Thomas Kirchner
Status quo of ALK testing in lung cancer: results of an EQA scheme based on in-situ hybridization, immunohistochemistry, and RNA/DNA sequencing
Jurmeister P, Büttner R, Merkelbach-Bruse S, Kreipe H, Jonigk D, Jochum W, Rodriguez R, Dietel M, Horst D, Hummel M, Kirchner T, Neumann J, Vollbrecht C, Jöhrens K, Aust D, Behnke A, Stenzinger A, Penzel R, Endris V, Schirmacher P, Fisseler-Eckhoff A, von Laffert M. Status quo of ALK testing in lung cancer: results of an EQA scheme based on in-situ hybridization, immunohistochemistry, and RNA/DNA sequencing. Virchows Arch 2021; 479:247-255.
Jun 25, 2021Status quo of ALK testing in lung cancer: results of an EQA scheme based on in-situ hybridization, immunohistochemistry, and RNA/DNA sequencing
Jun 25, 2021Virchows Arch 2021; 479:247-255
Jurmeister Philipp, Büttner Reinhard, Merkelbach-Bruse Sabine, Kreipe Hans, Jonigk Danny, Jochum Wolfram, Rodriguez Regulo, Dietel Manfred, Horst David, Hummel Michael, Kirchner Thomas, Neumann Jens, Vollbrecht Claudia, Jöhrens Korinna, Aust Daniela, Behnke Anke, Stenzinger Albrecht, Penzel Roland, Endris Volker, Schirmacher Peter, Fisseler-Eckhoff Annette, von Laffert Maximilian
Oncogenic hijacking of a developmental transcription factor evokes vulnerability toward oxidative stress in Ewing sarcoma
Marchetto A, Dallmayer M, Romero-Pérez L, Hölting T, Amatruda J, Cossarizza A, Henssen A, Kirchner T, Moretti M, Cidre-Aranaz F, Sannino G, Musa J, Baldauf M, Gerke J, Ohmura S, Orth M, Knott M, Colombo M, Arrigoni C, Bardinet V, Saucier D, Wehweck F, Li J, Stein S, Grünewald T. Oncogenic hijacking of a developmental transcription factor evokes vulnerability toward oxidative stress in Ewing sarcoma. Nat Commun 2020; 11:2423.
May 15, 2020Oncogenic hijacking of a developmental transcription factor evokes vulnerability toward oxidative stress in Ewing sarcoma
May 15, 2020Nat Commun 2020; 11:2423
Marchetto Aruna, Dallmayer Marlene, Romero-Pérez Laura, Hölting Tilman L B, Amatruda James F, Cossarizza Andrea, Henssen Anton G, Kirchner Thomas, Moretti Matteo, Cidre-Aranaz Florencia, Sannino Giuseppina, Musa Julian, Baldauf Michaela, Gerke Julia S, Ohmura Shunya, Orth Martin F, Knott Maximilian M L, Colombo Maria V, Arrigoni Chiara, Bardinet Victor, Saucier David, Wehweck Fabienne S, Li Jing, Stein Stefanie, Grünewald Thomas G P
High Specificity of BCL11B and GLG1 for EWSR1-FLI1 and EWSR1-ERG Positive Ewing Sarcoma
Orth M, Li J, Marchetto A, Henssen A, Özen Ö, Sugita S, Hasegawa T, Kanaseki T, Bertram S, Dirksen U, Hartmann W, Kirchner T, Ohmura S, Gerke J, Cidre-Aranaz F, Hölting T, Dallmayer M, Wehweck F, Paul T, Musa J, Baldauf M, Surdez D, Delattre O, Knott M, Romero-Pérez L, Kasan M, Grünewald T. High Specificity of BCL11B and GLG1 for EWSR1-FLI1 and EWSR1-ERG Positive Ewing Sarcoma. Cancers (Basel) 2020; 12
Mar 10, 2020High Specificity of BCL11B and GLG1 for EWSR1-FLI1 and EWSR1-ERG Positive Ewing Sarcoma
Mar 10, 2020Cancers (Basel) 2020; 12
Orth Martin F, Li Jing, Marchetto Aruna, Henssen Anton G, Özen Özlem, Sugita Shintaro, Hasegawa Tadashi, Kanaseki Takayuki, Bertram Stefanie, Dirksen Uta, Hartmann Wolfgang, Kirchner Thomas, Ohmura Shunya, Gerke Julia S, Cidre-Aranaz Florencia, Hölting Tilman L B, Dallmayer Marlene, Wehweck Fabienne S, Paul Tanja, Musa Julian, Baldauf Michaela, Surdez Didier, Delattre Olivier, Knott Maximilian M L, Romero-Pérez Laura, Kasan Merve, Grünewald Thomas G P
Cooperation of cancer drivers with regulatory germline variants shapes clinical outcomes
Musa J, Stein S, Sannino G, Li J, Romero-Pérez L, Westermann F, Hartmann W, Dirksen U, Gymrek M, Anderson N, Shlien A, Rotblat B, Kirchner T, Delattre O, Baldauf M, Dallmayer M, Marchetto A, Cidre-Aranaz F, Aynaud M, Orth M, Knott M, Mirabeau O, Mazor G, Varon M, Hölting T, Grossetête S, Gartlgruber M, Surdez D, Gerke J, Ohmura S, Grünewald T. Cooperation of cancer drivers with regulatory germline variants shapes clinical outcomes. Nat Commun 2019; 10:4128.
Sep 11, 2019Cooperation of cancer drivers with regulatory germline variants shapes clinical outcomes
Sep 11, 2019Nat Commun 2019; 10:4128
Musa Julian, Stein Stefanie, Sannino Giuseppina, Li Jing, Romero-Pérez Laura, Westermann Frank, Hartmann Wolfgang, Dirksen Uta, Gymrek Melissa, Anderson Nathaniel D, Shlien Adam, Rotblat Barak, Kirchner Thomas, Delattre Olivier, Baldauf Michaela, Dallmayer Marlene, Marchetto Aruna, Cidre-Aranaz Florencia, Aynaud Marie-Ming, Orth Martin F, Knott Maximilian M L, Mirabeau Olivier, Mazor Gal, Varon Mor, Hölting Tilman L B, Grossetête Sandrine, Gartlgruber Moritz, Surdez Didier, Gerke Julia S, Ohmura Shunya, Grünewald Thomas G P
Targeting the CALCB/RAMP1 axis inhibits growth of Ewing sarcoma
Dallmayer M, Sannino G, Bach H, Kirchner T, Marchetto A, Orth M, Gerke J, Romero-Pérez L, Wehweck F, Cidre-Aranaz F, Stein S, Knott M, Musa J, Hölting T, Baldauf M, Alba Rubio R, Ohmura S, Li J, Grünewald T. Targeting the CALCB/RAMP1 axis inhibits growth of Ewing sarcoma. Cell Death Dis 2019; 10:116.
Feb 11, 2019Targeting the CALCB/RAMP1 axis inhibits growth of Ewing sarcoma
Feb 11, 2019Cell Death Dis 2019; 10:116
Dallmayer Marlene, Sannino Giuseppina, Bach Horacio, Kirchner Thomas, Marchetto Aruna, Orth Martin F, Gerke Julia S, Romero-Pérez Laura, Wehweck Fabienne S, Cidre-Aranaz Florencia, Stein Stefanie, Knott Max M L, Musa Julian, Hölting Tilman L B, Baldauf Michaela, Alba Rubio Rebeca, Ohmura Shunya, Li Jing, Grünewald Thomas G P
Functional genomics identifies AMPD2 as a new prognostic marker for undifferentiated pleomorphic sarcoma
Orth M, Sannino G, Knott M, Wehweck F, Ohmura S, Li J, Hakozaki M, Kirchner T, Dandekar T, Butt E, Marchetto A, Baldauf M, Dallmayer M, Gerke J, Knösel T, Altendorf-Hofmann A, Musa J, Alba-Rubio R, Stein S, Hölting T, Cidre-Aranaz F, Romero-Pérez L, Grünewald T. Functional genomics identifies AMPD2 as a new prognostic marker for undifferentiated pleomorphic sarcoma. Int J Cancer 2018; 144:859-867.
Dec 4, 2018Functional genomics identifies AMPD2 as a new prognostic marker for undifferentiated pleomorphic sarcoma
Dec 4, 2018Int J Cancer 2018; 144:859-867
Orth Martin F, Sannino Giuseppina, Knott Maximilian M L, Wehweck Fabienne, Ohmura Shunya, Li Jing, Hakozaki Michiyuki, Kirchner Thomas, Dandekar Thomas, Butt Elke, Marchetto Aruna, Baldauf Michaela, Dallmayer Marlene, Gerke Julia S, Knösel Thomas, Altendorf-Hofmann Annelore, Musa Julian, Alba-Rubio Rebeca, Stein Stefanie, Hölting Tilman L B, Cidre-Aranaz Florencia, Romero-Pérez Laura, Grünewald Thomas G P
Systematic identification of cancer-specific MHC-binding peptides with RAVEN
Baldauf M, Hasegawa T, Sugimura H, Baumhoer D, Knott M, Sannino G, Marchetto A, Li J, Busch D, Feuchtinger T, Ohmura S, Orth M, Thiel U, Kirchner T, Sugita S, Özen Ö, Gerke J, Kirschner A, Blaeschke F, Effenberger M, Schober K, Rubio R, Kanaseki T, Kiran M, Dallmayer M, Musa J, Akpolat N, Akatli A, Rosman F, Grünewald T. Systematic identification of cancer-specific MHC-binding peptides with RAVEN. Oncoimmunology 2018; 7:e1481558.
Jul 23, 2018Systematic identification of cancer-specific MHC-binding peptides with RAVEN
Jul 23, 2018Oncoimmunology 2018; 7:e1481558
Baldauf Michaela, Hasegawa Tadashi, Sugimura Haruhiko, Baumhoer Daniel, Knott Maximilian M L, Sannino Giuseppina, Marchetto Aruna, Li Jing, Busch Dirk H, Feuchtinger Tobias, Ohmura Shunya, Orth Martin F, Thiel Uwe, Kirchner Thomas, Sugita Shintaro, Özen Özlem, Gerke Julia S, Kirschner Andreas, Blaeschke Franziska, Effenberger Manuel, Schober Kilian, Rubio Rebeca Alba, Kanaseki Takayuki, Kiran Merve M, Dallmayer Marlene, Musa Julian, Akpolat Nurset, Akatli Ayse N, Rosman Fernando C, Grünewald Thomas G P
Are EWSR1-NFATc2-positive sarcomas really Ewing sarcomas?
Baldauf M, Gerke J, Orth M, Dallmayer M, Baumhoer D, de Alava E, Hartmann W, Kirchner T, Grünewald T. Are EWSR1-NFATc2-positive sarcomas really Ewing sarcomas?. Mod Pathol 2018; 31:997-999.
Jun 12, 2018Are EWSR1-NFATc2-positive sarcomas really Ewing sarcomas?
Jun 12, 2018Mod Pathol 2018; 31:997-999
Baldauf Michaela, Gerke Julia S, Orth Martin F, Dallmayer Marlene, Baumhoer Daniel, de Alava Enrique, Hartmann Wolfgang, Kirchner Thomas, Grünewald Thomas G P
Robust diagnosis of Ewing sarcoma by immunohistochemical detection of super-enhancer-driven EWSR1-ETS targets
Baldauf M, Akatli A, Özen Ö, Dirksen U, Hartmann W, de Alava E, Baumhoer D, Sannino G, Kirchner T, Akpolat N, Li J, Ohmura S, Orth M, Dallmayer M, Marchetto A, Gerke J, Rubio R, Kiran M, Musa J, Knott M, Grünewald T. Robust diagnosis of Ewing sarcoma by immunohistochemical detection of super-enhancer-driven EWSR1-ETS targets. Oncotarget 2017; 9:1587-1601.
Aug 4, 2017Robust diagnosis of Ewing sarcoma by immunohistochemical detection of super-enhancer-driven EWSR1-ETS targets
Aug 4, 2017Oncotarget 2017; 9:1587-1601
Baldauf Michaela, Akatli Ayse N, Özen Özlem, Dirksen Uta, Hartmann Wolfgang, de Alava Enrique, Baumhoer Daniel, Sannino Giuseppina, Kirchner Thomas, Akpolat Nusret, Li Jing, Ohmura Shunya, Orth Martin F, Dallmayer Marlene, Marchetto Aruna, Gerke Julia S, Rubio Rebeca Alba, Kiran Merve M, Musa Julian, Knott Maximilian M L, Grünewald Thomas G P
NGS-based BRCA1/2 mutation testing of high-grade serous ovarian cancer tissue: results and conclusions of the first international round robin trial
Endris V, Weichert W, Dietel M, Höfler G, Jochum W, Büttner R, Kirchner T, Kreipe H, Lehmann U, Jung A, Sabine-Merkelbach-Bruse, Hummel M, Darb-Esfahani S, Lenze D, Möbs M, Penzel R, Pfarr N, Stenzinger A, Schirmacher P. NGS-based BRCA1/2 mutation testing of high-grade serous ovarian cancer tissue: results and conclusions of the first international round robin trial. Virchows Arch 2016; 468:697-705.
Mar 22, 2016NGS-based BRCA1/2 mutation testing of high-grade serous ovarian cancer tissue: results and conclusions of the first international round robin trial
Mar 22, 2016Virchows Arch 2016; 468:697-705
Endris Volker, Weichert Wilko, Dietel Manfred, Höfler Gerald, Jochum Wolfram, Büttner Reinhard, Kirchner Thomas, Kreipe Hans, Lehmann Ulrich, Jung Andreas, Sabine-Merkelbach-Bruse, Hummel Michael, Darb-Esfahani Silvia, Lenze Dido, Möbs Markus, Penzel Roland, Pfarr Nicole, Stenzinger Albrecht, Schirmacher Peter
Anaplastic lymphoma kinase (ALK) gene rearrangement in non-small cell lung cancer (NSCLC): results of a multi-centre ALK-testing
V Laffert M, Wölfel C, Petersen I, Rodriguez R, Jochum W, Bartsch H, Fisseler-Eckhoff A, Berg E, Lenze D, Dietel M, Kirchner T, Jung A, Kerler R, Warth A, Penzel R, Schirmacher P, Jonigk D, Kreipe H, Schildhaus H, Merkelbach-Bruse S, Büttner R, Reu S, Hummel M. Anaplastic lymphoma kinase (ALK) gene rearrangement in non-small cell lung cancer (NSCLC): results of a multi-centre ALK-testing. Lung Cancer 2013; 81:200-6.
May 10, 2013Anaplastic lymphoma kinase (ALK) gene rearrangement in non-small cell lung cancer (NSCLC): results of a multi-centre ALK-testing
May 10, 2013Lung Cancer 2013; 81:200-6
V Laffert Maximilian, Wölfel Cornelius, Petersen Iver, Rodriguez Regulo, Jochum Wolfram, Bartsch Holger, Fisseler-Eckhoff Annette, Berg Erika, Lenze Dido, Dietel Manfred, Kirchner Thomas, Jung Andreas, Kerler Rosi, Warth Arne, Penzel Roland, Schirmacher Peter, Jonigk Danny, Kreipe Hans, Schildhaus Hans-Ulrich, Merkelbach-Bruse Sabine, Büttner Reinhard, Reu Simone, Hummel Michael
p16INK4a is a beta-catenin target gene and indicates low survival in human colorectal tumors
Wassermann S, Kirchner T, Brabletz T, Merkel S, Reu S, Kriegl L, Haynl A, Hlubek F, Horst D, Palmqvist R, Hiendlmeyer E, Scheel S, Jung A. p16INK4a is a beta-catenin target gene and indicates low survival in human colorectal tumors. Gastroenterology 2009; 136:196-205.e2.
Jan 1, 2009p16INK4a is a beta-catenin target gene and indicates low survival in human colorectal tumors
Jan 1, 2009Gastroenterology 2009; 136:196-205.e2
Wassermann Stella, Kirchner Thomas, Brabletz Thomas, Merkel Susanne, Reu Simone, Kriegl Lydia, Haynl Angela, Hlubek Falk, Horst David, Palmqvist Richard, Hiendlmeyer Elke, Scheel Silvio K, Jung Andreas
beta-Catenin regulates the expression of tenascin-C in human colorectal tumors
Beiter K, Hiendlmeyer E, Brabletz T, Hlubek F, Haynl A, Knoll C, Kirchner T, Jung A. beta-Catenin regulates the expression of tenascin-C in human colorectal tumors. Oncogene 2005; 24:8200-4.
Dec 8, 2005beta-Catenin regulates the expression of tenascin-C in human colorectal tumors
Dec 8, 2005Oncogene 2005; 24:8200-4
Beiter Katharina, Hiendlmeyer Elke, Brabletz Thomas, Hlubek Falk, Haynl Angela, Knoll Claudia, Kirchner Thomas, Jung Andreas
Invasion and metastasis in colorectal cancer: epithelial-mesenchymal transition, mesenchymal-epithelial transition, stem cells and beta-catenin
Brabletz T, Hlubek F, Spaderna S, Schmalhofer O, Hiendlmeyer E, Jung A, Kirchner T. Invasion and metastasis in colorectal cancer: epithelial-mesenchymal transition, mesenchymal-epithelial transition, stem cells and beta-catenin. Cells Tissues Organs (Print) 2005; 179:56-65.
Jan 1, 2005Invasion and metastasis in colorectal cancer: epithelial-mesenchymal transition, mesenchymal-epithelial transition, stem cells and beta-catenin
Jan 1, 2005Cells Tissues Organs (Print) 2005; 179:56-65
Brabletz Thomas, Hlubek Falk, Spaderna Simone, Schmalhofer Otto, Hiendlmeyer Elke, Jung Andreas, Kirchner Thomas
Beta-catenin up-regulates the expression of the urokinase plasminogen activator in human colorectal tumors
Hiendlmeyer E, Kirchner T, Brabletz T, Reuning U, van Beest M, Knoll C, Koch C, Dimmler A, Haynl A, Hlubek F, Wassermann S, Regus S, Jung A. Beta-catenin up-regulates the expression of the urokinase plasminogen activator in human colorectal tumors. Cancer Res 2004; 64:1209-14.
Feb 15, 2004Beta-catenin up-regulates the expression of the urokinase plasminogen activator in human colorectal tumors
Feb 15, 2004Cancer Res 2004; 64:1209-14
Hiendlmeyer Elke, Kirchner Thomas, Brabletz Thomas, Reuning Ute, van Beest Moniek, Knoll Claudia, Koch Claudia, Dimmler Arno, Haynl Angela, Hlubek Falk, Wassermann Stella, Regus Susanne, Jung Andreas
T-cell factor-4 frameshift mutations occur frequently in human microsatellite instability-high colorectal carcinomas but do not contribute to carcinogenesis
Ruckert S, Kirchner T, Brabletz T, Rüschoff J, Koch C, Haynl A, Dietmaier W, Beyser K, Oswald U, Brueckl W, Hiendlmeyer E, Jung A. T-cell factor-4 frameshift mutations occur frequently in human microsatellite instability-high colorectal carcinomas but do not contribute to carcinogenesis. Cancer Res 2002; 62:3009-13.
Jun 1, 2002T-cell factor-4 frameshift mutations occur frequently in human microsatellite instability-high colorectal carcinomas but do not contribute to carcinogenesis
Jun 1, 2002Cancer Res 2002; 62:3009-13
Ruckert Stefan, Kirchner Thomas, Brabletz Thomas, Rüschoff Josef, Koch Claudia, Haynl Angela, Dietmaier Wolfgang, Beyser Kurt, Oswald Ursula, Brueckl Wolfgang M, Hiendlmeyer Elke, Jung Andreas