T-cell factor-4 frameshift mutations occur frequently in human microsatellite instability-high colorectal carcinomas but do not contribute to carcinogenesis

Publication

T-cell factor-4 frameshift mutations occur frequently in human microsatellite instability-high colorectal carcinomas but do not contribute to carcinogenesis

Journal Paper/Review - Jun 1, 2002

Ruckert Stefan, Kirchner Thomas, Brabletz Thomas, Rüschoff Josef, Koch Claudia, Haynl Angela, Dietmaier Wolfgang, Beyser Kurt, Oswald Ursula, Brueckl Wolfgang M, Hiendlmeyer Elke, Jung Andreas

Units

Clinical Trials Unit

PubMed

12036905

Citation

Ruckert S, Kirchner T, Brabletz T, Rüschoff J, Koch C, Haynl A, Dietmaier W, Beyser K, Oswald U, Brueckl W, Hiendlmeyer E, Jung A. T-cell factor-4 frameshift mutations occur frequently in human microsatellite instability-high colorectal carcinomas but do not contribute to carcinogenesis. Cancer Res 2002; 62:3009-13.

Type

Journal Paper/Review (English)

Journal

Cancer Res 2002; 62

Publication Date

Jun 1, 2002

Issn Print

0008-5472

Pages

3009-13

Brief description/objective

Colorectal carcinomas with microsatellite instability accumulate errors in short repetitive DNA repeats, especially mono and dinucleotide repeats. One such error-prone A(9) monorepeat is found in exon 17 of the TCF-4 gene. TCF-4 and beta-catenin form a transcription complex, which is important for both maintenance of normal epithelium and development of colorectal tumors. To elucidate the relevance of frameshift mutations in the TCF-4 in colorectal carcinogenesis, a variety of investigations in human tumors and cell lines was performed. It was found that mutations in the TCF-4 A(9) repeat do not contribute to tumorigenesis and seem to be passenger mutations.