Projects
Search from 1164 projects:
1164 Project(s)
Covid 19 Impfantwort, Bedarf und Reaktion auf mögliche Booster- Impfung bei Patienten mit soliden Neoplasien
Oct 1, 2021Patienten mit malignen Erkrankungen stellen eine durch die SARS-CoV-2-Pandemie hoch gefährdete Gruppe dar mit einem hohen Hospitalisations- und Mortalitätsrisiko. Eine Impfung gegen SARS-COV2 stellt neben allgemeinen Schutzmassnahmen das wichtigste E...
Clinical Studies - Oct 1, 2021 - Feb 28, 2021
Automatically Closed
Project leader: Fischer Stefanie
Members: Silzle Tobias, Demmer-Steingruber Ruth, Albrich Werner, Kahlert Christian
ALK-Inhibitoren als potentielle Therapie bei Proteasom-Inhibitor-resistentem Multiplen Myelom
Oct 1, 2021
Fundamental Research - Oct 1, 2021 - Sep 30, 2023
Automatically Closed
Project leader: Driessen Christoph
Members: Besse Lenka, Besse Andrej, Kraus Marianne
EVOKE
Sep 30, 2021A Research Study Investigating Semaglutide in People With Early Alzheimer's Disease (EVOKE) This study is done to find out whether semaglutide has a positive effect on early Alzheimer's disease. Participants will either get semaglutide or placebo - w...
Clinical Studies - Sep 30, 2021 - Dec 31, 2025
Ongoing
Project leader: Felbecker Ansgar
CARE-HK in HF Registry
Sep 30, 2021This study is a multinational, multicentre, non-interventional, cohort study of assessment and treatment guideline recommendations in HF patient care in a real-world setting.
Clinical Studies - Sep 30, 2021 - Dec 31, 2025
Completed
Project leader: Maeder Micha
Members: Vetsch Susanne, Schneider Irene
Studie der Phase 2 zur Beurteilung der Wirksamkeit und Sicherheit von Pembrolizumab plus Prüfpräparate in Kombination mit Etoposid und Cisplatin oder Carboplatin als Erstlinientherapie bei Teilnehmenden mit kleinzelligem Lungenkrebs im fortgeschrittenen Stadium (MK-3475- B99)
Sep 29, 2021Die Studie untersucht die Sicherheit und Wirkung von Pembrolizumab plus Chemotherapie in Kombination mit neuen, experimentellen Substanzen. Es werden voraussichtlich weltweit rund 40 Patienten pro Therapiearm teilnehmen, wobei jeder Therapiearm aus d...
Clinical Studies - Sep 29, 2021 - Oct 28, 2028
Ongoing
Project leader: Schmid Sabine
Efficacy and safety comparison of brodalumab versus guselkumab in adult subjects with moderate -to -severe plaque psoriasis and inadequate response to ustekinumab; COBRA / Phase 4 – efficacy trial A randomised, blinded, parallel-group, multi-site, clinical trial
Sep 13, 2021
Clinical Studies - Sep 13, 2021 - Nov 16, 2022
Completed
Project leader: Cozzio Antonio
Amgen 20200234
Sep 8, 2021A Phase 2b Dose Ranging Study to Evaluate the Efficacy and Safety of Efavaleukin Alfa in Subjects with Active Systemic Lupus Erythematosus With Inadequate Response to Standard of Care Therapy.
Clinical Studies - Sep 8, 2021 - Apr 6, 2023
Aborted
Project leader: Rubbert-Roth Andrea
Members: Peischl Riana
Encorafenib plus binimetinib in patients with locally advanced, unresectable or metastatic BRAFV600-mutated melanoma: a multi-centric, national, prospective, longitudinal, non-interventional study in Switzerland – BERINGMELANOMA
Sep 7, 2021
Clinical Studies - Sep 7, 2021 - Oct 1, 2027
Ongoing
Project leader: Wagner Nikolaus
TEAR und EARLY ALS
Sep 1, 2021Hintergrund der Studie zur Analyse von Tränenflüssigkeit (TEAR-ALS) ist die Identifizierung von Biomarkern. Tränendrüsen haben eine enge anatomische Beziehung zum Hirnstamm, welcher eine zentrale Rolle bei neurodegenerativen Erkrankungen spielt. Ein...
Fundamental Research - Sep 1, 2021 - Mar 31, 2024
Automatically Closed
Project leader: Neuwirth Christoph
Members: Braun Nathalie
BMS CA224-104 Phase 2 Randomized Double-blind Study of Relatlimab plus Nivolumab in Combination with Chemothera-py vs. Nivolumab in Combination with Chemotherapy as First Line Treatment for Participants with Stage IV or Recurrent Non-small Cell Lung Cancer (NSCLC)
Jul 30, 2021Immunotherapy plays substantial role in first line treatment of NSCLC Stage IV. Current standard of care is – depending on PD-L1 expression- anti-PD-(L)1 alone or in combination with PDCT which has demonstrated significant improvements in OS as well...
Clinical Studies - Jul 30, 2021 - Dec 31, 2025
Ongoing
CAR T- Cell EBMT Registry data processing framework
Jul 30, 2021
Clinical Studies - Jul 30, 2021 - Dec 31, 2026
Ongoing
Project leader: Fehr Martin
Members: Breuss Kim, Müller Fiona
Phase 2 Randomized Double-blind Study of Relatlimab plus Nivolumab in Combination with Chemotherapy vs. Nivolumab in Combination with Chemotherapy as First Line Treatment for Participants with Stage IV or Recurrent Non-small Cell Lung Cancer (NSCLC)
Jul 30, 2021Diese Studie besteht aus zwei Hauptteilen. In der Schweiz wurde Teil 1 bereits beendet. In Teil 1 werden verschiedene Dosen Relatlimab zusammen mit Nivolumab und Chemotherapie verabreicht, um sicherzustellen, dass die Prüfpräparat-Kombination bei Pat...
Clinical Studies - Jul 30, 2021 - Dec 31, 2026
Ongoing
Project leader: Weindler Susanne
Members: Berbic Hong Phuong
MSD MK1308A-004
Jul 3, 2021Phase 2, Multicenter, Clinical Study to Evaluate the Safety and Efficacy of MK-1308A (Coformulated MK-1308/MK-3475) in Combination with Lenvatinib (E7080/MK-7902) in First-line Therapy of Participants with Advanced Hepatocellular Carcinoma
Clinical Studies - Jul 3, 2021 - Dec 3, 2022
Automatically Closed
Project leader: Semela David
Members: Stillhard Roman, Bergamin Irina
Immunoproteasome activity as a predictive marker and therapeutic target in hematological malignancies
Jul 1, 2021
Fundamental Research - Jul 1, 2021 - Dec 31, 2021
Automatically Closed
Project leader: Besse Andrej
Members: Kraus Marianne, Besse Lenka
SAKK 15/19 Thoracic radiotherapy plus maintenance Durvalumab after first line Carboplatin and Etoposide plus Durvalumab in extensive-stage disease small cell lung cancer (EDSCLC) A multicenter single arm open label phase il trial
Jun 24, 2021Standard of care for Extensive-Stage Disease (ED) Small Cell Lung Cancer (SCLC) as first-line treatment is 4 to 6 cycles of platinum based chemotherapy (carboplatin or cisplatin) in combination with etoposide. However, the outcome of the disease...
Clinical Studies - Jun 24, 2021 - Jun 28, 2027
Ongoing
Project leader: Früh Martin
Members: Demmer-Steingruber Ruth, Quinter Janine
ALFA ROMEO
Jun 23, 2021Atrial fibrillation before and after patent foramen ovale closure study This is a prospective, multicenter, single-arm, observational study assessing the incidence, predictors and prognostic impact of AF occurring before (monitoring phase A) or af...
Clinical Studies - Jun 23, 2021 - Jun 23, 2027
Ongoing
Project leader: Chronis Joannis
Members: Schneider Irene, Vetsch Susanne
SWISS-AF Control Group
Jun 17, 2021Contemporary findings from the ongoing Swiss-AF cohort study (2’415 patients with atrial fibrillation (AF) enrolled, 1’760 patients with available brain imaging) showed that patients with AF have a high burden of cerebral infarcts and other brain les...
Clinical Studies - Jun 17, 2021 - Jun 17, 2025
Ongoing
Project leader: Ammann Peter
Members: Fink Karin
Assessing a ctDNA and PET-oriented therapy in patients with DLBCL multicenter, open-label, phase II trial
Jun 8, 2021Despite advances in the clinical care of patients with DLBCL and in understanding the biology of this disease, cure rates have remained the same since the introduction of rituximab to CHOP chemotherapy, and RCHOP chemoimmunotherapy remains the standa...
Clinical Studies - Jun 8, 2021 - Dec 31, 2030
Ongoing
Project leader: Hitz Felicitas
Members: Harder Anja, Quinter Janine
Application of smart sensor insoles for assessment of gait parameters and correlation to patient-reported outcomes in hip arthroplasty patients
Jun 1, 2021Gait parameters like gait velocity, stride length, cadence or load symmetry contribute to a successful outcome after total hip arthroplasty (THA) and can be addressed through targeted physiotherapeutic training programs. Instrumented gait analysis i...
Fundamental Research - Jun 1, 2021 - Jun 30, 2025
Scheduled
Project leader: Ladurner Andreas
Members: Giesinger Karlmeinrad
Analysis of the maturation of the peripheral nervous system in neonates, infants and children using high-resolution ultrasound imaging
Jun 1, 2021During early childhood nerve conduction velocity (NCS) increases from 20m/s at the time of birth to almost adult values of 50m/s at two years of age. How this increase in NCS is correlated to the structural maturation of the peripheral nerves is unkn...
Clinical Studies - Jun 1, 2021 - Jun 1, 2023
Automatically Closed
Members: Broser Philip