Indeterminate dendritic cell tumor in the pancreas

Publication

Indeterminate dendritic cell tumor in the pancreas

Journal Paper/Review - Jul 16, 2020

Sortino Rosita, Schmid Michael, El Baz Yassir, Loosen Antonia, Tarantino Ignazio, Steffen Thomas, Schmied Bruno, Abbassi Fariba

Citation

Sortino R, Schmid M, El Baz Y, Loosen A, Tarantino I, Steffen T, Schmied B, Abbassi F. Indeterminate dendritic cell tumor in the pancreas. J Surg Case Rep 2020; 2020:rjaa208.

Type

Journal Paper/Review (English)

Journal

J Surg Case Rep 2020; 2020

Publication Date

Jul 16, 2020

Issn Print

2042-8812

Pages

rjaa208

Brief description/objective

Indeterminate dendritic cell tumor (IDCT) is an extremely rare hematologic neoplastic disorder with proliferation of indeterminate dendritic cells. In the vast majority of cases, IDCTs are restricted to the skin or lymph nodes. To our knowledge, we report the first case of IDCT in the pancreas. Due to the rarity of extracutaneous IDCT, guidelines or treatment recommendations addressing their management are missing. We performed a review of literature to compare our experience to the management of other extracutaneous IDCT. Histopathological examination confirms the diagnosis of IDCT in electron microscopy and/or immunohistochemistry. Specific features are the lack of Birbeck granules and the nonreaction to Langerin antibodies. Concerning the aftercare of extracutaneous IDCT, we recommend a dermatological examination to rule out an additional cutaneous manifestation as well as annual blood examinations due to the association between IDCT and hematologic malignancies.