Herman S Overkleeft
High Immunoproteasome Activity and sXBP1 in Pediatric Precursor B-ALL Predicts Sensitivity towards Proteasome Inhibitors
Besse L, Besse A, Kraus M, Maurits E, Overkleeft H, Bornhauser B, Bourquin J, Driessen C. High Immunoproteasome Activity and sXBP1 in Pediatric Precursor B-ALL Predicts Sensitivity towards Proteasome Inhibitors. Cells 2021; 10
22.10.2021High Immunoproteasome Activity and sXBP1 in Pediatric Precursor B-ALL Predicts Sensitivity towards Proteasome Inhibitors
22.10.2021Cells 2021; 10
Besse Lenka, Besse Andrej, Kraus Marianne, Maurits Elmer, Overkleeft Herman S, Bornhauser Beat, Bourquin Jean-Pierre, Driessen Christoph
Treatment with HIV-Protease Inhibitor Nelfinavir Identifies Membrane Lipid Composition and Fluidity as a Therapeutic Target in Advanced Multiple Myeloma
Besse L, Pilon M, Farhan H, Vulpe C, Overkleeft H, Driessen C, Ståhlman M, Huber J, Bolomsky A, Ludwig H, Hannich J, Loguinov A, Everts B, Berkers C, Besse A, Borén J, Florea B, Sathianathan M, Stolze S, Sobh A, Zaal E, van der Ham A, Ruiz M, Phuyal S, Büchler L. Treatment with HIV-Protease Inhibitor Nelfinavir Identifies Membrane Lipid Composition and Fluidity as a Therapeutic Target in Advanced Multiple Myeloma. Cancer Res 2021; 81:4581-4593.
22.06.2021Treatment with HIV-Protease Inhibitor Nelfinavir Identifies Membrane Lipid Composition and Fluidity as a Therapeutic Target in Advanced Multiple Myeloma
22.06.2021Cancer Res 2021; 81:4581-4593
Besse Lenka, Pilon Marc, Farhan Hesso, Vulpe Christopher D, Overkleeft Herman S, Driessen Christoph, Ståhlman Marcus, Huber Julia, Bolomsky Arnold, Ludwig Heinz, Hannich J Thomas, Loguinov Alex, Everts Bart, Berkers Celia R, Besse Andrej, Borén Jan, Florea Bogdan I, Sathianathan Marc, Stolze Sara C, Sobh Amin, Zaal Esther A, van der Ham Alwin J, Ruiz Mario, Phuyal Santosh, Büchler Lorina
Structure-Based Design of Inhibitors Selective for Human Proteasome β2c or β2i Subunits
Xin B, Groll M, van der Marel G, Driessen C, Florea B, Kisselev A, Weyburne E, Janssens M, Du Y, Espinal C, Maurits E, Heinemeyer W, de Bruin G, Huber E, Overkleeft H. Structure-Based Design of Inhibitors Selective for Human Proteasome β2c or β2i Subunits. J Med Chem 2019; 62:1626-1642.
05.02.2019Structure-Based Design of Inhibitors Selective for Human Proteasome β2c or β2i Subunits
05.02.2019J Med Chem 2019; 62:1626-1642
Xin Bo-Tao, Groll Michael, van der Marel Gijsbert A, Driessen Christoph, Florea Bogdan I, Kisselev Alexei F, Weyburne Emily S, Janssens Marissa, Du Yimeng, Espinal Christofer, Maurits Elmer, Heinemeyer Wolfgang, de Bruin Gerjan, Huber Eva M, Overkleeft Herman S
An inhibitor of proteasome β2 sites sensitizes myeloma cells to immunoproteasome inhibitors
Downey-Kopyscinski S, Overkleeft H, Driessen C, Richardson P, Mitsiades C, Florea B, Bhatt A, Gautier M, Daily E, Kisselev A. An inhibitor of proteasome β2 sites sensitizes myeloma cells to immunoproteasome inhibitors. Blood Adv 2018; 2:2443-2451.
09.10.2018An inhibitor of proteasome β2 sites sensitizes myeloma cells to immunoproteasome inhibitors
09.10.2018Blood Adv 2018; 2:2443-2451
Downey-Kopyscinski Sondra, Overkleeft Herman S, Driessen Christoph, Richardson Paul G, Mitsiades Constantine S, Florea Bogdan I, Bhatt Ananta, Gautier Marc, Daily Ellen W, Kisselev Alexei F
Structure-Based Design of β5c Selective Inhibitors of Human Constitutive Proteasomes
Xin B, Groll M, Driessen C, van der Stelt M, Kisselev A, van der Marel G, Filippov D, Florea B, Besse A, Huber E, de Bruin G, Overkleeft H. Structure-Based Design of β5c Selective Inhibitors of Human Constitutive Proteasomes. J Med Chem 2016; 59:7177-87.
01.08.2016Structure-Based Design of β5c Selective Inhibitors of Human Constitutive Proteasomes
01.08.2016J Med Chem 2016; 59:7177-87
Xin Bo-Tao, Groll Michael, Driessen Christoph, van der Stelt Mario, Kisselev Alexei F, van der Marel Gijsbert A, Filippov Dmitri V, Florea Bogdan I, Besse Andrej, Huber Eva M, de Bruin Gerjan, Overkleeft Herman S
Development of new Malt1 inhibitors and probes
Xin B, Schimmack G, Du Y, Florea B, van der Marel G, Driessen C, Krappmann D, Overkleeft H. Development of new Malt1 inhibitors and probes. Bioorg Med Chem 2016; 24:3312-29.
28.03.2016Development of new Malt1 inhibitors and probes
28.03.2016Bioorg Med Chem 2016; 24:3312-29
Xin Bo-Tao, Schimmack Gisela, Du Yimeng, Florea Bogdan I, van der Marel Gijsbert A, Driessen Christoph, Krappmann Daniel, Overkleeft Herman S
A Set of Activity-Based Probes to Visualize Human (Immuno)proteasome Activities
de Bruin G, Xin B, Kraus M, van der Stelt M, van der Marel G, Kisselev A, Driessen C, Florea B, Overkleeft H. A Set of Activity-Based Probes to Visualize Human (Immuno)proteasome Activities. Angew Chem Int Ed Engl 2015; 55:4199-203.
29.10.2015A Set of Activity-Based Probes to Visualize Human (Immuno)proteasome Activities
29.10.2015Angew Chem Int Ed Engl 2015; 55:4199-203
de Bruin Gerjan, Xin Bo Tao, Kraus Marianne, van der Stelt Mario, van der Marel Gijsbert A, Kisselev Alexei F, Driessen Christoph, Florea Bogdan I, Overkleeft Herman S
Structure-based design of β1i or β5i specific inhibitors of human immunoproteasomes
de Bruin G, Groll M, van der Marel G, van der Stelt M, Driessen C, Kisselev A, Kim K, Al-Ayed K, van Rooden E, Xin B, Huber E, Overkleeft H. Structure-based design of β1i or β5i specific inhibitors of human immunoproteasomes. J Med Chem 2014; 57:6197-209.
15.07.2014Structure-based design of β1i or β5i specific inhibitors of human immunoproteasomes
15.07.2014J Med Chem 2014; 57:6197-209
de Bruin Gerjan, Groll Michael, van der Marel Gijsbert A, van der Stelt Mario, Driessen Christoph, Kisselev Alexei F, Kim Kyung-Bo, Al-Ayed Karol, van Rooden Eva J, Xin Bo-Tao, Huber Eva M, Overkleeft Herman S
Incorporation of non-natural amino acids improves cell permeability and potency of specific inhibitors of proteasome trypsin-like sites
Geurink P, Overkleeft H, Groll M, van der Stelt M, Driessen C, van der Marel G, Florea B, Mock E, Voges M, Blom A, de Bruin G, Gallastegui N, Mirabella A, van der Linden W, Kisselev A. Incorporation of non-natural amino acids improves cell permeability and potency of specific inhibitors of proteasome trypsin-like sites. J Med Chem 2013; 56:1262-75.
28.01.2013Incorporation of non-natural amino acids improves cell permeability and potency of specific inhibitors of proteasome trypsin-like sites
28.01.2013J Med Chem 2013; 56:1262-75
Geurink Paul P, Overkleeft Herman S, Groll Michael, van der Stelt Mario, Driessen Christoph, van der Marel Gijs A, Florea Bogdan I, Mock Elliot D, Voges Mathias J, Blom Annet E M, de Bruin Gerjan, Gallastegui Nerea, Mirabella Anne C, van der Linden Wouter A, Kisselev Alexei F
Syringolin A selectively labels the 20 S proteasome in murine EL4 and wild-type and bortezomib-adapted leukaemic cell lines
Clerc J, Overkleeft H, Driessen C, Dudler R, Bachmann A, Huber R, Groll M, Kraus M, Florea B, Kaiser M. Syringolin A selectively labels the 20 S proteasome in murine EL4 and wild-type and bortezomib-adapted leukaemic cell lines. Chembiochem : a European journal of chemical biology 2009; 10:2638-43.
02.11.2009Syringolin A selectively labels the 20 S proteasome in murine EL4 and wild-type and bortezomib-adapted leukaemic cell lines
02.11.2009Chembiochem : a European journal of chemical biology 2009; 10:2638-43
Clerc Jérôme, Overkleeft Herman S, Driessen Christoph, Dudler Robert, Bachmann André S, Huber Robert, Groll Michael, Kraus Marianne, Florea Bogdan I, Kaiser Markus
Endocytosis targets exogenous material selectively to cathepsin S in live human dendritic cells, while cell-penetrating peptides mediate nonselective transport to cysteine cathepsins
Reich M, van Swieten P, Sommandas V, Kraus M, Fischer R, Weber E, Kalbacher H, Overkleeft H, Driessen C. Endocytosis targets exogenous material selectively to cathepsin S in live human dendritic cells, while cell-penetrating peptides mediate nonselective transport to cysteine cathepsins. Journal of leukocyte biology 2007; 81:990-1001.
01.04.2007Endocytosis targets exogenous material selectively to cathepsin S in live human dendritic cells, while cell-penetrating peptides mediate nonselective transport to cysteine cathepsins
01.04.2007Journal of leukocyte biology 2007; 81:990-1001
Reich Michael, van Swieten Paul F, Sommandas Vinod, Kraus Marianne, Fischer Rainer, Weber Ekkehard, Kalbacher Hubert, Overkleeft Herman S, Driessen Christoph
Probing the potential of platinum(II) complexes for the inhibition of thiol-dependent enzymatic activity
van Zutphen S, Kraus M, Driessen C, van der Marel G, Overkleeft H, Reedijk J. Probing the potential of platinum(II) complexes for the inhibition of thiol-dependent enzymatic activity. Journal of inorganic biochemistry 2005; 99:1384-9.
01.06.2005Probing the potential of platinum(II) complexes for the inhibition of thiol-dependent enzymatic activity
01.06.2005Journal of inorganic biochemistry 2005; 99:1384-9
van Zutphen Steven, Kraus Marianne, Driessen Christoph, van der Marel Gijs A, Overkleeft Herman S, Reedijk Jan
Development of an isotope-coded activity-based probe for the quantitative profiling of cysteine proteases
van Swieten P, Ploegh H, van der Marel G, Driessen C, Leeuwenburgh M, Kalbacher H, Wong C, Reich M, Kessler B, van den Nieuwendijk A, Maehr R, Overkleeft H. Development of an isotope-coded activity-based probe for the quantitative profiling of cysteine proteases. Bioorganic & medicinal chemistry letters 2004; 14:3131-4.
21.06.2004Development of an isotope-coded activity-based probe for the quantitative profiling of cysteine proteases
21.06.2004Bioorganic & medicinal chemistry letters 2004; 14:3131-4
van Swieten Paul F, Ploegh Hidde L, van der Marel Gijsbert A, Driessen Christoph, Leeuwenburgh Michiel A, Kalbacher Hubert, Wong Chung-Sing, Reich Michael, Kessler Benedikt M, van den Nieuwendijk Adrianus M C H, Maehr Rene, Overkleeft Herman S
Human B lymphoblastoid cells contain distinct patterns of cathepsin activity in endocytic compartments and regulate MHC class II transport in a cathepsin S-independent manner
Lautwein A, Nordheim A, Kalbacher H, Weber E, Kammer W, Schwarz G, Overkleeft H, Brandenburg J, Burster T, Reich M, Kraus M, Driessen C. Human B lymphoblastoid cells contain distinct patterns of cathepsin activity in endocytic compartments and regulate MHC class II transport in a cathepsin S-independent manner. Journal of leukocyte biology 2004; 75:844-55.
01.05.2004Human B lymphoblastoid cells contain distinct patterns of cathepsin activity in endocytic compartments and regulate MHC class II transport in a cathepsin S-independent manner
01.05.2004Journal of leukocyte biology 2004; 75:844-55
Lautwein Alfred, Nordheim Alfred, Kalbacher Hubert, Weber Ekkehard, Kammer Winfried, Schwarz Gerold, Overkleeft Herman S, Brandenburg J, Burster Timo, Reich Michael, Kraus Marianne, Driessen Christoph
Antigen processing and presentation in human muscle: cathepsin S is critical for MHC class II expression and upregulated in inflammatory myopathies
Wiendl H, Tolosa E, Melms A, Lochmüller H, Overkleeft H, Weber E, Morgalla M, Wienhold W, Erfurth S, Krause S, Mitsdörffer M, Lautwein A, Driessen C. Antigen processing and presentation in human muscle: cathepsin S is critical for MHC class II expression and upregulated in inflammatory myopathies. Journal of neuroimmunology 2003; 138:132-43.
01.05.2003Antigen processing and presentation in human muscle: cathepsin S is critical for MHC class II expression and upregulated in inflammatory myopathies
01.05.2003Journal of neuroimmunology 2003; 138:132-43
Wiendl Heinz, Tolosa Eva, Melms Arthur, Lochmüller Hanns, Overkleeft Herman S, Weber Ekkehard, Morgalla Matthias, Wienhold Wolfgang, Erfurth Stella, Krause Sabine, Mitsdörffer Meike, Lautwein Alfred, Driessen Christoph
Activity and subcellular distribution of cathepsins in primary human monocytes
Greiner A, Lautwein A, Overkleeft H, Weber E, Driessen C. Activity and subcellular distribution of cathepsins in primary human monocytes. Journal of leukocyte biology 2003; 73:235-42.
01.02.2003Activity and subcellular distribution of cathepsins in primary human monocytes
01.02.2003Journal of leukocyte biology 2003; 73:235-42
Greiner Andrea, Lautwein Alfred, Overkleeft Herman S, Weber Ekkehard, Driessen Christoph
Inflammatory stimuli recruit cathepsin activity to late endosomal compartments in human dendritic cells
Lautwein A, Burster T, Lennon-Duménil A, Overkleeft H, Weber E, Kalbacher H, Driessen C. Inflammatory stimuli recruit cathepsin activity to late endosomal compartments in human dendritic cells. European journal of immunology 2002; 32:3348-57.
01.12.2002Inflammatory stimuli recruit cathepsin activity to late endosomal compartments in human dendritic cells
01.12.2002European journal of immunology 2002; 32:3348-57
Lautwein Alfred, Burster Timo, Lennon-Duménil Ana-Maria, Overkleeft Herman S, Weber Ekkehard, Kalbacher Hubert, Driessen Christoph