Projects
Search from 1164 projects:
1164 Project(s)
SAKK 39/10
Apr 11, 2012Patient/innen dieser Studie leiden an einer bösartigen Er-krankung des Knochenmarkes, dem Multiplen Myelom (MM) und die Erkrankung spricht nicht mehr auf die Stan-dardtherapie (Lenalidomid (Revlimid®)/ Dexamethason) an. Nach Therapieversagen sind der...
Clinical Studies - Apr 11, 2012 - Jun 11, 2014
Automatically Closed
Project leader: Hitz Felicitas
Members: Driessen Christoph
Quality Assurance of Prostate Cancer Radiotherapy Guidelines
Apr 5, 2012The aim of our project is the comparison of guidelines for the primary radiotherapy of prostate cancer among institutions in Switzerland. The goal is not the leveling of guidelines, but a neutral description of deviations, which may lead to a critic...
Clinical Studies - Apr 5, 2012 - Apr 5, 2013
Automatically Closed
Project leader: Putora Paul Martin
Members: Plasswilm Ludwig, Horstkemper Ruth
Non-Interventional Cohort Study on the Utilization and Impact of Dual and Triple Therapies Based on Pegylated Interferon for the Treatment of Chronic Hepatitis C
Apr 2, 2012Beurteilung der Wirksamkeit von Kombinationstherapien mit Peginterferon alpha plus Ribavirin und Therapieschemata mit direkt wirkenden antiviralen Substanzen bei CHC-Patienten, die diese Medikamente im Rahmen der klinischen Routinepraxis gemäss den l...
Clinical Studies - Apr 2, 2012 - Nov 30, 2014
Completed
Project leader: Semela David
Members: Borovicka Jan, Frei Remus, Sulz Michael, Sawatzki Mikael, Semadeni Gian-Marco, Künzler-Heule Patrizia, Weinmann Sabine
An International, Multi-Center Study Evaluating the Correlation of IL28B Genotypes with Chronic Hepatitis C Disease Characteristics and Patient Demographics
Apr 2, 2012Korrelation zwischen den Interleukin 28B - (IL28B-) Genotypen rs12979860 (CC vs. TC vs. TT) und rs8099917 (TT vs. GT vs. GG) und CHC-assoziierter Leberfibrose
Clinical Studies - Apr 2, 2012 - May 30, 2014
Completed
Project leader: Semela David
Members: Borovicka Jan, Frei Remus, Sawatzki Mikael, Semadeni Gian-Marco, Sulz Michael, Künzler-Heule Patrizia, Weinmann Sabine
An observational study to assess persistence, adherence, quality of life, and treatment satisfaction in patients beginning therapy with the Avonex® PEN™
Apr 1, 2012An observational study to assess persistence, adherence, quality of life, and treatment satisfaction in patients beginning therapy with the Avonex® PEN™
Clinical Studies - Apr 1, 2012 - Apr 1, 2013
Completed
Project leader: Müller Stefanie
A 32-week, patient- and rater-blinded, randomized, multicenter, parallel-group study to evaluate disease control and safety in patients with relapsing remitting multiple sclerosis transferred from previous treatment with natalizumab to fingolimod (FTY720)
Apr 1, 2012A 32-week, patient- and rater-blinded, randomized, multicenter, parallel-group study to evaluate disease control and safety in patients with relapsing remitting multiple sclerosis transferred from previous treatment with natalizumab to fingolimod (FT...
Clinical Studies - Apr 1, 2012 - Dec 1, 2012
Aborted
Project leader: Müller Stefanie
HPV-Positivität beim Oropharynxkarzinom - Indikation für eine Strahlentherapie
Apr 1, 2012
Clinical Studies - Apr 1, 2012 - Dec 31, 2013
Completed
Project leader: Broglie Däppen Martina
Members: Stöckli Sandro, Jochum Wolfram
Circulating micro-RNA profiling in patients with advanced non-squamous non small-cell lung cancer receiving bevacizumab/erlotinib first-line treatment followed by platinum-based chemotherapy at disease progression (SAKK 19/05)
Apr 1, 2012Background: This study was initiated by the Swiss Group for Clinical Cancer Research (SAKK) 19/05 study to assess the predictive and prognostic value of circulating miRNA profiles from peripheral blood of patients with non-squamous non small-cell lu...
Fundamental Research - Apr 1, 2012 - Sep 1, 2013
Completed
Project leader: Brutsche Martin
Members: Jörger Markus, Zappa Francesco, Gautschi Oliver, Pless Miklos, Ochsenbein Adrian, Bubendorf Lukas, von Moos Roger, Betticher Daniel, Stahel Rolph, Früh Martin, Baty Florent
Description of relapse in frequency and accompanying factors in germ cell cancer patients – an observational study
Mar 30, 2012About 400 men are diagnosed with testicular cancer in Switzerland every year [1]. In the last three decades substantial progress has been made in the treatment of testicular cancer: The majority of patients with metastatic testicular cancer can be cu...
Clinical Studies - Mar 30, 2012 - Jun 30, 2015
Aborted
Project leader: Gillessen Sommer Silke
Members: Rothermundt Christian, Cathomas Richard
Basket Small 2
Mar 21, 2012BASKET-SMALL 2 A prospective, randomized, controlled, open label, multicenter trial to test the non-inferiority of drug eluting balloon vs. drug eluting stent treatment in de novo stenoses of small native vessels regarding efficacy and safety
Clinical Studies - Mar 21, 2012 - Mar 21, 2016
Completed
Project leader: Weilenmann Daniel
Members: Rickli Hans, Gemperle Michaela, Schefer Mirjam
Long term responders to first line chemotherapy plus cetuximab in recurrent/metastatic head and neck cancer: a genomic landscape approach to identify predictive biomarkers
Mar 11, 2012The majority of squamocellular head and neck cancer (SCC HNC) patients presenting with advanced disease stage will eventually relapse either locoregionally and/or at distant sites. Patients with recurrent and/or metastatic (RM) disease who are not ca...
Clinical Studies - Mar 11, 2012 - Jul 11, 2012
Automatically Closed
Untersuchung des Einfluss der Haarprobenahme zur Qualitätssicherung in der Haaranalytik
Mar 7, 2012Haaranalytik ist ein etabliertes Tool zum Nachweis des Konsums psychotroper Substanzen und Alkohol über einen längeren Zeitraum - auch noch mehrere Monate nach Einnahme der entsprechenden Substanzen. In der Schweiz findet die Haaranalytik überwiegend...
Clinical Studies - Mar 7, 2012 - Nov 30, 2012
Automatically Closed
Project leader: Klemm Clementine
Retrospective Analysis of mistletoe-induced fever in cancer patients
Mar 1, 2012Fieberreaktionen gehen gelegentlich sogenannten Spontanremissionen maligner Erkrankungen voraus. In anthroposophischen Kliniken werden Mistelpräparate teilweise intravenös (off label) verabreicht, mit dem Ziel eine fieberhafte Reaktion zu induzieren....
Clinical Studies - Mar 1, 2012 - Dec 31, 2014
Completed
Project leader: Huber Roman
Members: Schlaeppi Marc, Templeton Arnoud, Kühn Johanes
Funktionelle Charakterisierung und therapeutische Nutzung des mesenchymalen Tumorstromas
Mar 1, 2012Das Thema des geplanten Forschungsprojekts ist die funktionelle Charakterisierung und therapeutische Nutzung des mesenchymalen Tumorstromas. Neben den eigentlichen Tumorzellen, die unterschiedliche genetische Veränderungen aufweisen, finden sich im T...
Fundamental Research - Mar 1, 2012 - Feb 28, 2014
Completed
Project leader: Ludewig Burkhard
Members: Onder Lucas
A Phase III, Multicenter, Randomized, Double-Blind, Placebo-Controlled Safety Study of Xolair (Omalizumab) in Patients With Chronic Idiopathic Urticaria (CIU) Who Remain Symptomatic Despite Treatment With H1 Antihistamines, H2 Blockers, and/or Leukotriene Receptor Antagonists
Feb 19, 2012The study is a global Phase III, multicenter, randomized, double-blind, placebo controlled, parallel-group study to evaluate the safety and efficacy of omalizumab administered subcutaneously as an add-on therapy for the treatment of adolescent and ad...
Clinical Studies - Feb 19, 2012 - Jun 19, 2013
Automatically Closed
Project leader: Anliker Mark
Hystlab
Feb 19, 2012
Clinical Studies - Feb 19, 2012 - Aug 19, 2012
Completed
Project leader: Bolla Daniele
Pronek
Feb 19, 2012
Clinical Studies - Feb 19, 2012 - Aug 19, 2012
Completed
Project leader: Schyrba Viktor, Bolla Daniele
An open, multicentric phase II trial to evaluate the efficacy and safety of Bendamustine, Lenalidomide (Revlimid®) and Dexamethasone (BRd) as 2nd-line therapy for patients with relapsed or refractory multiple myeloma
Feb 17, 2012Therapie des rezidivierten bzw. therapierefraktären Multiplen Myeloms nach Erstlinientherapie Fast alle Patienten, die an einem Multiplen Myelom erkrankt sind, erleiden nach der ersten Therapie einen Rückfall Ihrer Erkrankung. Verschiedene Kombinat...
Clinical Studies - Feb 17, 2012 - Jul 17, 2014
Automatically Closed
Project leader: Driessen Christoph, Mey Ulrich
Members: Hiendlmeyer Elke, Clavadetscher Luzia
Master Protokoll: A Program of randomized phase II multicenter sudies to assess the tolerability and efficacy of the addition of new drugs to standard induction chemotherapy in AML and RAEB ≥ 66 years and cery poor risk AML ≥ years
Feb 9, 2012Auch ältere Patienten in gutem Allgemeinzustand profitieren von einer intensiven Chemotherapie, die Remissionsraten und auch das Gesamtüberleben sind jedoch deutlich schlechter als bei jüngeren Patienten. Insgesamt erreichen ca. 50% aller Patienten e...
Clinical Studies - Feb 9, 2012 - Feb 9, 2016
Automatically Closed
Project leader: Hess Urs
Members: Baumann Michael, Driessen Christoph, Hitz Felicitas
Eine randomisierte, doppelblinde klinische Prüfung der Phase III zur Untersuchung der Wirksamkeit, Si-cherheit und Verträglichkeit von TMC435 vs. Telaprevir, beide in Kombination mit PegIFNα-2a und Ribavirin, bei Patienten mit chronischer Hepatitis-C-Genotyp-1-Infektion, die bei einer früheren Therapie mit PegIFNα- und Ribavirin Null- oder partielle Responder waren
Feb 6, 2012To demonstrate the non-inferiority of TMC435 versus telaprevir (TVR), both given in combination with peginterferon-alfa-2a (PegIFNα-2a) and ribavirin (RBV), by less than 12% with respect to the proportion of subjects with sustained virologic response...
Clinical Studies - Feb 6, 2012 - May 31, 2014
Completed
Project leader: Semela David
Members: Borovicka Jan, Sulz Michael, Sawatzki Mikael, Semadeni Gian-Marco, Künzler-Heule Patrizia, Weinmann Sabine