Impact of human papillomavirus on outcome in patients with oropharyngeal cancer treated with primary surgery
Journal Paper/Review - Jul 10, 2017
Broglie Däppen Martina, Müller Martin, Spreitzer Stefan, Lang Florian, Lutchmaya Mathieu, Stauffer Edouard, Espeli Vittoria, Martucci Francesco, Bongiovanni Massimo, Foerbs Diana, Arnoux Andre, Dettmer Matthias, Arnold Andreas, Stöckli Sandro, Sauter Rafael, Pasche Philippe, Reinhard Antoine, de Leval Laurence, Huber Gerhard F, Pezier Thomas F, Soltermann Alex, Giger Roland, Jochum Wolfram
Knowledge about prognostic factors in surgically treated patients with oropharyngeal squamous cell carcinoma (SCC) is limited. The purpose of this study was to identify influential factors on survival in a large cohort of patients with surgically treated oropharyngeal SCC.
Retrospective analysis of survival estimates in patients with surgically treated oropharyngeal SCC using tumoral positivity for human papillomavirus (HPV) and risk-of-death categories according to a study from 2010 as stratification factors.
The 5-year overall survival (OS) and disease-specific survival (DSS) rates after surgery alone were higher in HPV-associated oropharyngeal SCC (OS 80% vs 62%; P = .01; DSS 92% vs 76%; P = .03). Patients in the low-risk category had higher survival rates (OS 91%; DSS 99%) than patients in the intermediate-risk group (OS 63%; DSS 83%), and high-risk group (OS 61%; DSS 75%).
Nonsmokers with HPV-positive oropharyngeal SCC have a better prognosis than smokers with HPV-positive oropharyngeal SCC and also than patients with HPV-negative tumors when treated by surgery alone.