A mathematical approach for optimising dendritic cell-based immunotherapy

Publikation

A mathematical approach for optimising dendritic cell-based immunotherapy

Buchkapitel - 01.01.2005

Ludewig Burkhard, Bocharov Gennady, Ford Neville, Hoffmann Matthias

Bereiche

Medizinisches Forschungszentrum, Institut für Immunbiologie, Infektiologie | Infektionsprävention | Reisemedizin

Schlagwörter (Tags)

Dendritic Cells, T cells

Zitation

Ludewig B, Bocharov G, Ford N, Hoffmann M. A mathematical approach for optimising dendritic cell-based immunotherapy. In: Adoptive Immunotherapy - Methods and Protocols. Totowa, New Jersey: Human Press, 2004. ISBN 1-59259-862-5. S. 19-34.

Art

Buchkapitel (Englisch)

Buchtitel

Adoptive Immunotherapy - Methods and Protocols

Veröffentlichungsdatum

01.01.2005

Titel der Reihe

Methods in Molecular Medicine (109)

ISBN Nummer

1-59259-862-5

Seiten

19-34

Verlag

Human Press (Totowa, New Jersey)

Kurzbeschreibung/Zielsetzung

Adoptive dendritic cell-based immunotherapy represents a promising approach to overcome peripheral tolerance against autologous tumor antigens and to maintain protective antitumor immunity. The translation of successful preclinical studies, however, appears to be hampered by new complexities associated with the clinical situation. Mathematical modelling provides the means for qualitative and quantitative analysis, predictions for complex dynamic systems in immunology, and for the design and improvement of therapeutic approaches. We present here a workable computational methodology for developing meaningful data- and hypothesis-driven mathematical models for DC-based immunotherapy with a particular focus on numerical parameter estimation and sensitivity analysis.