Herman Overkleeft
The novel β2-selective proteasome inhibitor LU-102 decreases phosphorylation of I kappa B and induces highly synergistic cytotoxicity in combination with ibrutinib in multiple myeloma cells.
Kraus J, Kraus M, Liu N, Besse L, Bader J, Geurink P, de Bruin G, Kisselev A, Overkleeft H, Driessen C. The novel β2-selective proteasome inhibitor LU-102 decreases phosphorylation of I kappa B and induces highly synergistic cytotoxicity in combination with ibrutinib in multiple myeloma cells. Cancer Chemother Pharmacol 2015; 76:383-96.
23.06.2015The novel β2-selective proteasome inhibitor LU-102 decreases phosphorylation of I kappa B and induces highly synergistic cytotoxicity in combination with ibrutinib in multiple myeloma cells.
23.06.2015Cancer Chemother Pharmacol 2015; 76:383-96
Kraus Johannes, Kraus Marianne, Liu Nora, Besse Lenka, Bader Jürgen, Geurink Paul P, de Bruin Gerjan, Kisselev Alexei F, Overkleeft Herman, Driessen Christoph
The novel β2-selective proteasome inhibitor LU-102 synergizes with bortezomib and carfilzomib to overcome proteasome inhibitor resistance of myeloma cells
Kraus M, Overkleeft H, Kisselev A, Li N, Appenzeller C, van Rooden E, Haile S, de Bruin G, van der Linden W, Shabaneh T, Silzle T, Mirabella A, Weyburne E, Geurink P, Bader J, Driessen C. The novel β2-selective proteasome inhibitor LU-102 synergizes with bortezomib and carfilzomib to overcome proteasome inhibitor resistance of myeloma cells. Haematologica 2015; 100:1350-60.
11.06.2015The novel β2-selective proteasome inhibitor LU-102 synergizes with bortezomib and carfilzomib to overcome proteasome inhibitor resistance of myeloma cells
11.06.2015Haematologica 2015; 100:1350-60
Kraus Marianne, Overkleeft Herman, Kisselev Alexei F, Li Nan, Appenzeller Christina, van Rooden Eva, Haile Sarah, de Bruin Gerjan, van der Linden Wouter A, Shabaneh Tamer B, Silzle Tobias, Mirabella Anne C, Weyburne Emily S, Geurink Paul P, Bader Juergen, Driessen Christoph
Ritonavir, nelfinavir, saquinavir and lopinavir induce proteotoxic stress in acute myeloid leukemia cells and sensitize them for proteasome inhibitor treatment at low micromolar drug concentrations
Kraus M, Müller-Ide H, Rückrich T, Bader J, Overkleeft H, Driessen C. Ritonavir, nelfinavir, saquinavir and lopinavir induce proteotoxic stress in acute myeloid leukemia cells and sensitize them for proteasome inhibitor treatment at low micromolar drug concentrations. Leuk Res 2013; 38:383-92.
25.12.2013Ritonavir, nelfinavir, saquinavir and lopinavir induce proteotoxic stress in acute myeloid leukemia cells and sensitize them for proteasome inhibitor treatment at low micromolar drug concentrations
25.12.2013Leuk Res 2013; 38:383-92
Kraus Marianne, Müller-Ide Hendrik, Rückrich Thomas, Bader Jürgen, Overkleeft Herman, Driessen Christoph
Human cytomegalovirus infection interferes with major histocompatibility complex type II maturation and endocytic proteases in dendritic cells at multiple levels
Kessler T, Reich M, Jahn G, Tolosa E, Beck A, Kalbacher H, Overkleeft H, Schempp S, Driessen C. Human cytomegalovirus infection interferes with major histocompatibility complex type II maturation and endocytic proteases in dendritic cells at multiple levels. The Journal of general virology 2008; 89:2427-36.
01.10.2008Human cytomegalovirus infection interferes with major histocompatibility complex type II maturation and endocytic proteases in dendritic cells at multiple levels
01.10.2008The Journal of general virology 2008; 89:2427-36
Kessler Tobias, Reich Michael, Jahn Gerhard, Tolosa Eva, Beck Alexander, Kalbacher Hubert, Overkleeft Herman, Schempp Susanne, Driessen Christoph
Dual inhibition of proteasomal and lysosomal proteolysis ameliorates autoimmune central nervous system inflammation
Fissolo N, Kraus M, Reich M, Ayturan M, Overkleeft H, Driessen C, Weissert R. Dual inhibition of proteasomal and lysosomal proteolysis ameliorates autoimmune central nervous system inflammation. European journal of immunology 2008; 38:2401-11.
01.09.2008Dual inhibition of proteasomal and lysosomal proteolysis ameliorates autoimmune central nervous system inflammation
01.09.2008European journal of immunology 2008; 38:2401-11
Fissolo Nicolas, Kraus Marianne, Reich Michael, Ayturan Miriam, Overkleeft Herman, Driessen Christoph, Weissert Robert
Ritonavir induces endoplasmic reticulum stress and sensitizes sarcoma cells toward bortezomib-induced apoptosis
Kraus M, Hartmann J, Koscielniak E, Ovaa H, Overkleeft H, Rückrich T, Müller H, Gogel J, Malenke E, Driessen C. Ritonavir induces endoplasmic reticulum stress and sensitizes sarcoma cells toward bortezomib-induced apoptosis. Molecular cancer therapeutics 2008; 7:1940-8.
01.07.2008Ritonavir induces endoplasmic reticulum stress and sensitizes sarcoma cells toward bortezomib-induced apoptosis
01.07.2008Molecular cancer therapeutics 2008; 7:1940-8
Kraus Marianne, Hartmann Jörg Thomas, Koscielniak Ewa, Ovaa Huib, Overkleeft Herman, Rückrich Thomas, Müller Holger, Gogel Jeannette, Malenke Elke, Driessen Christoph
Interferon-gamma regulates cathepsin G activity in microglia-derived lysosomes and controls the proteolytic processing of myelin basic protein in vitro
Burster T, Tolosa E, Overkleeft H, Kalbacher H, Youssef S, Boehm B, Falk K, Roetzschke O, Reich M, Baechle D, Øren A, Poeschel S, Beck A, Driessen C. Interferon-gamma regulates cathepsin G activity in microglia-derived lysosomes and controls the proteolytic processing of myelin basic protein in vitro. Immunology 2007; 121:82-93.
01.05.2007Interferon-gamma regulates cathepsin G activity in microglia-derived lysosomes and controls the proteolytic processing of myelin basic protein in vitro
01.05.2007Immunology 2007; 121:82-93
Burster Timo, Tolosa Eva, Overkleeft Herman, Kalbacher Hubert, Youssef Sawsan, Boehm Bernhard O, Falk Kirsten, Roetzschke Olaf, Reich Michael, Baechle Daniel, Øren Anita, Poeschel Simone, Beck Alexander, Driessen Christoph
Differential processing of autoantigens in lysosomes from human monocyte-derived and peripheral blood dendritic cells
Burster T, Overkleeft H, Weber E, Häring H, Kalbacher H, Kraus M, Reich M, Weissert R, Schnorrer P, Tolosa E, Beck A, Driessen C. Differential processing of autoantigens in lysosomes from human monocyte-derived and peripheral blood dendritic cells. Journal of immunology (Baltimore, Md. : 1950) 2005; 175:5940-9.
01.11.2005Differential processing of autoantigens in lysosomes from human monocyte-derived and peripheral blood dendritic cells
01.11.2005Journal of immunology (Baltimore, Md. : 1950) 2005; 175:5940-9
Burster Timo, Overkleeft Herman, Weber Ekkehard, Häring Hans-Ulrich, Kalbacher Hubert, Kraus Marianne, Reich Michael, Weissert Robert, Schnorrer Petra, Tolosa Eva, Beck Alexander, Driessen Christoph