a cure
09.07.2020Amyotroph Lateral Scler Frontotemporal Degener 2020; 21:496-501
van Eijk Ruben P A, Hardiman Orla, Al-Chalabi Ammar, van Es Michael A, Reviers Evy, Povedano Monica, Corcia Philippe, Ingre Caroline, Weber Markus, Chio Adriano, Van Damme Philip, Roes Kit C B, McDermott Christopher J, Kliest Tessa, van den Berg Leonard H
Estimating the Number of Motor Neurons: First Go to the Roots Before Cropping the Fruits
Neuwirth C, Weber M. Estimating the Number of Motor Neurons: First Go to the Roots Before Cropping the Fruits. Muscle Nerve 2020; 62:154-155.
29.05.2020Estimating the Number of Motor Neurons: First Go to the Roots Before Cropping the Fruits
29.05.2020Muscle Nerve 2020; 62:154-155
Neuwirth Christoph, Weber Markus
Nine Hole Peg Test and Transcranial Magnetic Stimulation: Useful to Evaluate Dexterity of the Hand and Disease Progression in Amyotrophic Lateral Sclerosis
Czell D, Neuwirth C, Weber M, Sartoretti-Schefer S, Gutzeit A, Reischauer C. Nine Hole Peg Test and Transcranial Magnetic Stimulation: Useful to Evaluate Dexterity of the Hand and Disease Progression in Amyotrophic Lateral Sclerosis. Neurol Res Int 2019; 2019:7397491.
07.11.2019Nine Hole Peg Test and Transcranial Magnetic Stimulation: Useful to Evaluate Dexterity of the Hand and Disease Progression in Amyotrophic Lateral Sclerosis
07.11.2019Neurol Res Int 2019; 2019:7397491
Czell David, Neuwirth Christoph, Weber Markus, Sartoretti-Schefer Sabine, Gutzeit Andreas, Reischauer Carolin
Poly-glycine-alanine exacerbates C9orf72 repeat expansion-mediated DNA damage via sequestration of phosphorylated ATM and loss of nuclear hnRNPA3
Nihei Y, Edbauer D, Nuscher B, Kamp F, Bavarian Brain Banking Alliance, German Consortium for Frontotemporal Lobar Degeneration, Weber M, Sommacal A, Hermann A, Japtok J, Khosravi B, Zhou Q, Arzberger T, Werner G, Mori K, Haass C. Poly-glycine-alanine exacerbates C9orf72 repeat expansion-mediated DNA damage via sequestration of phosphorylated ATM and loss of nuclear hnRNPA3. Acta Neuropathol 2019; 139:99-118.
23.10.2019Poly-glycine-alanine exacerbates C9orf72 repeat expansion-mediated DNA damage via sequestration of phosphorylated ATM and loss of nuclear hnRNPA3
23.10.2019Acta Neuropathol 2019; 139:99-118
Nihei Yoshihiro, Edbauer Dieter, Nuscher Brigitte, Kamp Frits, Bavarian Brain Banking Alliance, German Consortium for Frontotemporal Lobar Degeneration, Weber Markus, Sommacal Andreas, Hermann Andreas, Japtok Julia, Khosravi Barham, Zhou Qihui, Arzberger Thomas, Werner Georg, Mori Kohji, Haass Christian
The revised El Escorial criteria "clinically probable laboratory supported ALS"-once a promising now a superfluous category?
Braun N, Macklin E, Sinani E, Sherman A, Weber M, Pooled Resource Open-Access ALS Clinical Trials Consortium. The revised El Escorial criteria "clinically probable laboratory supported ALS"-once a promising now a superfluous category?. Amyotroph Lateral Scler Frontotemporal Degener 2019; 21:24-28.
27.09.2019The revised El Escorial criteria "clinically probable laboratory supported ALS"-once a promising now a superfluous category?
27.09.2019Amyotroph Lateral Scler Frontotemporal Degener 2019; 21:24-28
Braun Nathalie, Macklin Eric A, Sinani Ervin, Sherman Alexander, Weber Markus, Pooled Resource Open-Access ALS Clinical Trials Consortium
Misfolded SOD1 inclusions in patients with mutations in and other ALS/FTD-associated genes
Forsberg K, Graffmo K, Pakkenberg B, Weber M, Nielsen M, Marklund S, Brännström T, Andersen P. Misfolded SOD1 inclusions in patients with mutations in and other ALS/FTD-associated genes. J Neurol Neurosurg Psychiatry 2019; 90:861-869.
16.04.2019Misfolded SOD1 inclusions in patients with mutations in and other ALS/FTD-associated genes
16.04.2019J Neurol Neurosurg Psychiatry 2019; 90:861-869
Forsberg Karin, Graffmo Karin, Pakkenberg Bente, Weber Markus, Nielsen Martin, Marklund Stefan, Brännström Thomas, Andersen Peter Munch
ROCK-ALS: Protocol for a Randomized, Placebo-Controlled, Double-Blind Phase IIa Trial of Safety, Tolerability and Efficacy of the Rho Kinase (ROCK) Inhibitor Fasudil in Amyotrophic Lateral Sclerosis
Lingor P, Koch J, Ludolph A, Frontini R, Blankenstein C, Bidner H, Kuzma-Kozakiewicz M, Benatar M, Günther R, Neuwirth C, Leha A, Hilgers R, Friede T, Camu W, Weber M, ROCK-ALS Investigators. ROCK-ALS: Protocol for a Randomized, Placebo-Controlled, Double-Blind Phase IIa Trial of Safety, Tolerability and Efficacy of the Rho Kinase (ROCK) Inhibitor Fasudil in Amyotrophic Lateral Sclerosis. Front Neurol 2019; 10:293.
27.03.2019ROCK-ALS: Protocol for a Randomized, Placebo-Controlled, Double-Blind Phase IIa Trial of Safety, Tolerability and Efficacy of the Rho Kinase (ROCK) Inhibitor Fasudil in Amyotrophic Lateral Sclerosis
27.03.2019Front Neurol 2019; 10:293
Lingor Paul, Koch Jan C, Ludolph Albert, Frontini Roberto, Blankenstein Christiane, Bidner Helen, Kuzma-Kozakiewicz Magdalena, Benatar Michael, Günther René, Neuwirth Christoph, Leha Andreas, Hilgers Reinhard, Friede Tim, Camu William, Weber Markus, ROCK-ALS Investigators
Revised Airlie House consensus guidelines for design and implementation of ALS clinical trials
van den Berg L, McDermott C, Pioro E, Rosenfeld J, Silani V, Turner M, Weber M, Brooks B, Miller R, Mitsumoto H, Lomen-Hoerth C, Gubitz A, Genge A, Sorenson E, Gronseth G, Macklin E, Andrews J, Baloh R, Benatar M, Berry J, Chio A, Corcia P, Airlie House ALS Clinical Trials Guidelines Group. Revised Airlie House consensus guidelines for design and implementation of ALS clinical trials. Neurology 2019; 92:e1610-e1623.
08.03.2019Revised Airlie House consensus guidelines for design and implementation of ALS clinical trials
08.03.2019Neurology 2019; 92:e1610-e1623
van den Berg Leonard H, McDermott Christopher J, Pioro Erik P, Rosenfeld Jeffrey, Silani Vincenzo, Turner Martin R, Weber Markus, Brooks Benjamin Rix, Miller Robert G, Mitsumoto Hiroshi, Lomen-Hoerth Catherine, Gubitz Amelie K, Genge Angela, Sorenson Eric, Gronseth Gary, Macklin Eric A, Andrews Jinsy, Baloh Robert H, Benatar Michael, Berry James D, Chio Adriano, Corcia Philippe, Airlie House ALS Clinical Trials Guidelines Group
Assessment of the reliability of the motor unit size index (MUSIX) in single subject "round-robin" and multi-centre settings
Alix J, Nandedkar S, Stålberg E, Barkhaus P, Furtula J, van Dijk J, Baldinger R, Costa J, Otto M, Sandberg A, Schrooten M, Omer T, Moglia C, Neuwirth C, Gelder L, Burkhardt C, Castro J, de Carvalho M, Gawel M, Goedee S, Grosskreutz J, Lenglet T, Weber M. Assessment of the reliability of the motor unit size index (MUSIX) in single subject "round-robin" and multi-centre settings. Clin Neurophysiol 2019; 130:666-674.
21.02.2019Assessment of the reliability of the motor unit size index (MUSIX) in single subject "round-robin" and multi-centre settings
21.02.2019Clin Neurophysiol 2019; 130:666-674
Alix James J P, Nandedkar Sanjeev, Stålberg Erik, Barkhaus Paul E, Furtula Jasna, van Dijk Johannes P, Baldinger Reto, Costa João, Otto Marit, Sandberg Arne, Schrooten Maarten, Omer Taha, Moglia Cristina, Neuwirth Christoph, Gelder Lucy, Burkhardt Christian, Castro José, de Carvalho Mamede, Gawel Malgorzata, Goedee Stephan, Grosskreutz Julian, Lenglet Timothée, Weber Markus
Reply: Adult-onset distal spinal muscular atrophy: a new phenotype associated with KIF5A mutations
German ALS network MND-NET, Weis J, Dorst J, Volk A, Borck G, Sperfeld A, de Carvalho M, Klopstock T, Sendtner M, Otto M, Schuster J, Weishaupt J, Andersen P, Ludolph A, Meitinger T, Freischmidt A, Danzer K, Braak H, Del Tredici K, Jablonka S, Kubisch C, Zeller D, Weydt P, Grosskreutz J, Meyer T, Petri S, Grehl T, Müller K, Yilmaz R, Rosenbohm A, Ruf W, Neuwirth C, Hübers A, Günther K, Knehr A, Jordan B, Schrank B, Claeys K, Pinto S, Weber M, Brenner D. Reply: Adult-onset distal spinal muscular atrophy: a new phenotype associated with KIF5A mutations. Brain 2019; 142:e67.
01.01.2019Reply: Adult-onset distal spinal muscular atrophy: a new phenotype associated with KIF5A mutations
01.01.2019Brain 2019; 142:e67
German ALS network MND-NET, Weis Joachim, Dorst Johannes, Volk Alexander E, Borck Guntram, Sperfeld Anne, de Carvalho Mamede, Klopstock Thomas, Sendtner Michael, Otto Markus, Schuster Joachim, Weishaupt Jochen H, Andersen Peter M, Ludolph Albert C, Meitinger Thomas, Freischmidt Axel, Danzer Karin M, Braak Heiko, Del Tredici Kelly, Jablonka Sibylle, Kubisch Christian, Zeller Daniel, Weydt Patrick, Grosskreutz Julian, Meyer Thomas, Petri Susanne, Grehl Torsten, Müller Kathrin, Yilmaz Rüstem, Rosenbohm Angela, Ruf Wolfgang, Neuwirth Christoph, Hübers Annemarie, Günther Kornelia, Knehr Antje, Jordan Berit, Schrank Berthold, Claeys Kristl G, Pinto Susana, Weber Markus, Brenner David
Diagnostic criteria for amyotrophic lateral sclerosis: A multicentre study of inter-rater variation and sensitivity
Johnsen B, Swash M, Abraham A, Drory V, Weber M, Neuwirth C, Czell D, Maderna L, Schofield I, Liguori R, Nix W, Camdessanché J, Dengler R, Paracka L, Kollewe K, Fuglsang-Frederiksen A, Pugdahl K, DE CARVALHO M. Diagnostic criteria for amyotrophic lateral sclerosis: A multicentre study of inter-rater variation and sensitivity. Clin Neurophysiol 2018
09.12.2018Diagnostic criteria for amyotrophic lateral sclerosis: A multicentre study of inter-rater variation and sensitivity
09.12.2018Clin Neurophysiol 2018
Johnsen B, Swash M, Abraham A, Drory V E, Weber Markus, Neuwirth Christoph, Czell D, Maderna L, Schofield I, Liguori R, Nix W, Camdessanché J P, Dengler R, Paracka L, Kollewe K, Fuglsang-Frederiksen A, Pugdahl K, DE CARVALHO M
A human-derived antibody targets misfolded SOD1 and ameliorates motor symptoms in mouse models of amyotrophic lateral sclerosis
Maier M, Nitsch R, Christoph H, Weber M, Perrin S, Stehle T, Späni C, Kulic L, Vieira F, McAfoose J, Preisig D, Montrasio F, Wirth F, Welt T, Grimm J. A human-derived antibody targets misfolded SOD1 and ameliorates motor symptoms in mouse models of amyotrophic lateral sclerosis. Sci Transl Med 2018; 10
05.12.2018A human-derived antibody targets misfolded SOD1 and ameliorates motor symptoms in mouse models of amyotrophic lateral sclerosis
05.12.2018Sci Transl Med 2018; 10
Maier Marcel, Nitsch Roger M, Christoph Hock, Weber Markus, Perrin Steve, Stehle Thilo, Späni Claudia, Kulic Luka, Vieira Fernando G, McAfoose Jordan, Preisig Daniel, Montrasio Fabio, Wirth Fabian, Welt Tobias, Grimm Jan
Motor Unit Number Index (MUNIX) of hand muscles is a disease biomarker for adult spinal muscular atrophy
Günther R, Neuwirth C, Koch J, Lingor P, Braun N, Untucht R, Petzold D, Weber M, Hermann A. Motor Unit Number Index (MUNIX) of hand muscles is a disease biomarker for adult spinal muscular atrophy. Clin Neurophysiol 2018
24.11.2018Motor Unit Number Index (MUNIX) of hand muscles is a disease biomarker for adult spinal muscular atrophy
24.11.2018Clin Neurophysiol 2018
Günther René, Neuwirth Christoph, Koch Jan Christoph, Lingor Paul, Braun Nathalie, Untucht Robert, Petzold Daniel, Weber Markus, Hermann Andreas
Metabotropic glutamate receptor subtype 5 is altered in LPS-induced murine neuroinflammation model and in the brains of AD and ALS patients
Müller Herde A, Schibli R, Weber M, Ametamey S. Metabotropic glutamate receptor subtype 5 is altered in LPS-induced murine neuroinflammation model and in the brains of AD and ALS patients. Eur J Nucl Med Mol Imaging 2018
05.10.2018Metabotropic glutamate receptor subtype 5 is altered in LPS-induced murine neuroinflammation model and in the brains of AD and ALS patients
05.10.2018Eur J Nucl Med Mol Imaging 2018
Müller Herde Adrienne, Schibli Roger, Weber Markus, Ametamey Simon M
In-vivo evaluation of neuronal and glial changes in amyotrophic lateral sclerosis with diffusion tensor spectroscopy
Reischauer C, Gutzeit A, Neuwirth C, Fuchs A, Sartoretti-Schefer S, Weber M, Czell D. In-vivo evaluation of neuronal and glial changes in amyotrophic lateral sclerosis with diffusion tensor spectroscopy. Neuroimage Clin 2018; 20:993-1000.
03.10.2018In-vivo evaluation of neuronal and glial changes in amyotrophic lateral sclerosis with diffusion tensor spectroscopy
03.10.2018Neuroimage Clin 2018; 20:993-1000
Reischauer Carolin, Gutzeit Andreas, Neuwirth Christoph, Fuchs Alexander, Sartoretti-Schefer Sabine, Weber Markus, Czell David
Amyotrophe Lateralsklerose - eine Krankheit mit besonderen Herausforderungen
Braun N, Neuwirth C, Weber M. Amyotrophe Lateralsklerose - eine Krankheit mit besonderen Herausforderungen. palliative ch 2018
30.07.2018Amyotrophe Lateralsklerose - eine Krankheit mit besonderen Herausforderungen
30.07.2018palliative ch 2018
Braun Nathalie, Neuwirth Christoph, Weber Markus
Implementing Motor Unit Number Index (MUNIX) in a large clinical trial: Real world experience from 27 centres
Neuwirth C, Finegan E, Glass J, Babu S, Ladha S, Kwast-Rabben O, Juntas-Morales R, Coffey A, Chaudhry V, Vu T, Saephanh C, Newhard C, Zakrzewski M, Rosier E, Hamel N, Raheja D, Raaijman J, Ferguson T, Tümmler A, Appelfeller M, Braun N, Claeys K, Bucelli R, Fournier C, Bromberg M, Petri S, Goedee S, Lenglet T, Leppanen R, Canosa A, Goodman I, Al-Lozi M, Ohkubo T, Hübers A, Atassi N, Abrahao A, Funke A, Weber M. Implementing Motor Unit Number Index (MUNIX) in a large clinical trial: Real world experience from 27 centres. Clin Neurophysiol 2018; 129:1756-1762.
03.05.2018Implementing Motor Unit Number Index (MUNIX) in a large clinical trial: Real world experience from 27 centres
03.05.2018Clin Neurophysiol 2018; 129:1756-1762
Neuwirth Christoph, Finegan Eoin, Glass Jonathan D, Babu Suma, Ladha Shafeeq S, Kwast-Rabben Olga, Juntas-Morales Raul, Coffey Amina, Chaudhry Vinay, Vu Tuan, Saephanh Chow, Newhard Colleen, Zakrzewski Marion, Rosier Esther, Hamel Nancy, Raheja Divisha, Raaijman Jesper, Ferguson Toby, Tümmler Anke, Appelfeller Martin, Braun Nathalie, Claeys Kristl G, Bucelli Robert, Fournier Christina, Bromberg Mark, Petri Susanne, Goedee Stephan, Lenglet Timothée, Leppanen Ron, Canosa Antonio, Goodman Ira, Al-Lozi Muhammad, Ohkubo Takuya, Hübers Annemarie, Atassi Nazem, Abrahao Agessandro, Funke Andreas, Weber Markus
Prognosis for patients with amyotrophic lateral sclerosis: development and validation of a personalised prediction model
van den Berg L, Grosskreutz J, Weber M, Couratier P, Corcia P, van Es M, Bredenoord A, Shaw C, Gunkel A, Rödiger A, Ludolph A, Petri S, de Carvalho M, Veldink J, Moons K, Hardiman O, Chio A, Al-Chalabi A, Shaw P, Turner M, Talbot K, Van Damme P, Ringer T, Körner S, Gromicho M, Pinto S, Thompson A, McDermott C, Martin S, Calvo A, Rooney J, van Eijk R, Visser A, Debray T, Kobeleva X, Rosenbohm A, Stubendorff B, Hollinger H, Kazoka M, Heverin M, Vajda A, van Rheenen W, Van Vugt J, Dekker A, Middelkoop B, Sommer H, Westeneng H. Prognosis for patients with amyotrophic lateral sclerosis: development and validation of a personalised prediction model. Lancet Neurol 2018; 17:423-433.
26.03.2018Prognosis for patients with amyotrophic lateral sclerosis: development and validation of a personalised prediction model
26.03.2018Lancet Neurol 2018; 17:423-433
van den Berg Leonard H, Grosskreutz Julian, Weber Markus, Couratier Philippe, Corcia Philippe, van Es Michael A, Bredenoord Annelien L, Shaw Christopher E, Gunkel Anne, Rödiger Annekathrin, Ludolph Albert C, Petri Susanne, de Carvalho Mamede, Veldink Jan H, Moons Karel G M, Hardiman Orla, Chio Adriano, Al-Chalabi Ammar, Shaw Pamela J, Turner Martin R, Talbot Kevin, Van Damme Philip, Ringer Thomas M, Körner Sonja, Gromicho Marta, Pinto Susana, Thompson Alexander G, McDermott Christopher J, Martin Sarah, Calvo Andrea, Rooney James P K, van Eijk Ruben P A, Visser Anne E, Debray Thomas P A, Kobeleva Xenia, Rosenbohm Angela, Stubendorff Beatrice, Hollinger Hannah, Kazoka Mbombe, Heverin Mark, Vajda Alice, van Rheenen Wouter, Van Vugt Joke J F A, Dekker Annelot M, Middelkoop Bas M, Sommer Helma, Westeneng Henk-Jan