Bogdan I Florea
Treatment with HIV-Protease Inhibitor Nelfinavir Identifies Membrane Lipid Composition and Fluidity as a Therapeutic Target in Advanced Multiple Myeloma
Besse L, Pilon M, Farhan H, Vulpe C, Overkleeft H, Driessen C, Ståhlman M, Huber J, Bolomsky A, Ludwig H, Hannich J, Loguinov A, Everts B, Berkers C, Besse A, Borén J, Florea B, Sathianathan M, Stolze S, Sobh A, Zaal E, van der Ham A, Ruiz M, Phuyal S, Büchler L. Treatment with HIV-Protease Inhibitor Nelfinavir Identifies Membrane Lipid Composition and Fluidity as a Therapeutic Target in Advanced Multiple Myeloma. Cancer Res 2021; 81:4581-4593.
22.06.2021Treatment with HIV-Protease Inhibitor Nelfinavir Identifies Membrane Lipid Composition and Fluidity as a Therapeutic Target in Advanced Multiple Myeloma
22.06.2021Cancer Res 2021; 81:4581-4593
Besse Lenka, Pilon Marc, Farhan Hesso, Vulpe Christopher D, Overkleeft Herman S, Driessen Christoph, Ståhlman Marcus, Huber Julia, Bolomsky Arnold, Ludwig Heinz, Hannich J Thomas, Loguinov Alex, Everts Bart, Berkers Celia R, Besse Andrej, Borén Jan, Florea Bogdan I, Sathianathan Marc, Stolze Sara C, Sobh Amin, Zaal Esther A, van der Ham Alwin J, Ruiz Mario, Phuyal Santosh, Büchler Lorina
Structure-Based Design of Inhibitors Selective for Human Proteasome β2c or β2i Subunits
Xin B, Groll M, van der Marel G, Driessen C, Florea B, Kisselev A, Weyburne E, Janssens M, Du Y, Espinal C, Maurits E, Heinemeyer W, de Bruin G, Huber E, Overkleeft H. Structure-Based Design of Inhibitors Selective for Human Proteasome β2c or β2i Subunits. J Med Chem 2019; 62:1626-1642.
05.02.2019Structure-Based Design of Inhibitors Selective for Human Proteasome β2c or β2i Subunits
05.02.2019J Med Chem 2019; 62:1626-1642
Xin Bo-Tao, Groll Michael, van der Marel Gijsbert A, Driessen Christoph, Florea Bogdan I, Kisselev Alexei F, Weyburne Emily S, Janssens Marissa, Du Yimeng, Espinal Christofer, Maurits Elmer, Heinemeyer Wolfgang, de Bruin Gerjan, Huber Eva M, Overkleeft Herman S
An inhibitor of proteasome β2 sites sensitizes myeloma cells to immunoproteasome inhibitors
Downey-Kopyscinski S, Overkleeft H, Driessen C, Richardson P, Mitsiades C, Florea B, Bhatt A, Gautier M, Daily E, Kisselev A. An inhibitor of proteasome β2 sites sensitizes myeloma cells to immunoproteasome inhibitors. Blood Adv 2018; 2:2443-2451.
09.10.2018An inhibitor of proteasome β2 sites sensitizes myeloma cells to immunoproteasome inhibitors
09.10.2018Blood Adv 2018; 2:2443-2451
Downey-Kopyscinski Sondra, Overkleeft Herman S, Driessen Christoph, Richardson Paul G, Mitsiades Constantine S, Florea Bogdan I, Bhatt Ananta, Gautier Marc, Daily Ellen W, Kisselev Alexei F
Structure-Based Design of β5c Selective Inhibitors of Human Constitutive Proteasomes
Xin B, Groll M, Driessen C, van der Stelt M, Kisselev A, van der Marel G, Filippov D, Florea B, Besse A, Huber E, de Bruin G, Overkleeft H. Structure-Based Design of β5c Selective Inhibitors of Human Constitutive Proteasomes. J Med Chem 2016; 59:7177-87.
01.08.2016Structure-Based Design of β5c Selective Inhibitors of Human Constitutive Proteasomes
01.08.2016J Med Chem 2016; 59:7177-87
Xin Bo-Tao, Groll Michael, Driessen Christoph, van der Stelt Mario, Kisselev Alexei F, van der Marel Gijsbert A, Filippov Dmitri V, Florea Bogdan I, Besse Andrej, Huber Eva M, de Bruin Gerjan, Overkleeft Herman S
Development of new Malt1 inhibitors and probes
Xin B, Schimmack G, Du Y, Florea B, van der Marel G, Driessen C, Krappmann D, Overkleeft H. Development of new Malt1 inhibitors and probes. Bioorg Med Chem 2016; 24:3312-29.
28.03.2016Development of new Malt1 inhibitors and probes
28.03.2016Bioorg Med Chem 2016; 24:3312-29
Xin Bo-Tao, Schimmack Gisela, Du Yimeng, Florea Bogdan I, van der Marel Gijsbert A, Driessen Christoph, Krappmann Daniel, Overkleeft Herman S
A Set of Activity-Based Probes to Visualize Human (Immuno)proteasome Activities
de Bruin G, Xin B, Kraus M, van der Stelt M, van der Marel G, Kisselev A, Driessen C, Florea B, Overkleeft H. A Set of Activity-Based Probes to Visualize Human (Immuno)proteasome Activities. Angew Chem Int Ed Engl 2015; 55:4199-203.
29.10.2015A Set of Activity-Based Probes to Visualize Human (Immuno)proteasome Activities
29.10.2015Angew Chem Int Ed Engl 2015; 55:4199-203
de Bruin Gerjan, Xin Bo Tao, Kraus Marianne, van der Stelt Mario, van der Marel Gijsbert A, Kisselev Alexei F, Driessen Christoph, Florea Bogdan I, Overkleeft Herman S
Incorporation of non-natural amino acids improves cell permeability and potency of specific inhibitors of proteasome trypsin-like sites
Geurink P, Overkleeft H, Groll M, van der Stelt M, Driessen C, van der Marel G, Florea B, Mock E, Voges M, Blom A, de Bruin G, Gallastegui N, Mirabella A, van der Linden W, Kisselev A. Incorporation of non-natural amino acids improves cell permeability and potency of specific inhibitors of proteasome trypsin-like sites. J Med Chem 2013; 56:1262-75.
28.01.2013Incorporation of non-natural amino acids improves cell permeability and potency of specific inhibitors of proteasome trypsin-like sites
28.01.2013J Med Chem 2013; 56:1262-75
Geurink Paul P, Overkleeft Herman S, Groll Michael, van der Stelt Mario, Driessen Christoph, van der Marel Gijs A, Florea Bogdan I, Mock Elliot D, Voges Mathias J, Blom Annet E M, de Bruin Gerjan, Gallastegui Nerea, Mirabella Anne C, van der Linden Wouter A, Kisselev Alexei F
Syringolin A selectively labels the 20 S proteasome in murine EL4 and wild-type and bortezomib-adapted leukaemic cell lines
Clerc J, Overkleeft H, Driessen C, Dudler R, Bachmann A, Huber R, Groll M, Kraus M, Florea B, Kaiser M. Syringolin A selectively labels the 20 S proteasome in murine EL4 and wild-type and bortezomib-adapted leukaemic cell lines. Chembiochem : a European journal of chemical biology 2009; 10:2638-43.
02.11.2009Syringolin A selectively labels the 20 S proteasome in murine EL4 and wild-type and bortezomib-adapted leukaemic cell lines
02.11.2009Chembiochem : a European journal of chemical biology 2009; 10:2638-43
Clerc Jérôme, Overkleeft Herman S, Driessen Christoph, Dudler Robert, Bachmann André S, Huber Robert, Groll Michael, Kraus Marianne, Florea Bogdan I, Kaiser Markus
Receptor-mediated targeting of cathepsins in professional antigen presenting cells
Hillaert U, Driessen C, van der Marel G, Ossendorp F, Van Calenbergh S, Kuiper J, Habets K, Saragliadis A, Saragliadis A, Florea B, Verdoes M, Overkleeft H. Receptor-mediated targeting of cathepsins in professional antigen presenting cells. Angewandte Chemie (International ed. in English) 2009; 48:1629-32.
01.01.2009Receptor-mediated targeting of cathepsins in professional antigen presenting cells
01.01.2009Angewandte Chemie (International ed. in English) 2009; 48:1629-32
Hillaert Ulrik, Driessen Christoph, van der Marel Gijsbert A, Ossendorp Ferry, Van Calenbergh Serge, Kuiper Johan, Habets Kim L L, Saragliadis Anastasios, Saragliadis Athanasios, Florea Bogdan I, Verdoes Martijn, Overkleeft Hermen S