A mathematical approach for optimising dendritic cell-based immunotherapy

Publication

A mathematical approach for optimising dendritic cell-based immunotherapy

Book Chapter - Jan 1, 2005

Ludewig Burkhard, Bocharov Gennady, Ford Neville, Hoffmann Matthias

Units

Medizinisches Forschungszentrum, Institute of Immunobiology, Division of Infectious Diseases, Infection Prevention and Travel Medicine

Keywords

Dendritic Cells, T cells

Citation

Ludewig B, Bocharov G, Ford N, Hoffmann M. A mathematical approach for optimising dendritic cell-based immunotherapy. In: Adoptive Immunotherapy - Methods and Protocols. Totowa, New Jersey: Human Press, 2005. ISBN 1-59259-862-5. pp. 19-34.

Type

Book Chapter (English)

Book Title

Adoptive Immunotherapy - Methods and Protocols

Publication Date

Jan 1, 2005

Series Title

Methods in Molecular Medicine (109)

Isbn Number

1-59259-862-5

Pages

19-34

Publisher

Human Press (Totowa, New Jersey)

Brief description/objective

Adoptive dendritic cell-based immunotherapy represents a promising approach to overcome peripheral tolerance against autologous tumor antigens and to maintain protective antitumor immunity. The translation of successful preclinical studies, however, appears to be hampered by new complexities associated with the clinical situation. Mathematical modelling provides the means for qualitative and quantitative analysis, predictions for complex dynamic systems in immunology, and for the design and improvement of therapeutic approaches. We present here a workable computational methodology for developing meaningful data- and hypothesis-driven mathematical models for DC-based immunotherapy with a particular focus on numerical parameter estimation and sensitivity analysis.