Unit
Pathologie
PI · Dept. IV
The Role of the Inorganics in Preeclampsia Assessed by Multiscale Characterization of Placentae
Nov 1, 2020
Fundamental Research - Nov 1, 2020 - Dec 30, 2021
Automatically Closed
Project leader: Herrmann Inge
Members: Rduch Thomas, Gogos Alexander, Tsolaki Elena, Leschka Sebastian, Born Diana, Fischer Tina, Hornung René
Lymphopenie bei myeloproliferativen Neoplasien: Prävalenz und prognostische Bedeutung
Jul 1, 2020Eine Lymphopenie als Ausdruck einer Störung des adaptiven Immunsystems ist ein etablierter Risikofaktor bei verschiedenen Allgemein- und Tumorerkrankungen. Im Hinblick auf myeloische Neoplasien konnte im Rahmen eines Kooperationsprojektes des KSSG m...
Clinical Studies - Jul 1, 2020 - Jun 30, 2022
Automatically Closed
Project leader: Silzle Tobias
Members: Messerich Nora-Medea, Cogliatti Sergio B., Lehmann Thomas, Graf Lukas
Exploring indirect embryo-fetal risks of nanomaterials: Interference with inflammatory, vascular and endocrine signaling from human placental tissue
Oct 1, 2018Nanomaterialien können Gewebebarrieren wie Lunge und Darm durchdringen und im Körper zu Schädigungen in Zellen und Geweben führen. Während der Schwangerschaft ist ein Kontakt mit Nanomaterialien besonders problematisch, da der Fötus sehr empfindlich...
Fundamental Research - Oct 1, 2018 - Sep 30, 2021
Automatically Closed
Project leader: Buerki-Thurnherr Tina
Members: Hornung René, Jochum Wolfram, Patrycja Nowak-Sliwinska
Evaluation of Controlled Attenuated Parameter (CAP) for Assessment of Liver Steatosis in an Unselected Population: a Single Center Real Life Experience
Dec 16, 2015Background & Aims: Controlled attenuated parameter (CAP) is a new parameter to assess steatosis of the liver, which is obtained together with elastography. Our aim was to assess the performance of CAP in an unselected population with different liver...
Clinical Studies - Dec 16, 2015 - Dec 16, 2017
Completed
Project leader: Baumeler Stephan
Members: Semela David, Bergamin Irina, Jochum Wolfram, Neuweiler Jörg
Next Generation Sequencing-enabled Diagnostics as a Cornerstone for Personalized (Nano-)Medicine
Jul 9, 2015
Fundamental Research - Jul 9, 2015 - Jul 9, 2016
Completed
Project leader: Jochum Wolfram
SINGLE ARM OPEN LABLE PHASE II PILOT STUDY OF CARBOPLATIN
Dec 2, 2014Study design: For the pilot trial a single stage phase II design was chosen. All patients that meet the eligibility criteria will receive carboplatin AUC3 until progression (radiological or clinical). A total of 25 patients are required for this stud...
Clinical Studies - Dec 2, 2014 - Dec 31, 2017
Automatically Closed
Project leader: Omlin Aurelius
Members: Gillessen Sommer Silke, Haile Sarah, Jochum Wolfram
Verteilung der Werte des Proliferationsmarkers Ki-67 am Kantonsspital St.Gallen
Oct 15, 20141b.1. Hintergrund Der Proliferationsmarker Ki-67 wird in der Onkologie ubiquitär verwendet. Bei der Behandlung von Brustkrebs hat er ein spezielles Gewicht bekommen, da bei einem häufigen Subtyp von Brustkrebs (Luminal-B) die Indikation für eine adju...
Clinical Studies - Oct 15, 2014 - Sep 26, 2015
Completed
Project leader: Ruhstaller Thomas
Members: Öhlschlegel Christian, Jochum Wolfram, Thürlimann Beat
Impact of HPV on outcome in surgically treated patients with OPSCC
Jan 1, 2014Impact of HPV positivity (based on detection of p16 protein and high risk HPV-DNA in tumor tissue samples) in relation to tumor stage, grade of differentiation, gender, age and other risk factors (smoking habits, alcohol consumption, T- and N-categor...
Clinical Studies - Jan 1, 2014 - Dec 31, 2014
Completed
Project leader: Broglie Däppen Martina
Members: Stöckli Sandro, Jochum Wolfram
Cancer of unknown primary – Rolle von HPV für Diagnose und Outcome
Sep 1, 2013
Clinical Studies - Sep 1, 2013 - Aug 1, 2014
Completed
Project leader: Broglie Däppen Martina
Members: Jochum Wolfram, Vorburger Melanie, Stöckli Sandro
A randomized phase II trial of pertuzumab in combination with trastuzumab with or without chemotherapy, both followed by T-DM1 in case of progression, in patients with HER2-positive metastatic breast cancer
May 1, 2013The primary objective of this trial is to evaluate the efficacy in terms of overall survival (OS) at 24 months of a chemotherapy-free dual HER2-inbibition with trastuzumab and pertuzumab (first-line) followed by T-DM1 (second-line) and of a chemother...
Clinical Studies - May 1, 2013 - May 1, 2019
Automatically Closed
Project leader: Weder Patrik
Members: Thürlimann Beat, Ruhstaller Thomas, Maier Reinhard, Riniker Salome, Öhlschlegel Christian, Hasler-Strub Ursula
SAKK 22/10: A randomized phase II trial of pertuzumab in combination with trastuzumab with or without chemothera-py, both followed by T-DM1 in case of progression, in pa-tients with HER2-positive metastatic breast cancer
Apr 29, 2013In der vorliegenden Studie wird eine neue Strategie für die Behandlung des HER2-positiven metastasierenden Brustkrebses untersucht, bei der die Erstlinientherapie aus Herceptin® und Perjeta® besteht und somit chemotherapiefrei ist. Bei Fortschreiten...
Clinical Studies - Apr 29, 2013 - Jun 27, 2015
Automatically Closed
Project leader: Weder Patrik
Members: Ruhstaller Thomas, Hasler-Strub Ursula, Maier Reinhard, Öhlschlegel Christian, Riniker Salome, Kaelin Martin, Hochstrasser Andreas, Thürlimann Beat
HPV-Positivität beim Oropharynxkarzinom - Indikation für eine Strahlentherapie
Apr 1, 2012
Clinical Studies - Apr 1, 2012 - Dec 31, 2013
Completed
Project leader: Broglie Däppen Martina
Members: Stöckli Sandro, Jochum Wolfram
Molecular and mutational profiling in Papillary Thyroid Carcinoma with special emphasis on the influence of BRAFV600E Mutation on Tumor Stage, Outcome and nuclear imaging
Jan 21, 2011Background: The optimal treatment of papillary thyroid carcinoma (PTC) is still a matter of debate, despite the usually excellent prognosis of patients with this tumor type. Markers are needed to identify patients with high risk of recurrence. The BR...
Clinical Studies - Jan 21, 2011 - Dec 30, 2013
Completed
Project leader: Broglie Däppen Martina
Members: Stöckli Sandro, Clerici Thomas, Brändle Michael, Bilz Stefan, Müller Joachim, Oettli Rene, Jochum Wolfram, Haile Sarah
Randomisierte Phase III Studie zu Bestrahlungsdosen und Fraktionierungsschemata bei duktalem Carcinoma in situ (DCIS) der Brust mit mittlerem und hohem Rückfallrisisko
Nov 2, 2010Multizentrische, offene, randomiserite Phase III-Studie zur Untersuchung der Bestrahlungsdosen und Fraktionierungsschemata der Radiotherapie bei DCIS der Brust. Ziel der Studie ist, die Strahlentherapie zu optimieren und die Krankheit bei geringstmög...
Clinical Studies - Nov 2, 2010 - Dec 31, 2015
Automatically Closed
Project leader: Stolz Anja
Members: Plasswilm Ludwig, Öhlschlegel Christian