PhD Natalia Pikor
Group Leader Neuroimmunology,
Institut für Immunbiologie, Medizinisches Forschungszentrum, KSSG, CH
Assistant Professor Neuroimmunology,
Institut für Microbiology, D-BIOL, ETH Zürich, CH
Leitende(r) Wissenschaftler/in
Institut für Immunbiologie, Medizinisches Forschungszentrum · Dept. Direktion
Conserved stromal-immune cell circuits secure B cell homeostasis and function.
Lütge M, De Martin A, Gil Cruz C, Pérez Shibayama C, Stanossek Y, Onder L, Cheng H, Kurz L, Cadosch N, Soneson C, Robinson M, Stöckli S, Ludewig B, Pikor N. Conserved stromal-immune cell circuits secure B cell homeostasis and function. Nat Immunol 2023
18.05.2023Conserved stromal-immune cell circuits secure B cell homeostasis and function.
18.05.2023Nat Immunol 2023
Lütge Mechthild, De Martin Angelina, Gil Cruz Cristina, Pérez Shibayama Christian Ivan, Stanossek Yves, Onder Lucas, Cheng Hung-Wei, Kurz Lisa, Cadosch Nadine, Soneson Charlotte, Robinson Mark D, Stöckli Sandro, Ludewig Burkhard, Pikor Natalia
PI16 reticular cells in human palatine tonsils govern T cell activity in distinct subepithelial niches.
De Martin A, Stanossek Y, Lütge M, Cadosch N, Onder L, Cheng H, Brandstadter J, Maillard I, Stöckli S, Pikor N, Ludewig B. PI16 reticular cells in human palatine tonsils govern T cell activity in distinct subepithelial niches. Nat Immunol 2023; 24:1138-1148.
18.05.2023PI16 reticular cells in human palatine tonsils govern T cell activity in distinct subepithelial niches.
18.05.2023Nat Immunol 2023; 24:1138-1148
De Martin Angelina, Stanossek Yves, Lütge Mechthild, Cadosch Nadine, Onder Lucas, Cheng Hung-Wei, Brandstadter Joshua D, Maillard Ivan, Stöckli Sandro, Pikor Natalia, Ludewig Burkhard
An Innate Checkpoint Determines Immune Dysregulation and Immunopathology during Pulmonary Murine Coronavirus Infection.
Grabherr S, Waltenspühl A, Büchler L, Lütge M, Cheng H, Caviezel-Firner S, Ludewig B, Krebs P, Pikor N. An Innate Checkpoint Determines Immune Dysregulation and Immunopathology during Pulmonary Murine Coronavirus Infection. J Immunol 2023; 210:774-785.
15.03.2023An Innate Checkpoint Determines Immune Dysregulation and Immunopathology during Pulmonary Murine Coronavirus Infection.
15.03.2023J Immunol 2023; 210:774-785
Grabherr Sarah, Waltenspühl Alexandra, Büchler Lorina, Lütge Mechthild, Cheng Hung-Wei, Caviezel-Firner Sonja, Ludewig Burkhard, Krebs Philippe, Pikor Natalia
Postvaccination anti-S IgG levels predict anti-SARS-CoV-2 neutralising activity over 24 weeks in patients with RA.
Schmiedeberg K, Abela I, Pikor N, Vuilleumier N, Schwarzmueller M, Epp S, Pagano S, Grabherr S, Patterson A, Nussberger M, Trkola A, Ludewig B, von Kempis J, Rubbert-Roth A. Postvaccination anti-S IgG levels predict anti-SARS-CoV-2 neutralising activity over 24 weeks in patients with RA. RMD Open 2022; 8
01.01.2022Postvaccination anti-S IgG levels predict anti-SARS-CoV-2 neutralising activity over 24 weeks in patients with RA.
01.01.2022RMD Open 2022; 8
Schmiedeberg Kristin, Abela Irene A, Pikor Natalia, Vuilleumier Nicolas, Schwarzmueller Magdalena, Epp Selina, Pagano Sabrina, Grabherr Sarah, Patterson Angelica Brooke, Nussberger Madalina, Trkola Alexandra, Ludewig Burkhard, von Kempis Johannes, Rubbert-Roth Andrea
Differentiation and activation of fibroblastic reticular cells
Lütge M, Pikor N, Ludewig B. Differentiation and activation of fibroblastic reticular cells. Immunol Rev 2021; 302:32-46.
27.05.2021Differentiation and activation of fibroblastic reticular cells
27.05.2021Immunol Rev 2021; 302:32-46
Lütge Mechthild, Pikor Natalia, Ludewig Burkhard
Insights into coronavirus immunity taught by the murine coronavirus
Grabherr S, Ludewig B, Pikor N. Insights into coronavirus immunity taught by the murine coronavirus. Eur J Immunol 2021; 51:1062-1070.
22.03.2021Insights into coronavirus immunity taught by the murine coronavirus
22.03.2021Eur J Immunol 2021; 51:1062-1070
Grabherr Sarah, Ludewig Burkhard, Pikor Natalia
Development and Immunological Function of Lymph Node Stromal Cells
Pikor N, Cheng H, Onder L, Ludewig B. Development and Immunological Function of Lymph Node Stromal Cells. J Immunol 2021; 206:257-263.
15.01.2021Development and Immunological Function of Lymph Node Stromal Cells
15.01.2021J Immunol 2021; 206:257-263
Pikor Natalia, Cheng Hung-Wei, Onder Lucas, Ludewig Burkhard
B cell zone reticular cell microenvironments shape CXCL13 gradient formation
Cosgrove J, Uguccioni M, Legler D, Lacey C, Coatesworth A, Polak W, Cupedo T, Manoury B, Thelen M, Stein J, Wolf M, Leake M, Timmis J, Ludewig B, Heller M, Venetz D, Taylor E, Novkovic M, Albrecht S, Pikor N, Zhou Z, Onder L, Mörbe U, Cupovic J, Miller H, Alden K, Thuery A, O'Toole P, Pinter R, Jarrett S, Coles M. B cell zone reticular cell microenvironments shape CXCL13 gradient formation. Nat Commun 2020; 11:3677.
22.07.2020B cell zone reticular cell microenvironments shape CXCL13 gradient formation
22.07.2020Nat Commun 2020; 11:3677
Cosgrove Jason, Uguccioni Mariagrazia, Legler Daniel F, Lacey Charles J, Coatesworth Andrew, Polak Wojciech G, Cupedo Tom, Manoury Bénedicte, Thelen Marcus, Stein Jens V, Wolf Marlene, Leake Mark C, Timmis Jon, Ludewig Burkhard, Heller Manfred, Venetz Daniel, Taylor Emily, Novkovic Mario, Albrecht Stefan, Pikor Natalia, Zhou Zhaoukun, Onder Lucas, Mörbe Urs, Cupovic Jovana, Miller Helen, Alden Kieran, Thuery Anne, O'Toole Peter, Pinter Rita, Jarrett Simon, Coles Mark C
Remodeling of light and dark zone follicular dendritic cells governs germinal center responses
Pikor N, Onder L, Linterman M, Nagasawa T, Nombela-Arrieta C, Cheng H, Novkovic M, Pérez Shibayama C, Gil Cruz C, Lütge M, Mörbe U, Ludewig B. Remodeling of light and dark zone follicular dendritic cells governs germinal center responses. Nat Immunol 2020; 21:649-659.
18.05.2020Remodeling of light and dark zone follicular dendritic cells governs germinal center responses
18.05.2020Nat Immunol 2020; 21:649-659
Pikor Natalia, Onder Lucas, Linterman Michelle A, Nagasawa Takashi, Nombela-Arrieta César, Cheng Hung-Wei, Novkovic Mario, Pérez Shibayama Christian Ivan, Gil Cruz Cristina, Lütge Mechthild, Mörbe Urs, Ludewig Burkhard
Type I Interferon Signaling Disrupts the Hepatic Urea Cycle and Alters Systemic Metabolism to Suppress T Cell Function
Lercher A, Pikor N, Reil D, Ozsvár-Kozma M, Kalinke U, Ludewig B, Moriggl R, Bennett K, Menche J, Cheng P, Schabbauer G, Trauner M, Klavins K, Orlova A, Genger J, Bhattacharya A, Popa A, Caldera M, Schlapansky M, Baazim H, Agerer B, Gürtl B, Kosack L, Májek P, Brunner J, Vitko D, Pinter T, Bergthaler A. Type I Interferon Signaling Disrupts the Hepatic Urea Cycle and Alters Systemic Metabolism to Suppress T Cell Function. Immunity 2019; 51:1074-1087.e9.
26.11.2019Type I Interferon Signaling Disrupts the Hepatic Urea Cycle and Alters Systemic Metabolism to Suppress T Cell Function
26.11.2019Immunity 2019; 51:1074-1087.e9
Lercher Alexander, Pikor Natalia, Reil Daniela, Ozsvár-Kozma Maria, Kalinke Ulrich, Ludewig Burkhard, Moriggl Richard, Bennett Keiryn L, Menche Jörg, Cheng Paul N, Schabbauer Gernot, Trauner Michael, Klavins Kristaps, Orlova Anna, Genger Jakob-Wendelin, Bhattacharya Anannya, Popa Alexandra M, Caldera Michael, Schlapansky Moritz F, Baazim Hatoon, Agerer Benedikt, Gürtl Bettina, Kosack Lindsay, Májek Peter, Brunner Julia S, Vitko Dijana, Pinter Theresa, Bergthaler Andreas
Association of Checkpoint Inhibitor-Induced Toxic Effects With Shared Cancer and Tissue Antigens in Non-Small Cell Lung Cancer
Berner F, Hartmann F, Cheng H, Hönger G, Recher M, Goldman J, Cozzio A, Früh M, Neefjes J, Driessen C, Ludewig B, Hegazy A, Jochum W, Speiser D, Zippelius A, Läubli H, Bomze D, Diem S, Ali O, Fässler M, Ring S, Niederer R, Ackermann C, Baumgaertner P, Pikor N, Cruz C, van de Veen W, Akdis M, Nikolaev S, Flatz L. Association of Checkpoint Inhibitor-Induced Toxic Effects With Shared Cancer and Tissue Antigens in Non-Small Cell Lung Cancer. JAMA Oncol 2019; 5:1043-1047.
01.07.2019Association of Checkpoint Inhibitor-Induced Toxic Effects With Shared Cancer and Tissue Antigens in Non-Small Cell Lung Cancer
01.07.2019JAMA Oncol 2019; 5:1043-1047
Berner Fiamma, Hartmann Fabienne, Cheng Hung-Wei, Hönger Gideon, Recher Mike, Goldman Jonathan, Cozzio Antonio, Früh Martin, Neefjes Jacques, Driessen Christoph, Ludewig Burkhard, Hegazy Ahmed N, Jochum Wolfram, Speiser Daniel E, Zippelius Alfred, Läubli Heinz, Bomze David, Diem Stefan, Ali Omar Hasan, Fässler Mirjam, Ring Sandra, Niederer Rebekka, Ackermann Christoph J, Baumgaertner Petra, Pikor Natalia, Cruz Cristina Gil, van de Veen Willem, Akdis Mübeccel, Nikolaev Sergey, Flatz Lukas
Origin and differentiation trajectories of fibroblastic reticular cells in the splenic white pulp
Cheng H, Hehlgans T, Rülicke T, Pfeffer K, Sorg U, Tersteegen A, Miyazaki J, Robinson M, Scandella E, Pikor N, Lütge M, Soneson C, Novkovic M, Onder L, Ludewig B. Origin and differentiation trajectories of fibroblastic reticular cells in the splenic white pulp. Nat Commun 2019; 10:1739.
15.04.2019Origin and differentiation trajectories of fibroblastic reticular cells in the splenic white pulp
15.04.2019Nat Commun 2019; 10:1739
Cheng Hung-Wei, Hehlgans Thomas, Rülicke Thomas, Pfeffer Klaus, Sorg Ursula, Tersteegen Anne, Miyazaki Jun-Ichi, Robinson Mark D, Scandella Elke, Pikor Natalia, Lütge Mechthild, Soneson Charlotte, Novkovic Mario, Onder Lucas, Ludewig Burkhard
CCL19-producing fibroblastic stromal cells restrain lung carcinoma growth by promoting local antitumor T-cell responses
Cheng H, Brutsche M, Jochum W, Schneider T, Rodriguez R, Tarantino I, Pikor N, Novkovic M, Bösch M, Cupovic J, Onder L, Ludewig B. CCL19-producing fibroblastic stromal cells restrain lung carcinoma growth by promoting local antitumor T-cell responses. J Allergy Clin Immunol 2018
31.01.2018CCL19-producing fibroblastic stromal cells restrain lung carcinoma growth by promoting local antitumor T-cell responses
31.01.2018J Allergy Clin Immunol 2018
Cheng Hung-Wei, Brutsche Martin, Jochum Wolfram, Schneider Tino, Rodriguez Regulo, Tarantino Ignazio, Pikor Natalia, Novkovic Mario, Bösch Maximilian, Cupovic Jovana, Onder Lucas, Ludewig Burkhard
Lymphatic Endothelial Cells Control Initiation of Lymph Node Organogenesis
Onder L, Scandella E, Sawa S, Mueller C, Gommerman J, Rülicke T, Waisman A, Becher B, Pfeffer K, Hehlgans T, Cheng H, Novkovic M, Pikor N, Mörbe U, Ludewig B. Lymphatic Endothelial Cells Control Initiation of Lymph Node Organogenesis. Immunity 2017; 47:80-92.e4.
11.07.2017Lymphatic Endothelial Cells Control Initiation of Lymph Node Organogenesis
11.07.2017Immunity 2017; 47:80-92.e4
Onder Lucas, Scandella Elke, Sawa Shinichiro, Mueller Christopher G, Gommerman Jennifer, Rülicke Thomas, Waisman Ari, Becher Burkhard, Pfeffer Klaus, Hehlgans Thomas, Cheng Hung-Wei, Novkovic Mario, Pikor Natalia, Mörbe Urs, Ludewig Burkhard
Stromal Cell Niches in the Inflamed Central Nervous System
Pikor N, Cupovic J, Onder L, Gommerman J, Ludewig B. Stromal Cell Niches in the Inflamed Central Nervous System. J Immunol 2017; 198:1775-1781.
01.03.2017Stromal Cell Niches in the Inflamed Central Nervous System
01.03.2017J Immunol 2017; 198:1775-1781
Pikor Natalia, Cupovic Jovana, Onder Lucas, Gommerman Jennifer L, Ludewig Burkhard
Secondary B cell receptor diversification is necessary for T cell mediated neuro-inflammation during experimental autoimmune encephalomyelitis
Galicia G, Boulianne B, Pikor N, Martin A, Gommerman J. Secondary B cell receptor diversification is necessary for T cell mediated neuro-inflammation during experimental autoimmune encephalomyelitis. PloS one 2013; 8:e61478.
22.04.2013Secondary B cell receptor diversification is necessary for T cell mediated neuro-inflammation during experimental autoimmune encephalomyelitis
22.04.2013PloS one 2013; 8:e61478
Galicia Georgina, Boulianne Bryant, Pikor Natalia, Martin Alberto, Gommerman Jennifer L
A sphingosine-1-phosphate receptor 1-directed agonist reduces central nervous system inflammation in a plasmacytoid dendritic cell-dependent manner
Galicia-Rosas G, Pikor N, Schwartz J, Rojas O, Jian A, Summers-Deluca L, Ostrowski M, Nuesslein-Hildesheim B, Gommerman J. A sphingosine-1-phosphate receptor 1-directed agonist reduces central nervous system inflammation in a plasmacytoid dendritic cell-dependent manner. J Immunol 2012; 189:3700-6.
29.08.2012A sphingosine-1-phosphate receptor 1-directed agonist reduces central nervous system inflammation in a plasmacytoid dendritic cell-dependent manner
29.08.2012J Immunol 2012; 189:3700-6
Galicia-Rosas Georgina, Pikor Natalia, Schwartz Jordan A, Rojas Olga, Jian Allen, Summers-Deluca Leslie, Ostrowski Mario, Nuesslein-Hildesheim Barbara, Gommerman Jennifer L
Lymphotoxin-sensitive microenvironments in homeostasis and inflammation
Boulianne B, Porfilio E, Pikor N, Gommerman J. Lymphotoxin-sensitive microenvironments in homeostasis and inflammation. Front Immunol 2012; 3:243.
31.07.2012Lymphotoxin-sensitive microenvironments in homeostasis and inflammation
31.07.2012Front Immunol 2012; 3:243
Boulianne Bryant, Porfilio Elisa A, Pikor Natalia, Gommerman Jennifer L
B cells in MS: Why, where and how?
Pikor N, Gommerman J. B cells in MS: Why, where and how?. Mult Scler Relat Disord 2012; 1:123-30.
07.04.2012B cells in MS: Why, where and how?
07.04.2012Mult Scler Relat Disord 2012; 1:123-30
Pikor Natalia, Gommerman Jennifer L
Substrain differences reveal novel disease-modifying gene candidates that alter the clinical course of a rodent model of multiple sclerosis
deLuca L, Osborne L, Ousman S, Finlay T, Defreitas D, Ward L, Galicia-Rosas G, O'Leary J, Pikor N, Gommerman J. Substrain differences reveal novel disease-modifying gene candidates that alter the clinical course of a rodent model of multiple sclerosis. J Immunol 2010; 184:3174-85.
19.02.2010Substrain differences reveal novel disease-modifying gene candidates that alter the clinical course of a rodent model of multiple sclerosis
19.02.2010J Immunol 2010; 184:3174-85
deLuca Leslie E Summers, Osborne Lucy R, Ousman Shalina S, Finlay Trisha M, Defreitas Dustin, Ward Lesley A, Galicia-Rosas Georgina, O'Leary Jennifer, Pikor Natalia, Gommerman Jennifer L