Bereich
Institut für Immunbiologie
IMMBIO · Dept. Direktion
Immunopathological pathways underlying myocarditis and inflammatory cardiomyopathy – an exploratory study
24.07.2023Primary objective: Analysis of cardiac antigen- and microbiota-reactive CD4+ T cell and B cell response during development of cardiac inflammation. Secondary objectives: Analysis of clinical data, cardiac imaging and immunological parameters (HLA de...
Klinische Forschung - 24.07.2023 - 24.07.2024
Automatisch geschlossen
Projektleitung: Ludewig Burkhard
Mitarbeiter/innen: Rickli Hans, Maeder Micha, Vetsch Susanne
T cell responses in myocarditis, inflammatory cardiomyopathy and heart failure
22.06.2023
Grundlagenforschung - 22.06.2023 - 31.12.2024
Automatisch geschlossen
Projektleitung: Ludewig Burkhard
Regulation of lymphoid organ fibroblast differentiation and function by bone morphogenic proteins
01.01.2023
Grundlagenforschung - 01.01.2023 - 31.12.2026
Laufend
Projektleitung: Ludewig Burkhard
Entschlüsselung der krebsassoziierten Fibroblastenlandschaft bei malignen Erkrankungen des ZNS
01.01.2023
Grundlagenforschung - 01.01.2023 - 31.12.2023
Automatisch geschlossen
Projektleitung: Pikor Natalia
Fibroblastendifferenzierung und -funktion im Tonsillenkarzinom
24.06.2022
Grundlagenforschung - 24.06.2022 - 31.12.2023
Automatisch geschlossen
Projektleitung: Ludewig Burkhard
Mitarbeiter/innen: Meili Samuel
Deep immune cell phenotyping in patients suffering from HPV-positive tonsillar squamous cell carcinoma
01.03.2022
Grundlagenforschung - 01.03.2022 - 31.08.2025
Laufend
Projektleitung: Stanossek Yves
Mitarbeiter/innen: Meili Samuel, Ludewig Burkhard, De Martin Angelina, Kurz Lisa
Tissue Cytokines at the Nexus of Immune Cell-Cardiac Stromal Cell Interaction-CardiacStroma
01.01.2022
Grundlagenforschung - 01.01.2022 - 30.12.2026
Laufend
Projektleitung: Ludewig Burkhard
Elucidating mechanisms of disease pathogenesis in a coronavirus-induced model of Multiple Sclerosis
01.11.2021
Grundlagenforschung - 01.11.2021 - 31.12.2022
Automatisch geschlossen
Projektleitung: Pikor Natalia
Transcriptomic analysis of fibroblasts in brain tumors – an exploratory study
19.06.2020The aim of this study was to evaluate to what extent the fibroblastic landscape is remodelled in human brain metastases and to employ high-resolution transcriptomic and histological analyses to characterize cancer-associated fibroblasts in these CNS...
Grundlagenforschung - 19.06.2020 - 02.08.2024
Abgeschlossen
Projektleitung: Pikor Natalia
Deciphering the molecular landscape of the stromal cells in human lymph nodes at the single-cell level
01.09.2019
Grundlagenforschung - 01.09.2019 - 31.03.2025
Laufend
Projektleitung: Ludewig Burkhard
Mitarbeiter/innen: Stanossek Yves, Meili Samuel, De Martin Angelina, Lütge Mechthild, Kurz Lisa, Cheng Hung-Wei
Stromal Cell Niches at the Nexus of the Innate Lymphoid Cell Interactome
01.01.2019Innate lymphoid cells (ILCs) critically impact a diverse array of diseases. While the main cell-intrinsic molecular pathways and some of the soluble mediators that regulate ILC development and their functional activity have been characterized, the ce...
Grundlagenforschung - 01.01.2019 - 31.12.2022
Automatisch geschlossen
Projektleitung: Ludewig Burkhard
Mitarbeiter/innen: Lütge Mechthild
Transcriptomic analysis of the B and T cell repertoire in Multiple Sclerosis – an exploratory study
01.01.2019Multiple Sclerosis (MS) is an immune-mediated disease of the central nervous system (CNS). While T cells dominate the immune response, both B and T cells contribute to the demyelination and neuronal injury that underlies clinical disease manifestatio...
Grundlagenforschung - 01.01.2019 - 31.01.2019
Automatisch geschlossen
Projektleitung: Pikor Natalia, Ludewig Burkhard
Deciphering the transcriptomic landscape of cancer-associated fibroblasts in pancreatic cancer / Oncological Research
01.01.2019Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive cancer types with a 5-year survival of only 7% and strongly limited treatment options. A major obstacle for successful treatment is the immunosuppressive nature of the tumor microe...
Grundlagenforschung - 01.01.2019 - 31.12.2021
Automatisch geschlossen
Projektleitung: Ludewig Burkhard, Lütge Mechthild
Inorganic Nanoparticles with Anti-inflammatory and Antimicrobial Activity: New Prospects for Long-term Local Immunoimodulation?
01.01.2019Control and eventual attenuation of inflammation is important in the management of a plethora of diseases. However, suppression of inflammatory responses, e.g. by corticosteroids or systemic blockade of immune effector pathways, is associated with se...
Grundlagenforschung - 01.01.2019 - 31.12.2019
Automatisch geschlossen
Projektleitung: Ludewig Burkhard, Herrmann Inge
Identification and manipulation of immune-stimulating fibroblastic stromal cell niches in the inflamed CNS
01.01.2019The unique anatomy of the central nervous system (CNS) necessitates that inflammation in this organ is limited. However, emerging studies reveal that focal inflammation may be more prominent than previously appreciated. Avenues for immune surveill...
Grundlagenforschung - 01.01.2019 - 30.06.2023
Automatisch geschlossen
Projektleitung: Pikor Natalia, Ludewig Burkhard
Deciphering the transcriptomic landscape of cancer-associated fibroblasts in pancreatic cancer – an exploratory clinical study
01.07.2018Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive cancer types with a 5-year survival of only 7% 1. While surgical resection of localized disease offers a moderate increase in survival, patients with metastatic pancreas cancer are...
Grundlagenforschung - 01.07.2018 - 31.12.2018
Abgeschlossen
Projektleitung: Ludewig Burkhard
Mitarbeiter/innen: Lütge Mechthild
Dissecting the association of anti-microbiota antibodies and auto-reactive T-cells in cardiomyopathy– an exploratory research Project
25.01.2018Prospective research project in which biological material is sampled from humans and health-related personal data is collected (HFV Art 6). To generate further scientific evidence for a potential role of crossreactive antimicrobial T and B cell respo...
Klinische Forschung - 25.01.2018 - 25.08.2021
Abgeschlossen
Projektleitung: Ludewig Burkhard
Mitarbeiter/innen: Maeder Micha, Vetsch Susanne
Defining the identity and differentiation pathways of the immune-stimulating fibroblastic tumor stroma
01.01.2018Lung cancer is the most frequent cause of death in cancer patients in industrialized countries. A particular property of non-small cell lung cancer is the composition of the tumor microenvironment (TME) with a very high proportion of stromal cells. W...
Grundlagenforschung - 01.01.2018 - 31.12.2021
Automatisch geschlossen
Projektleitung: Ludewig Burkhard
Mitarbeiter/innen: De Martin Angelina
Dissecting the association of the human palatine tonsil microbiome and HPV-driven oropharyngeal squamous cell carcinoma
01.01.2017Oropharyngeal squamous cell carcinoma (OPSCC) can be caused by viral transformation of epithelial cells in the oropharynx such as high risk-human papilloma virus (HR-HPV). Importantly, the incidence of OPSCC has been increasing during the last decade...
Grundlagenforschung - 01.01.2017 - 31.12.2018
Automatisch geschlossen
Projektleitung: Ludewig Burkhard
Mitarbeiter/innen: Broglie Däppen Martina, Stöckli Sandro, Cupovic Jovana
Constructing accessory lymph nodes in situ for control of mammary carcinoma
01.07.2016Lymph nodes (LNs) are situated at junctures of the blood vascular and the lymphatic system where antigens drain from peripheral tissues via afferent lymphatics. The decision whether and how immune responses against tumors are initiated and maintained...
Grundlagenforschung - 01.07.2016 - 30.06.2019
Automatisch geschlossen
Projektleitung: Ludewig Burkhard
Mitarbeiter/innen: Cupovic Jovana