René Günther
Safety, tolerability, and efficacy of fasudil in amyotrophic lateral sclerosis (ROCK-ALS): a phase 2, randomised, double-blind, placebo-controlled trial.
Koch J, Leha A, Bidner H, Cordts I, Dorst J, Günther R, Zeller D, Braun N, Metelmann M, Corcia P, Depla E, Weydt P, Meyer T, Grosskreutz J, Soriani M, Attarian S, Weishaupt J, Weyen U, Kuttler J, Zurek G, Rogers M, Feneberg E, Deschauer M, Neuwirth C, Wuu J, Ludolph A, Schmidt J, Remane Y, Camu W, Friede T, Benatar M, Weber M, Lingor P, ROCK-ALS Study group. Safety, tolerability, and efficacy of fasudil in amyotrophic lateral sclerosis (ROCK-ALS): a phase 2, randomised, double-blind, placebo-controlled trial. Lancet Neurol 2024; 23:1133-1146.
01.11.2024Safety, tolerability, and efficacy of fasudil in amyotrophic lateral sclerosis (ROCK-ALS): a phase 2, randomised, double-blind, placebo-controlled trial.
01.11.2024Lancet Neurol 2024; 23:1133-1146
Koch Jan Christoph, Leha Andreas, Bidner Helen, Cordts Isabell, Dorst Johannes, Günther René, Zeller Daniel, Braun Nathalie, Metelmann Moritz, Corcia Philippe, Depla Erik, Weydt Patrick, Meyer Thomas, Grosskreutz Julian, Soriani Marie-Hélène, Attarian Shahram, Weishaupt Jochen H, Weyen Ute, Kuttler Josua, Zurek Gabriela, Rogers Mary-Louise, Feneberg Emily, Deschauer Marcus, Neuwirth Christoph, Wuu Joanne, Ludolph Albert C., Schmidt Jens, Remane Yvonne, Camu William, Friede Tim, Benatar Michael, Weber Markus, Lingor Paul, ROCK-ALS Study group
5qSMA: standardised retrospective natural history assessment in 268 patients with four copies of SMN2.
Vill K, Tacke M, König A, Baumann M, Baumgartner M, Steinbach M, Bernert G, Blaschek A, Deschauer M, Flotats-Bastardas M, Friese J, Goldbach S, Gross M, Günther R, Hahn A, Hagenacker T, Hauser E, Horber V, Illsinger S, Johannsen J, Kamm C, Koch J, Kölbel H, Köhler C, Kolzter K, Lochmüller H, Ludolph A, Mensch A, Meyer Zu Hoerste G, Mueller M, Mueller-Felber W, Neuwirth C, Petri S, Probst-Schendzielorz K, Pühringer M, Steinbach R, Schara-Schmidt U, Schimmel M, Schrank B, Schwartz O, Schlachter K, Schwerin-Nagel A, Schreiber G, Smitka M, Topakian R, Trollmann R, Türk M, Theophil M, Rauscher C, Vorgerd M, Walter M, Weiler M, Weiss C, Wilichowski E, Wurster C, Wunderlich G, Zeller D, Ziegler A, Kirschner J, Pechmann A, SMArtCARE study group. 5qSMA: standardised retrospective natural history assessment in 268 patients with four copies of SMN2. J Neurol 2024
27.02.20245qSMA: standardised retrospective natural history assessment in 268 patients with four copies of SMN2.
27.02.2024J Neurol 2024
Vill Katharina, Tacke Moritz, König Anna, Baumann Matthias, Baumgartner Manuela, Steinbach Meike, Bernert Günther, Blaschek Astrid, Deschauer Marcus, Flotats-Bastardas Marina, Friese Johannes, Goldbach Susanne, Gross Martin, Günther René, Hahn Andreas, Hagenacker Tim, Hauser Erwin, Horber Veronka, Illsinger Sabine, Johannsen Jessika, Kamm Christoph, Koch Jan Christoph, Kölbel Heike, Köhler Cornelia, Kolzter Kirsten, Lochmüller Hanns, Ludolph Albert C, Mensch Alexander, Meyer Zu Hoerste Gerd, Mueller Monika, Mueller-Felber Wolfgang, Neuwirth Christoph, Petri Susanne, Probst-Schendzielorz Kristina, Pühringer Manuel, Steinbach Robert, Schara-Schmidt Ulrike, Schimmel Mareike, Schrank Bertold, Schwartz Oliver, Schlachter Kurt, Schwerin-Nagel Annette, Schreiber Gudrun, Smitka Martin, Topakian Raffi, Trollmann Regina, Türk Matthias, Theophil Manuela, Rauscher Christian, Vorgerd Mathias, Walter M C, Weiler Markus, Weiss Claudia, Wilichowski Ekkehard, Wurster Claudia D, Wunderlich Gilbert, Zeller Daniel, Ziegler Andreas, Kirschner Janbernd, Pechmann Astrid, SMArtCARE study group
Long-term efficacy and safety of nusinersen in adults with 5q spinal muscular atrophy: a prospective European multinational observational study.
Günther R, Wurster C, Brakemeier S, Osmanovic A, Schreiber-Katz O, Petri S, Uzelac Z, Hiebeler M, Thiele S, Walter M, Weiler M, Kessler T, Freigang M, Lapp H, Cordts I, Lingor P, Deschauer M, Hahn A, Martakis K, Steinbach R, Ilse B, Roediger A, Bellut J, Nentwich J, Zeller D, Muhandes M, Baum T, Koch J, Schrank B, Fischer S, Hermann A, Kamm C, Naegel S, Mensch A, Weber M, Neuwirth C, Lehmann H, Wunderlich G, Stadler C, Tomforde M, George A, Gross M, Pechmann A, Kirschner J, Türk M, Schimmel M, Bernert G, Martin P, Rauscher C, Meyer Zu Hörste G, Baum P, Löscher W, Flotats-Bastardas M, Köhler C, Probst-Schendzielorz K, Goldbach S, Schara-Schmidt U, Mueller-Felber W, Lochmüller H, von Velsen O, SMArtCARE study group, Kleinschnitz C, Ludolph A, Hagenacker T. Long-term efficacy and safety of nusinersen in adults with 5q spinal muscular atrophy: a prospective European multinational observational study. Lancet Reg Health Eur 2024; 39:100862.
06.02.2024Long-term efficacy and safety of nusinersen in adults with 5q spinal muscular atrophy: a prospective European multinational observational study.
06.02.2024Lancet Reg Health Eur 2024; 39:100862
Günther René, Wurster Claudia Diana, Brakemeier Svenja, Osmanovic Alma, Schreiber-Katz Olivia, Petri Susanne, Uzelac Zeljko, Hiebeler Miriam, Thiele Simone, Walter M C, Weiler Markus, Kessler Tobias, Freigang Maren, Lapp Hanna Sophie, Cordts Isabell, Lingor Paul, Deschauer Marcus, Hahn Andreas, Martakis Kyriakos, Steinbach Robert, Ilse Benjamin, Roediger Annekathrin, Bellut Julia, Nentwich Julia, Zeller Daniel, Muhandes Mohamad Tareq, Baum Tobias, Koch Jan Christoph, Schrank Bertold, Fischer Sophie, Hermann Andreas, Kamm Christoph, Naegel Steffen, Mensch Alexander, Weber Markus, Neuwirth Christoph, Lehmann Helmar C, Wunderlich Gilbert, Stadler Christian, Tomforde Maike, George Annette, Gross Martin, Pechmann Astrid, Kirschner Janbernd, Türk Matthias, Schimmel Mareike, Bernert Günther, Martin Pascal, Rauscher Christian, Meyer Zu Hörste Gerd, Baum Petra, Löscher Wolfgang, Flotats-Bastardas Marina, Köhler Cornelia, Probst-Schendzielorz Kristina, Goldbach Susanne, Schara-Schmidt Ulrike, Mueller-Felber Wolfgang, Lochmüller Hanns, von Velsen Otgonzul, SMArtCARE study group, Kleinschnitz Christoph, Ludolph Albert C, Hagenacker Tim
Improvements in Walking Distance during Nusinersen Treatment - A Prospective 3-year SMArtCARE Registry Study.
Pechmann A, Behrens M, Dörnbrack K, Tassoni A, Wenzel F, Stein S, Vogt S, Zöller D, Bernert G, Hagenacker T, Schara-Schmidt U, Walter M, Steinbach M, Blaschek A, Baumann M, Baumgartner M, Becker B, Flotats-Bastardas M, Friese J, Günther R, Hahn A, Küpper H, Johannsen J, Kamm C, Koch J, Köhler C, Kölbel H, Kolzter K, von Moers A, Naegel S, Neuwirth C, Petri S, Roediger A, Schimmel M, Schrank B, Schreiber G, Smitka M, Stadler C, Steiner E, Stögmann E, Trollmann R, Türk M, Weiler M, Stoltenburg C, Willichowsky E, Zeller D, Ziegler A, Lochmüller H, Kirschner J, SMArtCARE study group. Improvements in Walking Distance during Nusinersen Treatment - A Prospective 3-year SMArtCARE Registry Study. J Neuromuscul Dis 2023; 10:29-40.
01.01.2023Improvements in Walking Distance during Nusinersen Treatment - A Prospective 3-year SMArtCARE Registry Study.
01.01.2023J Neuromuscul Dis 2023; 10:29-40
Pechmann Astrid, Behrens Max, Dörnbrack Katharina, Tassoni Adrian, Wenzel Franziska, Stein Sabine, Vogt Sibylle, Zöller Daniela, Bernert Günther, Hagenacker Tim, Schara-Schmidt Ulrike, Walter M C, Steinbach Meike, Blaschek Astrid, Baumann Matthias, Baumgartner Manuela, Becker Benedikt, Flotats-Bastardas Marina, Friese Johannes, Günther René, Hahn Andreas, Küpper Hanna, Johannsen Jessika, Kamm Christoph, Koch Jan Christoph, Köhler Cornelia, Kölbel Heike, Kolzter Kirsten, von Moers Arpad, Naegel Steffen, Neuwirth Christoph, Petri Susanne, Roediger Annekathrin, Schimmel Mareike, Schrank Bertold, Schreiber Gudrun, Smitka Martin, Stadler Christian, Steiner Elisabeth, Stögmann Eva, Trollmann Regina, Türk Matthias, Weiler Markus, Stoltenburg Corinna, Willichowsky Ekkehard, Zeller Daniel, Ziegler Andreas, Lochmüller Hanns, Kirschner Janbernd, SMArtCARE study group
Challenges and opportunities for Multi-National Investigator-Initiated clinical trials for ALS: European and United States collaborations
Lingor P, Tostmann R, Neuwirth C, Meyer T, Lengenfeld T, Leha A, Kuttler J, Kollewe K, Kassubek J, Ilse B, Günther R, Ahmed R, Langbein T, Wuu J, Hennecke C, Hussain S, Statland J, Koch J, Benatar M. Challenges and opportunities for Multi-National Investigator-Initiated clinical trials for ALS: European and United States collaborations. Amyotroph Lateral Scler Frontotemporal Degener 2021; 22:419-425.
03.02.2021Challenges and opportunities for Multi-National Investigator-Initiated clinical trials for ALS: European and United States collaborations
03.02.2021Amyotroph Lateral Scler Frontotemporal Degener 2021; 22:419-425
Lingor Paul, Tostmann Ralf, Neuwirth Christoph, Meyer Thomas, Lengenfeld Teresa, Leha Andreas, Kuttler Josua, Kollewe Katja, Kassubek Jan, Ilse Benjamin, Günther René, Ahmed Raees, Langbein Thomas, Wuu Joanne, Hennecke Christiane, Hussain Sumaira, Statland Jeffrey M, Koch Jan C, Benatar Michael
ROCK-ALS: Protocol for a Randomized, Placebo-Controlled, Double-Blind Phase IIa Trial of Safety, Tolerability and Efficacy of the Rho Kinase (ROCK) Inhibitor Fasudil in Amyotrophic Lateral Sclerosis
Lingor P, Koch J, Ludolph A, Frontini R, Blankenstein C, Bidner H, Kuzma-Kozakiewicz M, Benatar M, Günther R, Neuwirth C, Leha A, Hilgers R, Friede T, Camu W, Weber M, ROCK-ALS Investigators. ROCK-ALS: Protocol for a Randomized, Placebo-Controlled, Double-Blind Phase IIa Trial of Safety, Tolerability and Efficacy of the Rho Kinase (ROCK) Inhibitor Fasudil in Amyotrophic Lateral Sclerosis. Front Neurol 2019; 10:293.
27.03.2019ROCK-ALS: Protocol for a Randomized, Placebo-Controlled, Double-Blind Phase IIa Trial of Safety, Tolerability and Efficacy of the Rho Kinase (ROCK) Inhibitor Fasudil in Amyotrophic Lateral Sclerosis
27.03.2019Front Neurol 2019; 10:293
Lingor Paul, Koch Jan C, Ludolph Albert, Frontini Roberto, Blankenstein Christiane, Bidner Helen, Kuzma-Kozakiewicz Magdalena, Benatar Michael, Günther René, Neuwirth Christoph, Leha Andreas, Hilgers Reinhard, Friede Tim, Camu William, Weber Markus, ROCK-ALS Investigators
Motor Unit Number Index (MUNIX) of hand muscles is a disease biomarker for adult spinal muscular atrophy
Günther R, Neuwirth C, Koch J, Lingor P, Braun N, Untucht R, Petzold D, Weber M, Hermann A. Motor Unit Number Index (MUNIX) of hand muscles is a disease biomarker for adult spinal muscular atrophy. Clin Neurophysiol 2018
24.11.2018Motor Unit Number Index (MUNIX) of hand muscles is a disease biomarker for adult spinal muscular atrophy
24.11.2018Clin Neurophysiol 2018
Günther René, Neuwirth Christoph, Koch Jan Christoph, Lingor Paul, Braun Nathalie, Untucht Robert, Petzold Daniel, Weber Markus, Hermann Andreas