Acetaminophen increases blood pressure in patients with coronary artery disease
Journal Paper/Review - Oct 18, 2010
Sudano Isabella, Nussberger Juerg, Mocharla Pavani, Landmesser Ulf, Haile Sarah, Corti Roberto, Vanhoutte Paul M, Lüscher Thomas F, Noll Georg, Holzmeister Johannes, Gay Steffen, Neidhart Michel, Flammer Andreas J, Périat Daniel, Enseleit Frank, Hermann Matthias, Wolfrum Mathias, Hirt Astrid, Kaiser Priska, Hurlimann David, Ruschitzka Frank
Because traditional nonsteroidal antiinflammatory drugs are associated with increased risk for acute cardiovascular events, current guidelines recommend acetaminophen as the first-line analgesic of choice on the assumption of its greater cardiovascular safety. Data from randomized clinical trials prospectively addressing cardiovascular safety of acetaminophen, however, are still lacking, particularly in patients at increased cardiovascular risk. Hence, the aim of this study was to evaluate the safety of acetaminophen in patients with coronary artery disease.