Peter Lohse
Development of a uniform, very aggressive disease phenotype in all homozygous carriers of the NOD2 mutation p.Leu1007fsX1008 with Crohn's disease and active smoking status resulting in ileal stenosis requiring surgery.
Schnitzler F, Friedrich M, Angelberger M, Diegelmann J, Stallhofer J, Wolf C, Dütschler J, Truniger S, Olszak T, Beigel F, Tillack C, Lohse P, Brand S. Development of a uniform, very aggressive disease phenotype in all homozygous carriers of the NOD2 mutation p.Leu1007fsX1008 with Crohn's disease and active smoking status resulting in ileal stenosis requiring surgery. PloS one 2020; 15:e0236421.
27.07.2020Development of a uniform, very aggressive disease phenotype in all homozygous carriers of the NOD2 mutation p.Leu1007fsX1008 with Crohn's disease and active smoking status resulting in ileal stenosis requiring surgery.
27.07.2020PloS one 2020; 15:e0236421
Schnitzler Fabian, Friedrich Matthias, Angelberger Marianne, Diegelmann Julia, Stallhofer Johannes, Wolf Christiane, Dütschler Joel, Truniger Samuel, Olszak Torsten, Beigel Florian, Tillack Cornelia, Lohse Peter, Brand Stephan
Lipocalin-2 Is a Disease Activity Marker in Inflammatory Bowel Disease Regulated by IL-17A, IL-22, and TNF-α and Modulated by IL23R Genotype Status
Stallhofer J, Beigel F, Schnitzler F, Tillack-Schreiber C, Glas J, Lohse P, Wetzke M, Konrad-Zerna A, Friedrich M, Brand S. Lipocalin-2 Is a Disease Activity Marker in Inflammatory Bowel Disease Regulated by IL-17A, IL-22, and TNF-α and Modulated by IL23R Genotype Status. Inflamm Bowel Dis 2015; 21:2327-40.
01.10.2015Lipocalin-2 Is a Disease Activity Marker in Inflammatory Bowel Disease Regulated by IL-17A, IL-22, and TNF-α and Modulated by IL23R Genotype Status
01.10.2015Inflamm Bowel Dis 2015; 21:2327-40
Stallhofer Johannes, Beigel Florian, Schnitzler Fabian, Tillack-Schreiber Cornelia, Glas Jürgen, Lohse Peter, Wetzke Martin, Konrad-Zerna Astrid, Friedrich Matthias, Brand Stephan
The NOD2 Single Nucleotide Polymorphism rs72796353 (IVS4+10 A>C) Is a Predictor for Perianal Fistulas in Patients with Crohn's Disease in the Absence of Other NOD2 Mutations
Schnitzler F, Lohse P, Glas J, Göke B, Beigel F, Tillack C, Olszak T, Diegelmann J, Angelberger M, Stallhofer J, Wolf C, Friedrich M, Brand S. The NOD2 Single Nucleotide Polymorphism rs72796353 (IVS4+10 A>C) Is a Predictor for Perianal Fistulas in Patients with Crohn's Disease in the Absence of Other NOD2 Mutations. PloS one 2015; 10:e0116044.
06.07.2015The NOD2 Single Nucleotide Polymorphism rs72796353 (IVS4+10 A>C) Is a Predictor for Perianal Fistulas in Patients with Crohn's Disease in the Absence of Other NOD2 Mutations
06.07.2015PloS one 2015; 10:e0116044
Schnitzler Fabian, Lohse Peter, Glas Jürgen, Göke Burkhard, Beigel Florian, Tillack Cornelia, Olszak Torsten, Diegelmann Julia, Angelberger Marianne, Stallhofer Johannes, Wolf Christiane, Friedrich Matthias, Brand Stephan
The NOD2 p.Leu1007fsX1008 mutation (rs2066847) is a stronger predictor of the clinical course of Crohn's disease than the FOXO3A intron variant rs12212067
Schnitzler F, Lohse P, Glas J, Göke B, Stallhofer J, Tillack C, Beigel F, Olszak T, Diegelmann J, Angelberger M, Wolf C, Friedrich M, Brand S. The NOD2 p.Leu1007fsX1008 mutation (rs2066847) is a stronger predictor of the clinical course of Crohn's disease than the FOXO3A intron variant rs12212067. PloS one 2014; 9:e108503.
03.11.2014The NOD2 p.Leu1007fsX1008 mutation (rs2066847) is a stronger predictor of the clinical course of Crohn's disease than the FOXO3A intron variant rs12212067
03.11.2014PloS one 2014; 9:e108503
Schnitzler Fabian, Lohse Peter, Glas Jürgen, Göke Burkhard, Stallhofer Johannes, Tillack Cornelia, Beigel Florian, Olszak Torsten, Diegelmann Julia, Angelberger Marianne, Wolf Christiane, Friedrich Matthias, Brand Stephan
CEACAM6 gene variants in inflammatory bowel disease
Glas J, Czamara D, Diegelmann J, Müller-Myhsok B, Lohse P, Wolf C, Ochsenkühn T, Göke B, Lass U, Olszak T, Beigel F, Weidinger M, Pfennig S, Tillack C, Fries C, Seiderer J, Brand S. CEACAM6 gene variants in inflammatory bowel disease. PloS one 2011; 6:e19319.
29.04.2011CEACAM6 gene variants in inflammatory bowel disease
29.04.2011PloS one 2011; 6:e19319
Glas Jürgen, Czamara Darina, Diegelmann Julia, Müller-Myhsok Bertram, Lohse Peter, Wolf Christiane, Ochsenkühn Thomas, Göke Burkhard, Lass Ulrich, Olszak Torsten, Beigel Florian, Weidinger Maria, Pfennig Simone, Tillack Cornelia, Fries Christoph, Seiderer Julia, Brand Stephan
The NOD2 single nucleotide polymorphisms rs2066843 and rs2076756 are novel and common Crohn's disease susceptibility gene variants
Glas J, Czamara D, Diegelmann J, Lohse P, Ochsenkühn T, Göke B, Müller-Myhsok B, Weidinger M, Laubender R, Olszak T, Jürgens M, Beigel F, Pfennig S, Tillack C, Seiderer J, Brand S. The NOD2 single nucleotide polymorphisms rs2066843 and rs2076756 are novel and common Crohn's disease susceptibility gene variants. PloS one 2010; 5:e14466.
30.12.2010The NOD2 single nucleotide polymorphisms rs2066843 and rs2076756 are novel and common Crohn's disease susceptibility gene variants
30.12.2010PloS one 2010; 5:e14466
Glas Jürgen, Czamara Darina, Diegelmann Julia, Lohse Peter, Ochsenkühn Thomas, Göke Burkhard, Müller-Myhsok Bertram, Weidinger Maria, Laubender Rüdiger P, Olszak Torsten, Jürgens Matthias, Beigel Florian, Pfennig Simone, Tillack Cornelia, Seiderer Julia, Brand Stephan
Strong overexpression of CXCR3 axis components in childhood inflammatory bowel disease
Schroepf S, Koletzko S, von Schweinitz D, Berger M, Ballauff A, Helmbrecht J, Hoster E, Glas J, Lohse P, Prell C, Brand S, Kappler R, Lacher M. Strong overexpression of CXCR3 axis components in childhood inflammatory bowel disease. Inflamm Bowel Dis 2010; 16:1882-90.
01.11.2010Strong overexpression of CXCR3 axis components in childhood inflammatory bowel disease
01.11.2010Inflamm Bowel Dis 2010; 16:1882-90
Schroepf Sebastian, Koletzko Sibylle, von Schweinitz Dietrich, Berger Michael, Ballauff Antje, Helmbrecht Johanna, Hoster Eva, Glas Jürgen, Lohse Peter, Prell Christine, Brand Stephan, Kappler Roland, Lacher Martin
Evidence for STAT4 as a common autoimmune gene: rs7574865 is associated with colonic Crohn's disease and early disease onset
Glas J, Roeske D, Müller-Myhsok B, Diegelmann J, Ochsenkühn T, Göke B, Folwaczny M, Lohse P, Epplen J, Klein W, Pfennig S, Weidinger M, Beigel F, Fries C, Nagy M, Seiderer J, Brand S. Evidence for STAT4 as a common autoimmune gene: rs7574865 is associated with colonic Crohn's disease and early disease onset. PloS one 2010; 5:e10373.
29.04.2010Evidence for STAT4 as a common autoimmune gene: rs7574865 is associated with colonic Crohn's disease and early disease onset
29.04.2010PloS one 2010; 5:e10373
Glas Jürgen, Roeske Darina, Müller-Myhsok Bertram, Diegelmann Julia, Ochsenkühn Thomas, Göke Burkhard, Folwaczny Matthias, Lohse Peter, Epplen Jörg T, Klein Wolfram, Pfennig Simone, Weidinger Maria, Beigel Florian, Fries Christoph, Nagy Melinda, Seiderer Julia, Brand Stephan
The presence of fistulas and NOD2 homozygosity strongly predict intestinal stenosis in Crohn's disease independent of the IL23R genotype
Jürgens M, Herrmann K, Lohse P, Göke B, Kreis M, Schnitzler F, Weidinger M, Beigel F, Tillack C, Pfennig S, Wagner J, Wetzke M, Glas J, Seiderer J, Laubender R, Brand S, Ochsenkühn T. The presence of fistulas and NOD2 homozygosity strongly predict intestinal stenosis in Crohn's disease independent of the IL23R genotype. J Gastroenterol 2010; 45:721-31.
29.04.2010The presence of fistulas and NOD2 homozygosity strongly predict intestinal stenosis in Crohn's disease independent of the IL23R genotype
29.04.2010J Gastroenterol 2010; 45:721-31
Jürgens Matthias, Herrmann Karin, Lohse Peter, Göke Burkhard, Kreis Martin E, Schnitzler Fabian, Weidinger Maria, Beigel Florian, Tillack Cornelia, Pfennig Simone, Wagner Johanna, Wetzke Martin, Glas Jürgen, Seiderer Julia, Laubender Rüdiger P, Brand Stephan, Ochsenkühn Thomas
Disease activity, ANCA, and IL23R genotype status determine early response to infliximab in patients with ulcerative colitis
Jürgens M, Ochsenkühn T, Glas J, Göke B, Lohse P, Tillack C, Schnitzler F, Stallhofer J, Pfennig S, Beigel F, Wetzke M, Wagner J, Seiderer J, Weidinger M, Hartl F, Laubender R, Brand S. Disease activity, ANCA, and IL23R genotype status determine early response to infliximab in patients with ulcerative colitis. Am J Gastroenterol 2010; 105:1811-9.
02.03.2010Disease activity, ANCA, and IL23R genotype status determine early response to infliximab in patients with ulcerative colitis
02.03.2010Am J Gastroenterol 2010; 105:1811-9
Jürgens Matthias, Ochsenkühn Thomas, Glas Jürgen, Göke Burkhard, Lohse Peter, Tillack Cornelia, Schnitzler Fabian, Stallhofer Johannes, Pfennig Simone, Beigel Florian, Wetzke Martin, Wagner Johanna, Seiderer Julia, Weidinger Maria, Hartl Franziska, Laubender Rüdiger P, Brand Stephan
The cannabinoid 1 receptor (CNR1) 1359 G/A polymorphism modulates susceptibility to ulcerative colitis and the phenotype in Crohn's disease
Storr M, Emmerdinger D, Diegelmann J, Pfennig S, Ochsenkühn T, Göke B, Lohse P, Brand S. The cannabinoid 1 receptor (CNR1) 1359 G/A polymorphism modulates susceptibility to ulcerative colitis and the phenotype in Crohn's disease. PloS one 2010; 5:e9453.
26.02.2010The cannabinoid 1 receptor (CNR1) 1359 G/A polymorphism modulates susceptibility to ulcerative colitis and the phenotype in Crohn's disease
26.02.2010PloS one 2010; 5:e9453
Storr Martin, Emmerdinger Dominik, Diegelmann Julia, Pfennig Simone, Ochsenkühn Thomas, Göke Burkhard, Lohse Peter, Brand Stephan
Epistasis between Toll-like receptor-9 polymorphisms and variants in NOD2 and IL23R modulates susceptibility to Crohn's disease
Török H, Müller-Myhsok B, Folwaczny C, Göke B, Folwaczny M, Ochsenkühn T, Lohse P, Klein W, Wetzke M, Teshome M, Tonenchi L, Endres I, Glas J, Brand S. Epistasis between Toll-like receptor-9 polymorphisms and variants in NOD2 and IL23R modulates susceptibility to Crohn's disease. Am J Gastroenterol 2009; 104:1723-33.
19.05.2009Epistasis between Toll-like receptor-9 polymorphisms and variants in NOD2 and IL23R modulates susceptibility to Crohn's disease
19.05.2009Am J Gastroenterol 2009; 104:1723-33
Török Helga P, Müller-Myhsok Bertram, Folwaczny Christian, Göke Burkhard, Folwaczny Matthias, Ochsenkühn Thomas, Lohse Peter, Klein Wolfram, Wetzke Martin, Teshome Molla Y, Tonenchi Laurian, Endres Ilona, Glas Jürgen, Brand Stephan
Novel genetic risk markers for ulcerative colitis in the IL2/IL21 region are in epistasis with IL23R and suggest a common genetic background for ulcerative colitis and celiac disease
Glas J, Müller-Myhsok B, Ochsenkühn T, Göke B, Lohse P, Folwaczny M, Koletzko S, Lacher M, Schiemann U, Griga T, Epplen J, Klein W, Pfennig S, Wetzke M, Ripke S, Stallhofer J, Brand S. Novel genetic risk markers for ulcerative colitis in the IL2/IL21 region are in epistasis with IL23R and suggest a common genetic background for ulcerative colitis and celiac disease. Am J Gastroenterol 2009; 104:1737-44.
19.05.2009Novel genetic risk markers for ulcerative colitis in the IL2/IL21 region are in epistasis with IL23R and suggest a common genetic background for ulcerative colitis and celiac disease
19.05.2009Am J Gastroenterol 2009; 104:1737-44
Glas Jürgen, Müller-Myhsok Bertram, Ochsenkühn Thomas, Göke Burkhard, Lohse Peter, Folwaczny Matthias, Koletzko Sibylle, Lacher Martin, Schiemann Uwe, Griga Thomas, Epplen Jörg T, Klein Wolfram, Pfennig Simone, Wetzke Martin, Ripke Stephan, Stallhofer Johannes, Brand Stephan
rs224136 on chromosome 10q21.1 and variants in PHOX2B, NCF4, and FAM92B are not major genetic risk factors for susceptibility to Crohn's disease in the German population
Glas J, Klein W, Epplen J, Schiemann U, Mussack T, Lohse P, Göke B, Ochsenkühn T, Folwaczny M, Müller-Myhsok B, Griga T, Jürgens M, Stallhofer J, Seiderer J, Pasciuto G, Tillack C, Diegelmann J, Pfennig S, Konrad A, Schmechel S, Wetzke M, Török H, Brand S. rs224136 on chromosome 10q21.1 and variants in PHOX2B, NCF4, and FAM92B are not major genetic risk factors for susceptibility to Crohn's disease in the German population. Am J Gastroenterol 2009; 104:665-72.
03.02.2009rs224136 on chromosome 10q21.1 and variants in PHOX2B, NCF4, and FAM92B are not major genetic risk factors for susceptibility to Crohn's disease in the German population
03.02.2009Am J Gastroenterol 2009; 104:665-72
Glas Jürgen, Klein Wolfram, Epplen Jörg T, Schiemann Uwe, Mussack Thomas, Lohse Peter, Göke Burkhard, Ochsenkühn Thomas, Folwaczny Matthias, Müller-Myhsok Bertram, Griga Thomas, Jürgens Matthias, Stallhofer Johannes, Seiderer Julia, Pasciuto Giulia, Tillack Cornelia, Diegelmann Julia, Pfennig Simone, Konrad Astrid, Schmechel Silke, Wetzke Martin, Török Helga-Paula, Brand Stephan
NOD2/CARD15 genotype influences MDP-induced cytokine release and basal IL-12p40 levels in primary isolated peripheral blood monocytes
Beynon V, Glas J, Folwaczny C, Folwaczny M, Ochsenkühn T, Mussack T, Wagner S, Mair A, Lohse P, Brand S, Cotofana S, Török H. NOD2/CARD15 genotype influences MDP-induced cytokine release and basal IL-12p40 levels in primary isolated peripheral blood monocytes. Inflamm Bowel Dis 2008; 14:1033-40.
01.08.2008NOD2/CARD15 genotype influences MDP-induced cytokine release and basal IL-12p40 levels in primary isolated peripheral blood monocytes
01.08.2008Inflamm Bowel Dis 2008; 14:1033-40
Beynon Vanessa, Glas Jürgen, Folwaczny Christian, Folwaczny Matthias, Ochsenkühn Thomas, Mussack Thomas, Wagner Stefanie, Mair Anja, Lohse Peter, Brand Stephan, Cotofana Sebastian, Török Helga-Paula
Role of the novel Th17 cytokine IL-17F in inflammatory bowel disease (IBD): upregulated colonic IL-17F expression in active Crohn's disease and analysis of the IL17F p.His161Arg polymorphism in IBD
Seiderer J, Lohse P, Müller-Myhsok B, Ochsenkühn T, Göke B, Konrad A, Schmechel S, Jürgens M, Pfennig S, Tillack C, Stallhofer J, Glas J, Diegelmann J, Elben I, Brand S. Role of the novel Th17 cytokine IL-17F in inflammatory bowel disease (IBD): upregulated colonic IL-17F expression in active Crohn's disease and analysis of the IL17F p.His161Arg polymorphism in IBD. Inflamm Bowel Dis 2008; 14:437-45.
01.04.2008Role of the novel Th17 cytokine IL-17F in inflammatory bowel disease (IBD): upregulated colonic IL-17F expression in active Crohn's disease and analysis of the IL17F p.His161Arg polymorphism in IBD
01.04.2008Inflamm Bowel Dis 2008; 14:437-45
Seiderer Julia, Lohse Peter, Müller-Myhsok Bertram, Ochsenkühn Thomas, Göke Burkhard, Konrad Astrid, Schmechel Silke, Jürgens Matthias, Pfennig Simone, Tillack Cornelia, Stallhofer Johannes, Glas Jürgen, Diegelmann Julia, Elben Ira, Brand Stephan
Linking genetic susceptibility to Crohn's disease with Th17 cell function: IL-22 serum levels are increased in Crohn's disease and correlate with disease activity and IL23R genotype status
Schmechel S, Konrad A, Diegelmann J, Glas J, Wetzke M, Paschos E, Lohse P, Göke B, Brand S. Linking genetic susceptibility to Crohn's disease with Th17 cell function: IL-22 serum levels are increased in Crohn's disease and correlate with disease activity and IL23R genotype status. Inflamm Bowel Dis 2008; 14:204-12.
01.02.2008Linking genetic susceptibility to Crohn's disease with Th17 cell function: IL-22 serum levels are increased in Crohn's disease and correlate with disease activity and IL23R genotype status
01.02.2008Inflamm Bowel Dis 2008; 14:204-12
Schmechel Silke, Konrad Astrid, Diegelmann Julia, Glas Jürgen, Wetzke Martin, Paschos Ekaterini, Lohse Peter, Göke Burkhard, Brand Stephan
Genotype-phenotype analysis of the CXCL16 p.Ala181Val polymorphism in inflammatory bowel disease
Seiderer J, Reinecker H, Lohse P, Ochsenkühn T, Göke B, Müller-Myhsok B, Jürgens M, Pfennig S, Niess J, Glas J, Tillack C, Leistner D, Dambacher J, Brand S. Genotype-phenotype analysis of the CXCL16 p.Ala181Val polymorphism in inflammatory bowel disease. Clin Immunol 2008; 127:49-55.
11.01.2008Genotype-phenotype analysis of the CXCL16 p.Ala181Val polymorphism in inflammatory bowel disease
11.01.2008Clin Immunol 2008; 127:49-55
Seiderer Julia, Reinecker Hans-Christian, Lohse Peter, Ochsenkühn Thomas, Göke Burkhard, Müller-Myhsok Bertram, Jürgens Matthias, Pfennig Simone, Niess Jan-Hendrik, Glas Jürgen, Tillack Cornelia, Leistner Dorothea, Dambacher Julia, Brand Stephan
The ATG16L1 gene variants rs2241879 and rs2241880 (T300A) are strongly associated with susceptibility to Crohn's disease in the German population
Glas J, Klein W, Epplen J, Folwaczny C, Lohse P, Göke B, Ochsenkühn T, Mussack T, Folwaczny M, Müller-Myhsok B, Griga T, Haller D, Pfennig S, Konrad A, Schmechel S, Dambacher J, Seiderer J, Schroff F, Wetzke M, Roeske D, Török H, Tonenchi L, Brand S. The ATG16L1 gene variants rs2241879 and rs2241880 (T300A) are strongly associated with susceptibility to Crohn's disease in the German population. Am J Gastroenterol 2007; 103:682-91.
20.12.2007The ATG16L1 gene variants rs2241879 and rs2241880 (T300A) are strongly associated with susceptibility to Crohn's disease in the German population
20.12.2007Am J Gastroenterol 2007; 103:682-91
Glas Jürgen, Klein Wolfram, Epplen Jörg T, Folwaczny Christian, Lohse Peter, Göke Burkhard, Ochsenkühn Thomas, Mussack Thomas, Folwaczny Matthias, Müller-Myhsok Bertram, Griga Thomas, Haller Dirk, Pfennig Simone, Konrad Astrid, Schmechel Silke, Dambacher Julia, Seiderer Julia, Schroff Frieder, Wetzke Martin, Roeske Darina, Török Helga-Paula, Tonenchi Laurian, Brand Stephan
rs1004819 is the main disease-associated IL23R variant in German Crohn's disease patients: combined analysis of IL23R, CARD15, and OCTN1/2 variants
Glas J, Epplen J, Schiemann U, Folwaczny C, Lohse P, Göke B, Ochsenkühn T, Müller-Myhsok B, Folwaczny M, Mussack T, Klein W, Griga T, Maier K, Seiderer J, Wetzke M, Konrad A, Török H, Schmechel S, Tonenchi L, Grassl C, Dambacher J, Pfennig S, Brand S. rs1004819 is the main disease-associated IL23R variant in German Crohn's disease patients: combined analysis of IL23R, CARD15, and OCTN1/2 variants. PloS one 2007; 2:e819.
05.09.2007rs1004819 is the main disease-associated IL23R variant in German Crohn's disease patients: combined analysis of IL23R, CARD15, and OCTN1/2 variants
05.09.2007PloS one 2007; 2:e819
Glas Jürgen, Epplen Jörg T, Schiemann Uwe, Folwaczny Christian, Lohse Peter, Göke Burkhard, Ochsenkühn Thomas, Müller-Myhsok Bertram, Folwaczny Matthias, Mussack Thomas, Klein Wolfram, Griga Thomas, Maier Kerstin, Seiderer Julia, Wetzke Martin, Konrad Astrid, Török Helga-Paula, Schmechel Silke, Tonenchi Laurian, Grassl Christine, Dambacher Julia, Pfennig Simone, Brand Stephan