BNP-guided vs symptom-guided heart failure therapy: the Trial of Intensified vs Standard Medical Therapy in Elderly Patients With Congestive Heart Failure (TIME-CHF) randomized trial

Pfisterer M, Brunner-La Rocca H, Schindler R, Hilti P, Schieber M, Osterhues H, Suter T, Yoon S, Beer H, Dubach P, Jeker U, Vuillomenet A, Rickenbacher P, Erne P, Gutmann M, Rickli H, Buser P, TIME-CHF Investigators. BNP-guided vs symptom-guided heart failure therapy: the Trial of Intensified vs Standard Medical Therapy in Elderly Patients With Congestive Heart Failure (TIME-CHF) randomized trial. JAMA : the journal of the American Medical Association 2009; 301:383-92.