Acetaminophen increases blood pressure in patients with coronary artery disease

Publication

Acetaminophen increases blood pressure in patients with coronary artery disease

Journal Paper/Review - Oct 18, 2010

Sudano Isabella, Nussberger Juerg, Mocharla Pavani, Landmesser Ulf, Haile Sarah, Corti Roberto, Vanhoutte Paul M, Lüscher Thomas F, Noll Georg, Holzmeister Johannes, Gay Steffen, Neidhart Michel, Flammer Andreas J, Périat Daniel, Enseleit Frank, Hermann Matthias, Wolfrum Mathias, Hirt Astrid, Kaiser Priska, Hurlimann David, Ruschitzka Frank

Citation

Sudano I, Nussberger J, Mocharla P, Landmesser U, Haile S, Corti R, Vanhoutte P, Lüscher T, Noll G, Holzmeister J, Gay S, Neidhart M, Flammer A, Périat D, Enseleit F, Hermann M, Wolfrum M, Hirt A, Kaiser P, Hurlimann D, Ruschitzka F. Acetaminophen increases blood pressure in patients with coronary artery disease. Circulation 2010; 122:1789-96.

Type

Journal Paper/Review (English)

Journal

Circulation 2010; 122

Publication Date

Oct 18, 2010

Issn Electronic

1524-4539

Pages

1789-96

Brief description/objective

Because traditional nonsteroidal antiinflammatory drugs are associated with increased risk for acute cardiovascular events, current guidelines recommend acetaminophen as the first-line analgesic of choice on the assumption of its greater cardiovascular safety. Data from randomized clinical trials prospectively addressing cardiovascular safety of acetaminophen, however, are still lacking, particularly in patients at increased cardiovascular risk. Hence, the aim of this study was to evaluate the safety of acetaminophen in patients with coronary artery disease.