PhD student Hung-Wei Cheng
Institut für Immunbiologie · Dept. Direktion
Fibroblastic reticular cells provide a supportive niche for lymph node-resident macrophages.
D'Rozario J, Knoblich K, Lütge M, Perez Shibayama C, Cheng H, Alexandre Y, Roberts D, Campos J, Dutton E, Suliman M, Denton A, Turley S, Boyd R, Mueller S, Ludewig B, Heng T, Fletcher A. Fibroblastic reticular cells provide a supportive niche for lymph node-resident macrophages. Eur J Immunol 2023; 53:e2250355.
12.07.2023Fibroblastic reticular cells provide a supportive niche for lymph node-resident macrophages.
12.07.2023Eur J Immunol 2023; 53:e2250355
D'Rozario Joshua, Knoblich Konstantin, Lütge Mechthild, Perez Shibayama Christian, Cheng Hung-Wei, Alexandre Yannick O, Roberts David J, Campos Joana, Dutton Emma E, Suliman Muath, Denton Alice E, Turley Shannon J, Boyd Richard L, Mueller Scott N, Ludewig Burkhard, Heng Tracy S P, Fletcher Anne L
Conserved stromal-immune cell circuits secure B cell homeostasis and function.
Lütge M, De Martin A, Gil Cruz C, Perez Shibayama C, Stanossek Y, Onder L, Cheng H, Kurz L, Cadosch N, Soneson C, Robinson M, Stöckli S, Ludewig B, Pikor N. Conserved stromal-immune cell circuits secure B cell homeostasis and function. Nat Immunol 2023
18.05.2023Conserved stromal-immune cell circuits secure B cell homeostasis and function.
18.05.2023Nat Immunol 2023
Lütge Mechthild, De Martin Angelina, Gil Cruz Cristina, Perez Shibayama Christian, Stanossek Yves, Onder Lucas, Cheng Hung-Wei, Kurz Lisa, Cadosch Nadine, Soneson Charlotte, Robinson Mark D, Stöckli Sandro, Ludewig Burkhard, Pikor Natalia
PI16 reticular cells in human palatine tonsils govern T cell activity in distinct subepithelial niches.
De Martin A, Stanossek Y, Lütge M, Cadosch N, Onder L, Cheng H, Brandstadter J, Maillard I, Stöckli S, Pikor N, Ludewig B. PI16 reticular cells in human palatine tonsils govern T cell activity in distinct subepithelial niches. Nat Immunol 2023; 24:1138-1148.
18.05.2023PI16 reticular cells in human palatine tonsils govern T cell activity in distinct subepithelial niches.
18.05.2023Nat Immunol 2023; 24:1138-1148
De Martin Angelina, Stanossek Yves, Lütge Mechthild, Cadosch Nadine, Onder Lucas, Cheng Hung-Wei, Brandstadter Joshua D, Maillard Ivan, Stöckli Sandro, Pikor Natalia, Ludewig Burkhard
An Innate Checkpoint Determines Immune Dysregulation and Immunopathology during Pulmonary Murine Coronavirus Infection.
Grabherr S, Waltenspühl A, Büchler L, Lütge M, Cheng H, Caviezel-Firner S, Ludewig B, Krebs P, Pikor N. An Innate Checkpoint Determines Immune Dysregulation and Immunopathology during Pulmonary Murine Coronavirus Infection. J Immunol 2023; 210:774-785.
15.03.2023An Innate Checkpoint Determines Immune Dysregulation and Immunopathology during Pulmonary Murine Coronavirus Infection.
15.03.2023J Immunol 2023; 210:774-785
Grabherr Sarah, Waltenspühl Alexandra, Büchler Lorina, Lütge Mechthild, Cheng Hung-Wei, Caviezel-Firner Sonja, Ludewig Burkhard, Krebs Philippe, Pikor Natalia
Autoreactive napsin A-specific T cells are enriched in lung tumors and inflammatory lung lesions during immune checkpoint blockade.
Berner F, Bomze D, Lichtensteiger C, Walter V, Niederer R, Hasan Ali O, Wyss N, Bauer J, Freudenmann L, Marcu A, Wolfschmitt E, Haen S, Gross T, Abdou M, Diem S, Knöpfli S, Sinnberg T, Hofmeister K, Cheng H, Toma M, Klümper N, Purde M, Pop O, Jochum A, Pascolo S, Jörger M, Früh M, Jochum W, Rammensee H, Läubli H, Hölzel M, Neefjes J, Walz J, Flatz L. Autoreactive napsin A-specific T cells are enriched in lung tumors and inflammatory lung lesions during immune checkpoint blockade. Sci Immunol 2022; 7:eabn9644.
02.09.2022Autoreactive napsin A-specific T cells are enriched in lung tumors and inflammatory lung lesions during immune checkpoint blockade.
02.09.2022Sci Immunol 2022; 7:eabn9644
Berner Fiamma, Bomze David, Lichtensteiger Christa, Walter Vincent, Niederer Rebekka, Hasan Ali Omar, Wyss Nina, Bauer Jens, Freudenmann Lena Katharina, Marcu Ana, Wolfschmitt Eva-Maria, Haen Sebastian, Gross Thorben, Abdou Marie-Therese, Diem Stefan, Knöpfli Stella, Sinnberg Tobias, Hofmeister Kathrin, Cheng Hung-Wei, Toma Marieta, Klümper Niklas, Purde Mette-Triin, Pop Oltin Tiberiu, Jochum Ann-Kristin, Pascolo Steve, Jörger Markus, Früh Martin, Jochum Wolfram, Rammensee Hans-Georg, Läubli Heinz, Hölzel Michael, Neefjes Jacques, Walz Juliane, Flatz Lukas
Intestinal fibroblastic reticular cell niches control innate lymphoid cell homeostasis and function
Cheng H, Scandella E, Hehlgans T, Perez Shibayama C, Gil Cruz C, Novkovic M, Onder L, Engetschwiler C, Lütge M, Mörbe U, Ludewig B. Intestinal fibroblastic reticular cell niches control innate lymphoid cell homeostasis and function. Nat Commun 2022; 13:2027.
19.04.2022Intestinal fibroblastic reticular cell niches control innate lymphoid cell homeostasis and function
19.04.2022Nat Commun 2022; 13:2027
Cheng Hung-Wei, Scandella Elke, Hehlgans T, Perez Shibayama Christian, Gil Cruz Cristina, Novkovic M, Onder Lucas, Engetschwiler Céline, Lütge Mechthild, Mörbe Urs, Ludewig Burkhard
Visualization and functional characterization of lymphoid organ fibroblasts
Onder L, Cheng H, Ludewig B. Visualization and functional characterization of lymphoid organ fibroblasts. Immunol Rev 2021
05.12.2021Visualization and functional characterization of lymphoid organ fibroblasts
05.12.2021Immunol Rev 2021
Onder Lucas, Cheng Hung-Wei, Ludewig Burkhard
Adenovirus vector vaccination reprograms pulmonary fibroblastic niches to support protective inflating memory CD8 T cells
Cupovic J, Klenerman P, Engeler D, Krebs P, Scandella E, Oxenius A, Flatz L, Provine N, De Martin A, Cheng H, Lütge M, Colston J, Onder L, Ring S, Ludewig B. Adenovirus vector vaccination reprograms pulmonary fibroblastic niches to support protective inflating memory CD8 T cells. Nat Immunol 2021; 22:1042-1051.
15.07.2021Adenovirus vector vaccination reprograms pulmonary fibroblastic niches to support protective inflating memory CD8 T cells
15.07.2021Nat Immunol 2021; 22:1042-1051
Cupovic Jovana, Klenerman Paul, Engeler Daniel, Krebs Philippe, Scandella Elke, Oxenius Annette, Flatz Lukas, Provine Nicholas M, De Martin Angelina, Cheng Hung-Wei, Lütge Mechthild, Colston Julia M, Onder Lucas, Ring Sandra, Ludewig Burkhard
Fibroblastic reticular cell lineage convergence in Peyer's patches governs intestinal immunity
Prados A, Ludewig B, Koliaraki V, Perez Shibayama C, Gil Cruz C, Lütge M, Mörbe U, Cheng H, Onder L, Kollias G. Fibroblastic reticular cell lineage convergence in Peyer's patches governs intestinal immunity. Nat Immunol 2021; 22:510-519.
11.03.2021Fibroblastic reticular cell lineage convergence in Peyer's patches governs intestinal immunity
11.03.2021Nat Immunol 2021; 22:510-519
Prados Alejandro, Ludewig Burkhard, Koliaraki Vasiliki, Perez Shibayama Christian, Gil Cruz Cristina, Lütge Mechthild, Mörbe Urs, Cheng Hung-Wei, Onder Lucas, Kollias George
Development and Immunological Function of Lymph Node Stromal Cells
Pikor N, Cheng H, Onder L, Ludewig B. Development and Immunological Function of Lymph Node Stromal Cells. J Immunol 2021; 206:257-263.
15.01.2021Development and Immunological Function of Lymph Node Stromal Cells
15.01.2021J Immunol 2021; 206:257-263
Pikor Natalia, Cheng Hung-Wei, Onder Lucas, Ludewig Burkhard
Group 3 Innate Lymphoid Cells Program a Distinct Subset of IL-22BP-Producing Dendritic Cells Demarcating Solitary Intestinal Lymphoid Tissues
Guendel F, Hehlgans T, Waisman A, Becher B, Giannou A, Brachs S, Ebert K, Tanriver Y, Ludewig B, Mashreghi M, Kruglov A, Pfeffer K, Herold S, Ruedl C, Kofoed-Branzk M, Gronke K, Tizian C, Witkowski M, Cheng H, Heinz G, Heinrich F, Durek P, Norris P, Ware C, Diefenbach A. Group 3 Innate Lymphoid Cells Program a Distinct Subset of IL-22BP-Producing Dendritic Cells Demarcating Solitary Intestinal Lymphoid Tissues. Immunity 2020; 53:1015-1032.e8.
17.11.2020Group 3 Innate Lymphoid Cells Program a Distinct Subset of IL-22BP-Producing Dendritic Cells Demarcating Solitary Intestinal Lymphoid Tissues
17.11.2020Immunity 2020; 53:1015-1032.e8
Guendel Fabian, Hehlgans Thomas, Waisman Ari, Becher Burkhard, Giannou Anastasios D, Brachs Sebastian, Ebert Karolina, Tanriver Yakup, Ludewig Burkhard, Mashreghi Mir-Farzin, Kruglov Andrey A, Pfeffer Klaus, Herold Susanne, Ruedl Christiane, Kofoed-Branzk Michael, Gronke Konrad, Tizian Caroline, Witkowski Mario, Cheng Hung-Wei, Heinz Gitta Anne, Heinrich Frederik, Durek Pawel, Norris Paula S, Ware Carl F, Diefenbach Andreas
Type I interferon signaling in fibroblastic reticular cells prevents exhaustive activation of antiviral CD8 T cells
Perez Shibayama C, Gil Cruz C, Colston J, Novkovic M, De Martin A, Ring S, Onder L, Cheng H, Lütge M, Islander U, Ludewig B. Type I interferon signaling in fibroblastic reticular cells prevents exhaustive activation of antiviral CD8 T cells. Sci Immunol 2020; 5
11.09.2020Type I interferon signaling in fibroblastic reticular cells prevents exhaustive activation of antiviral CD8 T cells
11.09.2020Sci Immunol 2020; 5
Perez Shibayama Christian, Gil Cruz Cristina, Colston Julia, Novkovic Mario, De Martin Angelina, Ring Sandra, Onder Lucas, Cheng Hung-Wei, Lütge Mechthild, Islander Ulrika, Ludewig Burkhard
Remodeling of light and dark zone follicular dendritic cells governs germinal center responses
Pikor N, Onder L, Linterman M, Nagasawa T, Nombela-Arrieta C, Cheng H, Novkovic M, Perez Shibayama C, Gil Cruz C, Lütge M, Mörbe U, Ludewig B. Remodeling of light and dark zone follicular dendritic cells governs germinal center responses. Nat Immunol 2020; 21:649-659.
18.05.2020Remodeling of light and dark zone follicular dendritic cells governs germinal center responses
18.05.2020Nat Immunol 2020; 21:649-659
Pikor Natalia, Onder Lucas, Linterman Michelle A, Nagasawa Takashi, Nombela-Arrieta César, Cheng Hung-Wei, Novkovic Mario, Perez Shibayama Christian, Gil Cruz Cristina, Lütge Mechthild, Mörbe Urs, Ludewig Burkhard
Visualization of T Cell Migration in the Spleen Reveals a Network of Perivascular Pathways that Guide Entry into T Zones
Chauveau A, Pirgova G, Cheng H, De Martin A, Zhou F, Wideman S, Rittscher J, Ludewig B, Arnon T. Visualization of T Cell Migration in the Spleen Reveals a Network of Perivascular Pathways that Guide Entry into T Zones. Immunity 2020
09.04.2020Visualization of T Cell Migration in the Spleen Reveals a Network of Perivascular Pathways that Guide Entry into T Zones
09.04.2020Immunity 2020
Chauveau Anne, Pirgova Gabriela, Cheng Hung-Wei, De Martin Angelina, Zhou Felix Y, Wideman Sarah, Rittscher Jens, Ludewig Burkhard, Arnon Tal I
Association of Checkpoint Inhibitor-Induced Toxic Effects With Shared Cancer and Tissue Antigens in Non-Small Cell Lung Cancer
Berner F, Hartmann F, Cheng H, Hönger G, Recher M, Goldman J, Cozzio A, Früh M, Neefjes J, Driessen C, Ludewig B, Hegazy A, Jochum W, Speiser D, Zippelius A, Läubli H, Bomze D, Diem S, Ali O, Fässler M, Ring S, Niederer R, Ackermann C, Baumgaertner P, Pikor N, Cruz C, van de Veen W, Akdis M, Nikolaev S, Flatz L. Association of Checkpoint Inhibitor-Induced Toxic Effects With Shared Cancer and Tissue Antigens in Non-Small Cell Lung Cancer. JAMA Oncol 2019; 5:1043-1047.
01.07.2019Association of Checkpoint Inhibitor-Induced Toxic Effects With Shared Cancer and Tissue Antigens in Non-Small Cell Lung Cancer
01.07.2019JAMA Oncol 2019; 5:1043-1047
Berner Fiamma, Hartmann Fabienne, Cheng Hung-Wei, Hönger Gideon, Recher Mike, Goldman Jonathan, Cozzio Antonio, Früh Martin, Neefjes Jacques, Driessen Christoph, Ludewig Burkhard, Hegazy Ahmed N, Jochum Wolfram, Speiser Daniel E, Zippelius Alfred, Läubli Heinz, Bomze David, Diem Stefan, Ali Omar Hasan, Fässler Mirjam, Ring Sandra, Niederer Rebekka, Ackermann Christoph J, Baumgaertner Petra, Pikor Natalia, Cruz Cristina Gil, van de Veen Willem, Akdis Mübeccel, Nikolaev Sergey, Flatz Lukas
Origin and differentiation trajectories of fibroblastic reticular cells in the splenic white pulp
Cheng H, Hehlgans T, Rülicke T, Pfeffer K, Sorg U, Tersteegen A, Miyazaki J, Robinson M, Scandella E, Pikor N, Lütge M, Soneson C, Novkovic M, Onder L, Ludewig B. Origin and differentiation trajectories of fibroblastic reticular cells in the splenic white pulp. Nat Commun 2019; 10:1739.
15.04.2019Origin and differentiation trajectories of fibroblastic reticular cells in the splenic white pulp
15.04.2019Nat Commun 2019; 10:1739
Cheng Hung-Wei, Hehlgans Thomas, Rülicke Thomas, Pfeffer Klaus, Sorg Ursula, Tersteegen Anne, Miyazaki Jun-Ichi, Robinson Mark D, Scandella Elke, Pikor Natalia, Lütge Mechthild, Soneson Charlotte, Novkovic Mario, Onder Lucas, Ludewig Burkhard
Integrative Computational Modeling of the Lymph Node Stromal Cell Landscape
Novkovic M, Onder L, Cheng H, Bocharov G, Ludewig B. Integrative Computational Modeling of the Lymph Node Stromal Cell Landscape. Front Immunol 2018; 9:2428.
23.10.2018Integrative Computational Modeling of the Lymph Node Stromal Cell Landscape
23.10.2018Front Immunol 2018; 9:2428
Novkovic Mario, Onder Lucas, Cheng Hung-Wei, Bocharov Gennady, Ludewig Burkhard
Fibroblastic reticular cells initiate immune responses in visceral adipose tissues and secure peritoneal immunity
Perez Shibayama C, Gommerman J, Scandella E, Robinson M, Soneson C, Mack M, Turley S, Buechler M, López-Macías C, Li C, Novkovic M, Mörbe U, Printz A, Onder L, Cheng H, Gil Cruz C, Ludewig B. Fibroblastic reticular cells initiate immune responses in visceral adipose tissues and secure peritoneal immunity. Sci Immunol 2018; 3
10.08.2018Fibroblastic reticular cells initiate immune responses in visceral adipose tissues and secure peritoneal immunity
10.08.2018Sci Immunol 2018; 3
Perez Shibayama Christian, Gommerman Jennifer, Scandella Elke, Robinson Mark D, Soneson Charlotte, Mack Matthias, Turley Shannon J, Buechler Matthew B, López-Macías Constantino, Li Conglei, Novkovic Mario, Mörbe Urs, Printz Andrea, Onder Lucas, Cheng Hung-Wei, Gil Cruz Cristina, Ludewig Burkhard
CCL19-producing fibroblastic stromal cells restrain lung carcinoma growth by promoting local antitumor T-cell responses
Cheng H, Brutsche M, Jochum W, Schneider T, Rodriguez R, Tarantino I, Pikor N, Novkovic M, Bösch M, Cupovic J, Onder L, Ludewig B. CCL19-producing fibroblastic stromal cells restrain lung carcinoma growth by promoting local antitumor T-cell responses. J Allergy Clin Immunol 2018
31.01.2018CCL19-producing fibroblastic stromal cells restrain lung carcinoma growth by promoting local antitumor T-cell responses
31.01.2018J Allergy Clin Immunol 2018
Cheng Hung-Wei, Brutsche Martin, Jochum Wolfram, Schneider Tino, Rodriguez Regulo, Tarantino Ignazio, Pikor Natalia, Novkovic Mario, Bösch Maximilian, Cupovic Jovana, Onder Lucas, Ludewig Burkhard
Oxysterol Sensing through the Receptor GPR183 Promotes the Lymphoid-Tissue-Inducing Function of Innate Lymphoid Cells and Colonic Inflammation
Emgård J, Svensson M, Scandella E, Hepworth M, Huber S, Ludewig B, Peduto L, Villablanca E, Veiga-Fernandes H, Pereira J, Flavell R, Kvedaraite E, Melo-Gonzalez F, Kammoun H, García-Cassani B, Chesné J, Parigi S, Jacob J, Cheng H, Evren E, Das S, Czarnewski P, Sleiers N, Willinger T. Oxysterol Sensing through the Receptor GPR183 Promotes the Lymphoid-Tissue-Inducing Function of Innate Lymphoid Cells and Colonic Inflammation. Immunity 2018; 48:120-132.e8.
16.01.2018Oxysterol Sensing through the Receptor GPR183 Promotes the Lymphoid-Tissue-Inducing Function of Innate Lymphoid Cells and Colonic Inflammation
16.01.2018Immunity 2018; 48:120-132.e8
Emgård Johanna, Svensson Mattias, Scandella Elke, Hepworth Matthew R, Huber Samuel, Ludewig Burkhard, Peduto Lucie, Villablanca Eduardo J, Veiga-Fernandes Henrique, Pereira João P, Flavell Richard A, Kvedaraite Egle, Melo-Gonzalez Felipe, Kammoun Hana, García-Cassani Bethania, Chesné Julie, Parigi Sara M, Jacob Jean-Marie, Cheng Hung-Wei, Evren Elza, Das Srustidhar, Czarnewski Paulo, Sleiers Natalie, Willinger Tim