Projects
Search from 1133 projects:
1133 Project(s)
Early protected full weight-bearing vs. partial weight-bearing after surgical fixation of unstable ankle fractures, monitored with bio-feedback insoles. A single blinded randomized controlled study
Sep 1, 2023adhere to instructions concerning weight-bearing. The purpose of this study is to compare the postoperative results after ORIF with a PWB protocol versus an early FWB protocol. But in addition, we will measure every patient’s actual load by the mean...
Clinical Studies - Sep 1, 2023 - Oct 31, 2026
Scheduled
Project leader: Potocnik Primoz, Toepfer Andreas
Targeting des Immunoproteasoms in vivo
Aug 1, 2023Proteasome sind vielversprechende Angriffspunkte für Medikamente bei Krebserkrankungen. Mehrere Proteasom-Inhibitoren werden bereits klinisch zur Behandlung des multiplen Myeloms (MM) eingesetzt. Aktuelle in der Klinik eingesetzte Proteasom-Inhibitor...
Fundamental Research - Aug 1, 2023 - Dec 31, 2023
Automatically Closed
Project leader: Driessen Christoph
Members: Mendez Lopez Max, Besse Lenka
Immunopathological pathways underlying myocarditis and inflammatory cardiomyopathy – an exploratory study
Jul 24, 2023Primary objective: Analysis of cardiac antigen- and microbiota-reactive CD4+ T cell and B cell response during development of cardiac inflammation. Secondary objectives: Analysis of clinical data, cardiac imaging and immunological parameters (HLA de...
Clinical Studies - Jul 24, 2023 - Jul 24, 2024
Ongoing
Project leader: Ludewig Burkhard
Members: Rickli Hans, Maeder Micha, Vetsch Susanne
A Randomized, Open-label, Phase 3 Study of Tarlatamab Compared With Standard of Care in Subjects with Relapsed Small Cell Lung Cancer After Platinum-based First Line chemotherapy (DeLLphi-304)
Jul 17, 2023
Clinical Studies - Jul 17, 2023 - Dec 31, 2025
Ongoing
Project leader: Früh Martin
Members: Hutter Franziska, Quinter Janine
Retrospective and prospective registry of patients with metastatic NSCLC harboring typical and atypical EGFR mutations
Jul 3, 2023
Clinical Studies - Jul 3, 2023 - Dec 31, 2030
Ongoing
Project leader: Früh Martin
Members: Radovanovic Suzana, Frehner Jan
Leptomeningeal Collaterals in INtracErebral Hemorrhage: Association with Hematoma Size and Expansion
Jul 3, 2023Die intrazerebrale Blutung (ICB) ist eine verheerende Form des Schlaganfalls, die mit einer hohen Morbidität und Mortalität einhergeht. Die Ausdehnung des Hämatoms trägt wesentlich zu den schlechten Ergebnissen bei ICB-Patienten bei und gilt als beei...
Clinical Studies - Jul 3, 2023 - Jan 1, 2025
Ongoing
Project leader: Dittrich Tolga, De Marchis Gian Marco
Members: Zell Daniel
Meaningful Patient and Public Involvement in the SHCS: A methods review and mixed-method study
Jul 1, 2023
Clinical Studies - Jul 1, 2023 - Oct 31, 2024
Ongoing
Project leader: Notter Julia
Members: Jackson-Perry David
Swiss Cardiac Amyloidosis Registry
Jul 1, 2023The aim of the Swiss-CARE registry is a comprehensive collection of clinical data and a follow-up of patients diagnosed with cardiac amyloidosis. Patients with and without therapy will be included in the registry. This will allow us to better under...
Register - Jul 1, 2023 - Jul 1, 2033
Ongoing
Project leader: Ehl Niklas
Members: Schneider Irene
Swiss Secondary Prevention and Rehabilitation Registry: SwissPR
Jul 1, 2023The rationale of this prospective longitudinal cohort study is to determine the short and long-term effects of an ambulatory cardiac rehabilitation program on key cardiovascular benchmark performance measures and its effects on major adverse cardiova...
Register - Jul 1, 2023 - Dec 31, 2040
Ongoing
Project leader: Buser Marc
Members: Schneider Irene
Prevalence and screening of NAFLD and fibrosis in type 2 diabetes - a SwissDiab study
Jul 1, 2023
Clinical Studies - Jul 1, 2023 - Oct 31, 2024
Ongoing
Members: Renström Frida, Bilz Stefan, Brändle Michael
Frequency and Clinical Significance of PR3- and MPO Antineutrophil Cytoplasmic Antibodies (ANCA) in Ulcerative Colitis and Crohn’s Disease (IBD-ANCA Study)
Jul 1, 2023Antineutrophil cytoplasmic antibodies (ANCA), especially PR3- and MPO-ANCA, are major biomarkers for the diagnosis of ANCA-associated vasculitis. Several recent studies suggested that PR3-ANCA may also be detected in 18–53% of patients with ulcerativ...
Clinical Studies - Jul 1, 2023 - Jul 1, 2025
Ongoing
Project leader: Truniger Samuel, Brand Stephan
Members: Koller Seraina, König Marius
T cell responses in myocarditis, inflammatory cardiomyopathy and heart failure
Jun 22, 2023
Fundamental Research - Jun 22, 2023 - Dec 31, 2023
Automatically Closed
Project leader: Ludewig Burkhard
Evaluation des Einflusses von HLA-Genpolymorphismen auf das T-Zell-RezeptorRepertoire und T-Zell-Spezifitäten bei Patientinnen und Patienten mit nicht-kleinzelligem Lungenkarzinom unter Immun-Checkpoint-Inhibitor-Therapie
Jun 22, 2023
Fundamental Research - Jun 22, 2023 - Dec 31, 2024
Ongoing
Project leader: Flatz Lukas
Members: Sieber Pablo
A Phase 1/2 Study of BMS-986408 Alone and in Combination with Nivolumab or with Nivolumab and Ipilimumab in Participants with Advanced Solid Tumors
Jun 21, 2023Das primäre Ziel dieser Studie ist die Charakterisierung des Sicherheitsprofils von BMS-986408 als Monotherapie und in Kombination mit Nivolumab oder Nivolumab und Ipilimumab, um die maximal verträgliche Dosis (MTD) zu ermitteln. Außerdem soll die em...
Clinical Studies - Jun 21, 2023 - Dec 31, 2030
Ongoing
Project leader: Jörger Markus
Members: Hutter Franziska, Frehner Jan
Oceanic AF
Jun 1, 2023A multicenter, international, randomized, active comparator-controlled, double-blind, doubledummy, parallel-group, 2-arm, Phase 3 study to compare the efficacy and safety of the oral FXIa inhibitor asundexian (BAY 2433334) with apixaban for the preve...
Clinical Studies - Jun 1, 2023 - Jun 30, 2024
Completed
Project leader: Rickli Hans
Members: Fink Karin, Vetsch Susanne
Impact of Tenofovir disoproxil fumarate/Emtricitabine (TDF/FTC) on the gut microbiome and microbiome-mediated toxicity of TDF/FTC in men using event-based HIV Pre- Exposure prophylaxis
Jun 1, 2023
Clinical Studies - Jun 1, 2023 - Mar 31, 2025
Ongoing
Project leader: Notter Julia
Members: Kahlert Christian
AmplatzerTM PFO Occluder and AmplatzerTM TalismanTM PFO Occluder PAS (“PFO PAS”) AmplatzerTM PFO Occluder and AmplatzerTM TalismanTM PFO Occluder Post Approval Study
Jun 1, 2023PFO PAS is a singel arm, multinational post-market study in patients with PFO after ischemic stroke (paradoxical embolism). Screening via PFO colloquium. Study Objectives; To demonstrate safety of the Amplatzer PFO Occluder and Amplatzer Talisman P...
Clinical Studies - Jun 1, 2023 - Jun 1, 2028
Ongoing
Project leader: Chronis Joannis
Members: Meier Jessica, Vetsch Susanne
Determining postoperative recovery and the impact of adverse events in neurosurgery based on self-reported, app-based longitudinal assessment – a collaborative observational research project
Jun 1, 2023Der Einfluss einer Operation und deren Nebenwirkungen auf das subjektive Befinden eines Patienten zu verstehen ist enorm wichtig, um künftige Patienten bei deren Entscheidung für oder gegen eine Operation mit den entsprechenden Risiken und Vorteilen...
Clinical Studies - Jun 1, 2023 - Jun 1, 2025
Ongoing
Project leader: Stienen Martin N.
Boehringer Ingelheim BI1366-0031_456906_SSc
May 22, 2023A Phase II, randomised, placebo-controlled, double-blind, parallel-group, efficacy and safety study of at least 48 weeks of oral BI 685509 treatment in adults with early progressive diffuse cutaneous systemic sclerosis
Clinical Studies - May 22, 2023 - May 22, 2026
Ongoing
Project leader: Rubbert-Roth Andrea
Members: Schmiedeberg Kristin, Bartz-Batliner Mira, Peischl Shirin, Gostic Dragana
A PHASE IB/II RANDOMIZED, OPEN LABEL DRUG REPURPOSING TRIAL OF GLUTAMATE SIGNALING INHIBITORS IN COMBINATION WITH CHEMORADIOTHERAPY IN PATIENTS WITH NEWLY DIAGNOSED GLIOBLASTOMA (GLUGLIO)
May 10, 2023Die Studie untersucht die Wirksamkeit einer Kombination der Studienmedikamente Gabapentin, Sulfasalazin und Memantin zusammen mit der Standardtherapie (Strahlentherapie und Chemotherapie mit Temozolomid). Alle drei Studienmedikamente hemmen an unters...
Clinical Studies - May 10, 2023 - Dec 31, 2030
Ongoing
Project leader: Hundsberger Thomas
Members: Harder Anja, Frehner Jan