Projects
Search from 1147 projects:
1147 Project(s)
Impact of immune regulation on virus-induced chronic CNS inflammation and demyelination
Jan 1, 2008Background: Multiple sclerosis (MS) is an important disease affecting young adults. Epidemiological studies indicate that this disease critically depends on environmental factors, including infectious agents. It appears that infections with a variety...
Fundamental Research - Jan 1, 2008 - Dec 31, 2008
Completed
Project leader: Ludewig Burkhard
Members: Cervantes-Barragan Luisa, Eugster Karin
The significance of sensory function for the recovery of hand paresis after ischemic stroke
Jan 1, 2008Schlaganfälle bleiben trotz verbesserter Akutversorgung weiterhin eine der häufigsten Ursachen für bleibende Behinderung in den Industrienationen. Kenntnisse darüber wie und warum sich das Gehirn im subakuten und chronischen Stadium nach einem Insult...
Clinical Studies - Jan 1, 2008 - Dec 31, 2010
Automatically Closed
Protocole multicentrique de traitement
Nov 1, 2007Le protocole GRAALL-2005 est stratifié dès la fin de la préphase sur le caractère Ph (translocation 9 ;22 et/ou BCR-ABL+), et pour les LAL de la lignée B non-Ph1 sur l’expression du CD20 ou non. Il se subdivise donc vite en 3 études. Les deux premièr...
Clinical Studies - Nov 1, 2007 - Nov 1, 2015
Automatically Closed
Project leader: Hess Urs
Members: Driessen Christoph, Räss Andrea
ALTITUDE
Oct 24, 2007A randomized, double-blind, placebo-controlled, parallel-group study to determine whether, in patients with type 2 diabetes at high risk for cardiovascular and renal events, aliskiren, on top of conventional treatment, reduces cardiovascular and rena...
Clinical Studies - Oct 24, 2007 - Oct 24, 2011
Completed
Project leader: Rickli Hans
Reverse genetic analysis of coronavirus replication
Oct 1, 2007The reverse genetic system for the mouse hepatitis virus (MHV) in combination with a murine model for coronavirus infection allows for the use of genetically modified virus and host strains to assess the full range of virus-host interactions and to d...
Fundamental Research - Oct 1, 2007 - Sep 30, 2010
Completed
Project leader: Thiel Volker
Members: Nussbacher Monika, Züst Roland
A prospective, multi-center, double-blind, randomized, placebo-controlled, parallel-group study to assess the efficacy and safety of clazosentan in reducing vasospasm-related morbidity and all-cause mortality in adult patients with aneurysmal subarachnoid hemorrhage treated by surgical clipping
Sep 1, 2007Aneurysmal subarachnoid hemorrhage has been designated as an orphan disease and remains an important cause of morbidity and mortality despite advances in medical and surgical therapy. One important complication of subarachnoid hemorrhage is cerebral...
Clinical Studies - Sep 1, 2007 - Mar 31, 2010
Automatically Closed
Project leader: Seule Martin, Hildebrandt Gerhard
Members: Gautschi Oliver
MONET
Sep 1, 2007Eine randomisierte, kontrollierte, offene, klinische Prüfung zum Vergleich der Wirksamkeit, Sicherheit und Verträglichkeit einer vereinfachten Behandlung mit Darunavir/Ritonavir (DRV/r) 800/100 mg einmal täglich mit einer DRV/r enthaltenden Dreifach-...
Clinical Studies - Sep 1, 2007 - Dec 31, 2011
Completed
Project leader: Vernazza Pietro
SHIPP: Swiss HIV Positive Prevention
Aug 31, 2007Eine konstant hohe Zahl von HIV-Neuinfektionen in der Schweiz erfordert innovative Präventionsstrategien. Da viele Neuinfektionen in festen Partnerschaften stattfinden, sollte die Prävention auch Menschen die bereits mit einer HIV-Infektion leben ein...
Clinical Studies - Aug 31, 2007 - Aug 31, 2010
Automatically Closed
Project leader: Nicca Dunja
Members: Vernazza Pietro
Master protocol for mantle cell lymphoma A multicenter stratified phase II trial testing Everolimus (RAD001) for the treatment of patientswith newly diagnosed and relapsed or therapy resistant mantle cell lymphoma
Aug 20, 2007Das Mantelzell-Lymphom (MCL) gehört zu den Non-Hodgkin-Lymphomen und stellt eine bösartige Erkrankung des Immunsystems, insbesondere der Lymphozyten des Blutes dar. Die Krankheit betrifft in der Regel Patienten im sechsten Lebensjahrzehnt, präsentier...
Clinical Studies - Aug 20, 2007 - Dec 31, 2009
Automatically Closed
Project leader: Hitz Felicitas
Members: Pfister Bogumila
Randomized placebo-controled, double-blind exploratory trial of Bosentan for steroid resistant pulmonary sarcoidosis - the BOSSA study
Jul 1, 2007
Clinical Studies - Jul 1, 2007 - Jul 1, 2013
Completed
Project leader: Brutsche Martin
Members: Baty Florent, Burger Barbara
E-MOSAIC: A multicentre randomised controlled trial of longitudinal electronic monitoring of symptoms and syndromes associated with advanced cancer in patients treated with chemotherapy in palliative intention
May 27, 2007RATIONALE: A hand held electronic tool used to monitor symptoms and assess quality of life may improve communication between patients and their doctors and improve the ability to plan treatment for patients with advanced cancer receiving palliative c...
Clinical Studies - May 27, 2007 - Mar 31, 2012
Completed
Project leader: Strasser Florian
Members: Linder Susanne, Blum David, Kehl Jeanine
Role of professional and non-professional antigen presenting cells in cardiovascular immunopathological disease
Apr 1, 2007The importance of chronic inflammatory processes in the pathogenesis of cardiovascular diseases is now widely recognized. Atherosclerosis and autoimmune myocarditis are prototypical diseases illustrating the detrimental effects of constant immune act...
Fundamental Research - Apr 1, 2007 - Mar 31, 2010
Completed
Project leader: Ludewig Burkhard
Members: Eugster Karin, Nindl Veronika
Multiepitop Imfpung von Grad III/IV Melanompatienten mit dendritischen Zellen: Bedeutung von Peptidaffinität und -dichte für die optimale Generierung von tumorspezifischen zytotoxischen T-Lymphozyten
Jan 1, 2007Die immunologische Forschung der letzten Jahre hat deutlich gemacht, dass Krebszellen Zielstrukturen, sogenannte Antigene, produzieren, die sie für einen Angriff durch spezifische Immunzellen sensibilisieren. Die effektivste Waffe des Immunsystems ge...
Clinical Studies - Jan 1, 2007 - Dec 31, 2009
Completed
Project leader: Ludewig Burkhard, Gillessen Sommer Silke, Cerny Thomas
Members: Maier Reinhard, Templeton Arnoud
Immunpathologie der Virus induzierten Chorioretinitis
Jan 1, 2007Die Chorioretinitis ist eine häufig zu visuellen Wahrnehmungsstörungen (Sehbehinderung oder gar Erblindung) führende Erkrankung. Ursache der sich flächenhaft ausdehnenden und rasch progredienten Erkrankung der Netzhaut sind oftmals virale Infektionen...
Fundamental Research - Jan 1, 2007 - Dec 31, 2009
Completed
Project leader: Ludewig Burkhard
Preventing autoimmune myocarditis through cardiac myosin-specific tolerance
Jan 1, 2007The exact pathological basis of human myocarditis has not yet been sufficiently clarified and therefore, the appropriate treatment has remained a major clinical problem. Assuming that immunopathological damage contributes to the inflammatory nature o...
Fundamental Research - Jan 1, 2007 - Dec 31, 2009
Completed
Project leader: Ludewig Burkhard
Members: Nindl Veronika, Maier Reinhard
Untersuchung zur optimalen Anfangsdosierung der Blut-verdünnung mit Marcoumar®
Jan 1, 2007Hintergrund: Marcoumar® (Phenprocoumon) ist das am häufigsten verwendete Blutverdünnungsmittel in Europa. Für eine rasche Blutverdünnung (Antikoagulation) mit Marcoumar® wird meist eine Ladedosis verwendet. Die notwendige Dosis variiert jedoch enorm...
Clinical Studies - Jan 1, 2007 - Dec 31, 2009
Completed
Project leader: Henz Samuel
Die Pathogenese von Prionerkrankungen in Mäusen mit humanem Immunsystem / vereinfachtes Verfahren
Jan 1, 2007Etablierung eines Bioassays zur Überprüfung potentieller und bekannter humanpatogener Prionenstämme (CWD, sCJD, vDJD, BSE) in humanisierten Mäusen
Fundamental Research - Jan 1, 2007 - Nov 30, 2010
Completed
Project leader: Drack Gero
Members: Fischer Tina
AIDS-CoVAC: Generation of a coronavirus-based multigene AIDS vaccine and evaluation in a preclinical SIV model
Dec 1, 2006Coronaviruses spread via mucosal surfaces and can infect dendritic cells. These features and their exceptional transcription strategy make them extremely promising candidate vaccine vectors to overcome known problems of current HIV vaccine approaches...
Fundamental Research - Dec 1, 2006 - May 31, 2009
Completed
Project leader: Ludewig Burkhard, Thiel Volker
Members: Eugster Karin, Cervantes-Barragan Luisa, Makia Divine
IBD-Kohorte
Dec 1, 2006Retrospektive und prospektive multizentrische Cohorten-Studie ohne therapeutische Interventinen. Es werden Informationen zum klinischen Verlauf der chronisch-entzündlichen Darmerkrankungen erhoben. Diese Informationen werdern zum Teil aus den Kranken...
Clinical Studies - Dec 1, 2006 - Dec 31, 2015
Automatically Closed
Project leader: Borovicka Jan
Members: Frei Remus, Krieger-Grübel Claudia, Meyenberger Christa, Sawatzki Mikael, Semadeni Gian-Marco, Sulz Michael, Knellwolf Christina, Künzler-Heule Patrizia
The European Palliative Care Research Collaborative. Improved treatment of pain, depression and fatigue through translation research
Nov 1, 2006Summary description of project objectives Objective 1 To identify genes and genetic variation relevant for inter-individual variation in opioid responses and genetic variation that may identify patients at particular risk for developing cachexia Obje...
Clinical Studies - Nov 1, 2006 - Oct 31, 2010
Completed
Project leader: Strasser Florian
Members: Linder Susanne, Omlin Aurelius, Oberholzer Rolf, Blum David