Preservation of kidney function in kidney transplant recipients by alkali therapy (Preserve-Transplant Study): rationale and study protocol.

Publication

Preservation of kidney function in kidney transplant recipients by alkali therapy (Preserve-Transplant Study): rationale and study protocol.

Journal Paper/Review - Jul 13, 2018

Wiegand Anna, Ritter Alexander, Graf Nicole, Arampatzis Spyridon, Sidler Daniel, Hadaya Karine, Müller Thomas F, Wagner Carsten A, Wüthrich Rudolf P, Mohebbi Nilufar

Citation

Wiegand A, Ritter A, Graf N, Arampatzis S, Sidler D, Hadaya K, Müller T, Wagner C, Wüthrich R, Mohebbi N. Preservation of kidney function in kidney transplant recipients by alkali therapy (Preserve-Transplant Study): rationale and study protocol. BMC Nephrol 2018; 19:177.

Type

Journal Paper/Review (English)

Journal

BMC Nephrol 2018; 19

Publication Date

Jul 13, 2018

Issn Electronic

1471-2369

Pages

177

Brief description/objective

Graft survival after kidney transplantation has significantly improved within the last decades but there is a substantial number of patients with declining transplant function and graft loss. Over the past years several studies have shown that metabolic acidosis plays an important role in the progression of Chronic Kidney Disease (CKD) and that alkalinizing therapies significantly delayed progression of CKD. Importantly, metabolic acidosis is highly prevalent in renal transplant patients and a recent retrospective study has shown that metabolic acidosis is associated with increased risk of graft loss and patient death in kidney transplant recipients. However, no prospective trial has been initiated yet to test the role of alkali treatment on renal allograft function.