Project

Pleural pharmacokinetics of moxifloxacin and amoxicillin-clavulanate in the context of parapneumonic pleural effusions and empyema

Completed · 2011 until 2012

Type
Clinical Studies
Range
Monocentric project at KSSG
Units
Status
Completed
Start Date
2011
End Date
2012
Financing
Industry
Study Design
Within-patient design, clinical pharmacology (PK/PD) phase IV study
Keywords
Moxifloxacin, Amoxicillin-Clavulanate, Parapneumonic Pleural Effusion, Pharmacokinetik, PK, PK/PD
Brief description/objective

The main objective of the study is the characterization of the PK profiles of moxifloxacin and amoxicillin clavulanate in the pleural fluid of patients with parapneumonic effusions using population PK-analysis. Intra- and interpatient variability will be assessed, and the quantitative influence of various covariates on the PK-profile of both drugs will be assessed.