TIME-CHF Investigators
Novel concept to guide systolic heart failure medication by repeated biomarker testing-results from TIME-CHF in context of predictive, preventive, and personalized medicine
Davarzani N, Brunner-La Rocca H, Peeters R, Pfisterer M, Zaugg C, Rolny V, Block D, de Boer R, Suter T, Karel J, Smirnov E, Rickenbacher P, Maeder M, Sanders-van Wijk S, TIME-CHF Investigators. Novel concept to guide systolic heart failure medication by repeated biomarker testing-results from TIME-CHF in context of predictive, preventive, and personalized medicine. EPMA J 2018; 9:161-173.
13.05.2018Novel concept to guide systolic heart failure medication by repeated biomarker testing-results from TIME-CHF in context of predictive, preventive, and personalized medicine
13.05.2018EPMA J 2018; 9:161-173
Davarzani Nasser, Brunner-La Rocca Hans-Peter, Peeters Ralf, Pfisterer Matthias E, Zaugg Christian, Rolny Vinzent, Block Dirk, de Boer Rudolf A, Suter Thomas, Karel Joël, Smirnov Evgueni, Rickenbacher Peter, Maeder Micha, Sanders-van Wijk Sandra, TIME-CHF Investigators
Circulating biomarkers of distinct pathophysiological pathways in heart failure with preserved vs. reduced left ventricular ejection fraction
Sanders-van Wijk S, van Empel V, Davarzani N, Maeder M, Handschin R, Pfisterer M, Brunner-La Rocca H, TIME-CHF Investigators. Circulating biomarkers of distinct pathophysiological pathways in heart failure with preserved vs. reduced left ventricular ejection fraction. Eur J Heart Fail 2015; 17:1006-14.
16.10.2015Circulating biomarkers of distinct pathophysiological pathways in heart failure with preserved vs. reduced left ventricular ejection fraction
16.10.2015Eur J Heart Fail 2015; 17:1006-14
Sanders-van Wijk S, van Empel V, Davarzani N, Maeder Micha, Handschin R, Pfisterer M E, Brunner-La Rocca H P, TIME-CHF Investigators
Improvement in left ventricular ejection fraction and reverse remodeling in elderly heart failure patients on intense NT-proBNP-guided therapy
Kaufmann B, Rocca H, Pfisterer M, Bernheim A, Nietlispach F, Bucher U, Maeder M, Min S, Goetschalckx K, TIME-CHF Investigators. Improvement in left ventricular ejection fraction and reverse remodeling in elderly heart failure patients on intense NT-proBNP-guided therapy. Int J Cardiol 2015; 191:286-93.
02.05.2015Improvement in left ventricular ejection fraction and reverse remodeling in elderly heart failure patients on intense NT-proBNP-guided therapy
02.05.2015Int J Cardiol 2015; 191:286-93
Kaufmann Beat A, Rocca Hans-Peter Brunner-La, Pfisterer Matthias E, Bernheim Alain M, Nietlispach Fabian, Bucher Urs, Maeder Micha, Min Son Y, Goetschalckx Kaatje, TIME-CHF Investigators
Differential Prognostic Impact of Resting Heart Rate in Older Compared to Younger Patients with Chronic Heart Failure - Insights from TIME-CHF
Zurek M, Brunner-La Rocca H, Pfisterer M, Jeker U, Handschin R, Abbühl H, Sanders-van Wijk S, Muzzarelli S, Rickli H, Maeder M, TIME-CHF Investigators. Differential Prognostic Impact of Resting Heart Rate in Older Compared to Younger Patients with Chronic Heart Failure - Insights from TIME-CHF. J Card Fail 2015
07.01.2015Differential Prognostic Impact of Resting Heart Rate in Older Compared to Younger Patients with Chronic Heart Failure - Insights from TIME-CHF
07.01.2015J Card Fail 2015
Zurek Marzena, Brunner-La Rocca Hans-Peter, Pfisterer Matthias, Jeker Urs, Handschin Rolf, Abbühl Heidi, Sanders-van Wijk Sandra, Muzzarelli Stefano, Rickli Hans, Maeder Micha, TIME-CHF Investigators
Long-term results of intensified, N-terminal-pro-B-type natriuretic peptide-guided versus symptom-guided treatment in elderly patients with heart failure: five-year follow-up from TIME-CHF
Sanders-van Wijk S, Brunner-La Rocca H, Pfisterer M, Peter M, Rickenbacher P, Erne P, Estlinbaum W, Rickli H, Nietlispach F, Maeder M, TIME-CHF Investigators. Long-term results of intensified, N-terminal-pro-B-type natriuretic peptide-guided versus symptom-guided treatment in elderly patients with heart failure: five-year follow-up from TIME-CHF. Circ Heart Fail 2013; 7:131-9.
18.12.2013Long-term results of intensified, N-terminal-pro-B-type natriuretic peptide-guided versus symptom-guided treatment in elderly patients with heart failure: five-year follow-up from TIME-CHF
18.12.2013Circ Heart Fail 2013; 7:131-9
Sanders-van Wijk Sandra, Brunner-La Rocca Hans-Peter, Pfisterer Matthias P, Peter Martin, Rickenbacher Peter, Erne Paul, Estlinbaum Werner, Rickli Hans, Nietlispach Fabian, Maeder Micha, TIME-CHF Investigators
Prognostic impact of systemic inflammatory diseases in elderly patients with congestive heart failure
Burkard T, Brunner-La Rocca H, Pfisterer M, Handschin R, Pittl U, Zaker R, Hack D, Follath F, Rickli H, Pfister O, TIME-CHF Investigators. Prognostic impact of systemic inflammatory diseases in elderly patients with congestive heart failure. QJM 2013; 107:131-8.
15.10.2013Prognostic impact of systemic inflammatory diseases in elderly patients with congestive heart failure
15.10.2013QJM 2013; 107:131-8
Burkard T, Brunner-La Rocca H-P, Pfisterer M, Handschin R, Pittl U, Zaker R, Hack D, Follath F, Rickli Hans, Pfister O, TIME-CHF Investigators
N-terminal pro brain natriuretic peptide-guided management in patients with heart failure and preserved ejection fraction: findings from the Trial of Intensified versus standard medical therapy in elderly patients with congestive heart failure (TIME-CHF)
Maeder M, Brunner-La Rocca H, Pfisterer M, Peter M, Vuilliomenet A, Erne P, Gutmann M, Abbühl H, Rickli H, Rickenbacher P, TIME-CHF Investigators. N-terminal pro brain natriuretic peptide-guided management in patients with heart failure and preserved ejection fraction: findings from the Trial of Intensified versus standard medical therapy in elderly patients with congestive heart failure (TIME-CHF). Eur J Heart Fail 2013; 15:1148-56.
08.05.2013N-terminal pro brain natriuretic peptide-guided management in patients with heart failure and preserved ejection fraction: findings from the Trial of Intensified versus standard medical therapy in elderly patients with congestive heart failure (TIME-CHF)
08.05.2013Eur J Heart Fail 2013; 15:1148-56
Maeder Micha, Brunner-La Rocca Hans-Peter, Pfisterer Matthias, Peter Martin, Vuilliomenet André, Erne Paul, Gutmann Marc, Abbühl Heidi, Rickli Hans, Rickenbacher Peter, TIME-CHF Investigators
Cognitive impairment in heart failure: results from the Trial of Intensified versus standard Medical therapy in Elderly patients with Congestive Heart Failure (TIME-CHF) randomized trial
Huijts M, Brunner-La Rocca H, Pfisterer M, Schindler R, Maeder M, Muzzarelli S, Burkard T, Duits A, van Oostenbrugge R, TIME-CHF Investigators. Cognitive impairment in heart failure: results from the Trial of Intensified versus standard Medical therapy in Elderly patients with Congestive Heart Failure (TIME-CHF) randomized trial. Eur J Heart Fail 2013; 15:699-707.
05.02.2013Cognitive impairment in heart failure: results from the Trial of Intensified versus standard Medical therapy in Elderly patients with Congestive Heart Failure (TIME-CHF) randomized trial
05.02.2013Eur J Heart Fail 2013; 15:699-707
Huijts Marjolein, Brunner-La Rocca Hans-Peter, Pfisterer Matthias E, Schindler Ruth, Maeder Micha, Muzzarelli Stefano, Burkard Thilo, Duits Annelien, van Oostenbrugge Robert J, TIME-CHF Investigators
Cost-effectiveness of N-terminal pro-B-type natriuretic-guided therapy in elderly heart failure patients: results from TIME-CHF (Trial of Intensified versus Standard Medical Therapy in Elderly Patients with Congestive Heart Failure)
Sanders-van Wijk S, Brunner-La Rocca H, Pfisterer M, Peter M, Vuillomenet A, Rickenbacher P, Erne P, Estlinbaum W, Rickli H, van Asselt A, TIME-CHF Investigators. Cost-effectiveness of N-terminal pro-B-type natriuretic-guided therapy in elderly heart failure patients: results from TIME-CHF (Trial of Intensified versus Standard Medical Therapy in Elderly Patients with Congestive Heart Failure). JACC Heart Fail 2013; 1:64-71.
04.02.2013Cost-effectiveness of N-terminal pro-B-type natriuretic-guided therapy in elderly heart failure patients: results from TIME-CHF (Trial of Intensified versus Standard Medical Therapy in Elderly Patients with Congestive Heart Failure)
04.02.2013JACC Heart Fail 2013; 1:64-71
Sanders-van Wijk Sandra, Brunner-La Rocca Hans-Peter, Pfisterer Matthias E, Peter Martin, Vuillomenet André, Rickenbacher Peter, Erne Paul, Estlinbaum Werner, Rickli Hans, van Asselt Antoinette D I, TIME-CHF Investigators
Prognostic value of self-reported versus objectively measured functional capacity in patients with heart failure: results from the TIME-CHF (Trial of Intensified Versus Standard Medical Therapy in Elderly Patients with Congestive Heart Failure)
Spruit M, Brunner-La Rocca H, Rickli H, Pfisterer M, Kiencke S, Uszko-Lencer N, Jeker U, Ammann P, Knackstedt C, Maeder M, TIME-CHF Investigators. Prognostic value of self-reported versus objectively measured functional capacity in patients with heart failure: results from the TIME-CHF (Trial of Intensified Versus Standard Medical Therapy in Elderly Patients with Congestive Heart Failure). J Am Coll Cardiol 2012; 60:2125-6.
13.11.2012Prognostic value of self-reported versus objectively measured functional capacity in patients with heart failure: results from the TIME-CHF (Trial of Intensified Versus Standard Medical Therapy in Elderly Patients with Congestive Heart Failure)
13.11.2012J Am Coll Cardiol 2012; 60:2125-6
Spruit Martijn A, Brunner-La Rocca Hans-Peter, Rickli Hans, Pfisterer Matthias E, Kiencke Stephanie, Uszko-Lencer Nicole H M K, Jeker Urs, Ammann Peter, Knackstedt Christian, Maeder Micha, TIME-CHF Investigators
Incidence, clinical predictors, and prognostic impact of worsening renal function in elderly patients with chronic heart failure on intensive medical therapy
Maeder M, Brunner-La Rocca H, Estlinbaum W, Kiencke S, Dieterle T, Weilenmann D, Hack D, Fehr T, Ammann P, Muzzarelli S, Pfisterer M, Rickli H, TIME-CHF Investigators. Incidence, clinical predictors, and prognostic impact of worsening renal function in elderly patients with chronic heart failure on intensive medical therapy. Am Heart J 2012; 163:407-14, 414.e1.
01.03.2012Incidence, clinical predictors, and prognostic impact of worsening renal function in elderly patients with chronic heart failure on intensive medical therapy
01.03.2012Am Heart J 2012; 163:407-14, 414.e1
Maeder Micha, Brunner-La Rocca Hans-Peter, Estlinbaum Werner, Kiencke Stephanie, Dieterle Thomas, Weilenmann Daniel, Hack Dietrich, Fehr Thomas, Ammann Peter, Muzzarelli Stefano, Pfisterer Matthias E, Rickli Hans, TIME-CHF Investigators
Frequency and predictors of hyperkalemia in patients ≥60 years of age with heart failure undergoing intense medical therapy
Muzzarelli S, Brunner-La Rocca H, Pfisterer M, Burkard T, Julius B, Nietlispach F, Rickli H, Toggweiler S, Maeder M, TIME-CHF Investigators. Frequency and predictors of hyperkalemia in patients ≥60 years of age with heart failure undergoing intense medical therapy. Am J Cardiol 2011; 109:693-8.
05.12.2011Frequency and predictors of hyperkalemia in patients ≥60 years of age with heart failure undergoing intense medical therapy
05.12.2011Am J Cardiol 2011; 109:693-8
Muzzarelli Stefano, Brunner-La Rocca Hans-Peter, Pfisterer Matthias Emil, Burkard Thilo, Julius Barbara, Nietlispach Fabian, Rickli Hans, Toggweiler Stefan, Maeder Micha, TIME-CHF Investigators
End-of-life preferences of elderly patients with chronic heart failure
Brunner-La Rocca H, Rickli H, Pfisterer M, Osswald S, Pfister O, Leventhal M, Kiowski W, Jeker U, Maeder M, Schindler R, Muzzarelli S, Rickenbacher P, TIME-CHF Investigators. End-of-life preferences of elderly patients with chronic heart failure. Eur Heart J 2011; 33:752-9.
08.11.2011End-of-life preferences of elderly patients with chronic heart failure
08.11.2011Eur Heart J 2011; 33:752-9
Brunner-La Rocca Hans-Peter, Rickli Hans, Pfisterer Matthias E, Osswald Stefan, Pfister Otmar, Leventhal Marcia E, Kiowski Wolfgang, Jeker Urs, Maeder Micha, Schindler Ruth, Muzzarelli Stefano, Rickenbacher Peter, TIME-CHF Investigators
Predictors of early readmission or death in elderly patients with heart failure
Muzzarelli S, Brunner-La Rocca H, Pfisterer M, Buser P, Jeker U, Gutmann M, Handschin R, Rickli H, Maeder M, Leibundgut G, TIME-CHF Investigators. Predictors of early readmission or death in elderly patients with heart failure. Am Heart J 2010; 160:308-14.
01.08.2010Predictors of early readmission or death in elderly patients with heart failure
01.08.2010Am Heart J 2010; 160:308-14
Muzzarelli Stefano, Brunner-La Rocca Hans-Peter, Pfisterer Matthias, Buser Peter, Jeker Urs, Gutmann Marc, Handschin Rolf, Rickli Hans, Maeder Micha, Leibundgut Gregor, TIME-CHF Investigators
BNP-guided vs symptom-guided heart failure therapy: the Trial of Intensified vs Standard Medical Therapy in Elderly Patients With Congestive Heart Failure (TIME-CHF) randomized trial
Pfisterer M, Brunner-La Rocca H, Schindler R, Hilti P, Schieber M, Osterhues H, Suter T, Yoon S, Beer H, Dubach P, Jeker U, Vuillomenet A, Rickenbacher P, Erne P, Gutmann M, Rickli H, Buser P, TIME-CHF Investigators. BNP-guided vs symptom-guided heart failure therapy: the Trial of Intensified vs Standard Medical Therapy in Elderly Patients With Congestive Heart Failure (TIME-CHF) randomized trial. JAMA : the journal of the American Medical Association 2009; 301:383-92.
28.01.2009BNP-guided vs symptom-guided heart failure therapy: the Trial of Intensified vs Standard Medical Therapy in Elderly Patients With Congestive Heart Failure (TIME-CHF) randomized trial
28.01.2009JAMA : the journal of the American Medical Association 2009; 301:383-92
Pfisterer Matthias, Brunner-La Rocca Hans-Peter, Schindler Ruth, Hilti Patrick, Schieber Michael M, Osterhues Hans H, Suter Thomas, Yoon Se-Il, Beer Hansjürg, Dubach Paul, Jeker Urs, Vuillomenet André, Rickenbacher Peter, Erne Paul, Gutmann Marc, Rickli Hans, Buser Peter, TIME-CHF Investigators