Dr. Elke Scandella
Institute of Immunobiology · Management
Intestinal fibroblastic reticular cell niches control innate lymphoid cell homeostasis and function
Cheng H, Scandella E, Hehlgans T, Pérez Shibayama C, Gil Cruz C, Novkovic M, Onder L, Engetschwiler C, Lütge M, Mörbe U, Ludewig B. Intestinal fibroblastic reticular cell niches control innate lymphoid cell homeostasis and function. Nat Commun 2022; 13:2027.
Apr 19, 2022Intestinal fibroblastic reticular cell niches control innate lymphoid cell homeostasis and function
Apr 19, 2022Nat Commun 2022; 13:2027
Cheng Hung-Wei, Scandella Elke, Hehlgans T, Pérez Shibayama Christian Ivan, Gil Cruz Cristina, Novkovic M, Onder Lucas, Engetschwiler Céline, Lütge Mechthild, Mörbe Urs, Ludewig Burkhard
Viral vector-mediated reprogramming of the fibroblastic tumor stroma sustains curative melanoma treatment
Ring S, Spiegl M, Besse A, Bonilla W, Stemeseder F, Schmidt S, Orlinger K, Krebs P, Ludewig B, Wenger R, Hartmann F, Cupovic J, Onder L, Lütge M, Pérez Shibayama C, Gil Cruz C, Scandella E, De Martin A, Mörbe U, Flatz L. Viral vector-mediated reprogramming of the fibroblastic tumor stroma sustains curative melanoma treatment. Nat Commun 2021; 12:4734.
Aug 5, 2021Viral vector-mediated reprogramming of the fibroblastic tumor stroma sustains curative melanoma treatment
Aug 5, 2021Nat Commun 2021; 12:4734
Ring Sandra, Spiegl Matthias, Besse Andrej, Bonilla Weldy V, Stemeseder Felix, Schmidt Sarah, Orlinger Klaus K, Krebs Philippe, Ludewig Burkhard, Wenger Robert, Hartmann Fabienne, Cupovic Jovana, Onder Lucas, Lütge Mechthild, Pérez Shibayama Christian Ivan, Gil Cruz Cristina, Scandella Elke, De Martin Angelina, Mörbe Urs, Flatz Lukas
Adenovirus vector vaccination reprograms pulmonary fibroblastic niches to support protective inflating memory CD8 T cells
Cupovic J, Klenerman P, Engeler D, Krebs P, Scandella E, Oxenius A, Flatz L, Provine N, De Martin A, Cheng H, Lütge M, Colston J, Onder L, Ring S, Ludewig B. Adenovirus vector vaccination reprograms pulmonary fibroblastic niches to support protective inflating memory CD8 T cells. Nat Immunol 2021; 22:1042-1051.
Jul 15, 2021Adenovirus vector vaccination reprograms pulmonary fibroblastic niches to support protective inflating memory CD8 T cells
Jul 15, 2021Nat Immunol 2021; 22:1042-1051
Cupovic Jovana, Klenerman Paul, Engeler Daniel, Krebs Philippe, Scandella Elke, Oxenius Annette, Flatz Lukas, Provine Nicholas M, De Martin Angelina, Cheng Hung-Wei, Lütge Mechthild, Colston Julia M, Onder Lucas, Ring Sandra, Ludewig Burkhard
Origin and differentiation trajectories of fibroblastic reticular cells in the splenic white pulp
Cheng H, Hehlgans T, Rülicke T, Pfeffer K, Sorg U, Tersteegen A, Miyazaki J, Robinson M, Scandella E, Pikor N, Lütge M, Soneson C, Novkovic M, Onder L, Ludewig B. Origin and differentiation trajectories of fibroblastic reticular cells in the splenic white pulp. Nat Commun 2019; 10:1739.
Apr 15, 2019Origin and differentiation trajectories of fibroblastic reticular cells in the splenic white pulp
Apr 15, 2019Nat Commun 2019; 10:1739
Cheng Hung-Wei, Hehlgans Thomas, Rülicke Thomas, Pfeffer Klaus, Sorg Ursula, Tersteegen Anne, Miyazaki Jun-Ichi, Robinson Mark D, Scandella Elke, Pikor Natalia, Lütge Mechthild, Soneson Charlotte, Novkovic Mario, Onder Lucas, Ludewig Burkhard
Fibroblastic reticular cells initiate immune responses in visceral adipose tissues and secure peritoneal immunity
Pérez Shibayama C, Gommerman J, Scandella E, Robinson M, Soneson C, Mack M, Turley S, Buechler M, López-Macías C, Li C, Novkovic M, Mörbe U, Printz A, Onder L, Cheng H, Gil Cruz C, Ludewig B. Fibroblastic reticular cells initiate immune responses in visceral adipose tissues and secure peritoneal immunity. Sci Immunol 2018; 3
Aug 10, 2018Fibroblastic reticular cells initiate immune responses in visceral adipose tissues and secure peritoneal immunity
Aug 10, 2018Sci Immunol 2018; 3
Pérez Shibayama Christian Ivan, Gommerman Jennifer, Scandella Elke, Robinson Mark D, Soneson Charlotte, Mack Matthias, Turley Shannon J, Buechler Matthew B, López-Macías Constantino, Li Conglei, Novkovic Mario, Mörbe Urs, Printz Andrea, Onder Lucas, Cheng Hung-Wei, Gil Cruz Cristina, Ludewig Burkhard
Oxysterol Sensing through the Receptor GPR183 Promotes the Lymphoid-Tissue-Inducing Function of Innate Lymphoid Cells and Colonic Inflammation
Emgård J, Svensson M, Scandella E, Hepworth M, Huber S, Ludewig B, Peduto L, Villablanca E, Veiga-Fernandes H, Pereira J, Flavell R, Kvedaraite E, Melo-Gonzalez F, Kammoun H, García-Cassani B, Chesné J, Parigi S, Jacob J, Cheng H, Evren E, Das S, Czarnewski P, Sleiers N, Willinger T. Oxysterol Sensing through the Receptor GPR183 Promotes the Lymphoid-Tissue-Inducing Function of Innate Lymphoid Cells and Colonic Inflammation. Immunity 2018; 48:120-132.e8.
Jan 16, 2018Oxysterol Sensing through the Receptor GPR183 Promotes the Lymphoid-Tissue-Inducing Function of Innate Lymphoid Cells and Colonic Inflammation
Jan 16, 2018Immunity 2018; 48:120-132.e8
Emgård Johanna, Svensson Mattias, Scandella Elke, Hepworth Matthew R, Huber Samuel, Ludewig Burkhard, Peduto Lucie, Villablanca Eduardo J, Veiga-Fernandes Henrique, Pereira João P, Flavell Richard A, Kvedaraite Egle, Melo-Gonzalez Felipe, Kammoun Hana, García-Cassani Bethania, Chesné Julie, Parigi Sara M, Jacob Jean-Marie, Cheng Hung-Wei, Evren Elza, Das Srustidhar, Czarnewski Paulo, Sleiers Natalie, Willinger Tim
Lymphatic Endothelial Cells Control Initiation of Lymph Node Organogenesis
Onder L, Scandella E, Sawa S, Mueller C, Gommerman J, Rülicke T, Waisman A, Becher B, Pfeffer K, Hehlgans T, Cheng H, Novkovic M, Pikor N, Mörbe U, Ludewig B. Lymphatic Endothelial Cells Control Initiation of Lymph Node Organogenesis. Immunity 2017; 47:80-92.e4.
Jul 11, 2017Lymphatic Endothelial Cells Control Initiation of Lymph Node Organogenesis
Jul 11, 2017Immunity 2017; 47:80-92.e4
Onder Lucas, Scandella Elke, Sawa Shinichiro, Mueller Christopher G, Gommerman Jennifer, Rülicke Thomas, Waisman Ari, Becher Burkhard, Pfeffer Klaus, Hehlgans Thomas, Cheng Hung-Wei, Novkovic Mario, Pikor Natalia, Mörbe Urs, Ludewig Burkhard
Fibroblastic reticular cells regulate intestinal inflammation via IL-15-mediated control of group 1 ILCs
Gil Cruz C, Scandella E, Ikuta K, Cui G, Abe S, McCoy K, Geuking M, Lang P, Novkovic M, Cheng H, Cupovic J, Chai Q, Onder L, Pérez Shibayama C, Ludewig B. Fibroblastic reticular cells regulate intestinal inflammation via IL-15-mediated control of group 1 ILCs. Nat Immunol 2016; 17:1388-1396.
Oct 31, 2016Fibroblastic reticular cells regulate intestinal inflammation via IL-15-mediated control of group 1 ILCs
Oct 31, 2016Nat Immunol 2016; 17:1388-1396
Gil Cruz Cristina, Scandella Elke, Ikuta Koichi, Cui Guangwei, Abe Shinya, McCoy Kathy D, Geuking Markus B, Lang Philipp A, Novkovic Mario, Cheng Hung-Wei, Cupovic Jovana, Chai Qian, Onder Lucas, Pérez Shibayama Christian Ivan, Ludewig Burkhard
Topological Small-World Organization of the Fibroblastic Reticular Cell Network Determines Lymph Node Functionality
Novkovic M, Turley S, Bocharov G, Stein J, Scandella E, Cremasco V, Bomze D, Abe J, Cupovic J, Onder L, Ludewig B. Topological Small-World Organization of the Fibroblastic Reticular Cell Network Determines Lymph Node Functionality. PLoS Biol 2016; 14:e1002515.
Jul 14, 2016Topological Small-World Organization of the Fibroblastic Reticular Cell Network Determines Lymph Node Functionality
Jul 14, 2016PLoS Biol 2016; 14:e1002515
Novkovic Mario, Turley Shannon J, Bocharov Gennady, Stein Jens V, Scandella Elke, Cremasco Viviana, Bomze David, Abe Jun, Cupovic Jovana, Onder Lucas, Ludewig Burkhard
Lymphotoxin-Dependent B Cell-FRC Crosstalk Promotes De Novo Follicle Formation and Antibody Production following Intestinal Helminth Infection
Dubey L, Lebon L, Mosconi I, Yang C, Scandella E, Ludewig B, Luther S, Harris N. Lymphotoxin-Dependent B Cell-FRC Crosstalk Promotes De Novo Follicle Formation and Antibody Production following Intestinal Helminth Infection. Cell Rep 2016; 15:1527-41.
May 5, 2016Lymphotoxin-Dependent B Cell-FRC Crosstalk Promotes De Novo Follicle Formation and Antibody Production following Intestinal Helminth Infection
May 5, 2016Cell Rep 2016; 15:1527-41
Dubey Lalit Kumar, Lebon Luc, Mosconi Ilaria, Yang Chen-Ying, Scandella Elke, Ludewig Burkhard, Luther Sanjiv A, Harris Nicola L
Fibroblastic reticular cell-derived lysophosphatidic acid regulates confined intranodal T-cell motility
Takeda A, Scandella E, Ludewig B, Ishii S, Aoki J, Suematsu M, Ishii M, Takeda K, Jalkanen S, Miyasaka M, Kikuta J, Hayasaka H, Kobayashi D, Aoi K, Sasaki N, Sugiura Y, Igarashi H, Tohya K, Inoue A, Hata E, Akahoshi N, Umemoto E. Fibroblastic reticular cell-derived lysophosphatidic acid regulates confined intranodal T-cell motility. Elife 2016; 5
Feb 2, 2016Fibroblastic reticular cell-derived lysophosphatidic acid regulates confined intranodal T-cell motility
Feb 2, 2016Elife 2016; 5
Takeda Akira, Scandella Elke, Ludewig Burkhard, Ishii Satoshi, Aoki Junken, Suematsu Makoto, Ishii Masaru, Takeda Kiyoshi, Jalkanen Sirpa, Miyasaka Masayuki, Kikuta Junichi, Hayasaka Haruko, Kobayashi Daichi, Aoi Keita, Sasaki Naoko, Sugiura Yuki, Igarashi Hidemitsu, Tohya Kazuo, Inoue Asuka, Hata Erina, Akahoshi Noriyuki, Umemoto Eiji
Alternative NF-κB signaling regulates mTEC differentiation from podoplanin-expressing presursors in the cortico-medullary junction
Onder L, Waisman A, Becher B, Ledermann B, Mair F, Maier R, Bomze D, Novkovic M, Caviezel-Firner S, Cheng H, Chai Q, Scandella E, Nindl V, Ludewig B. Alternative NF-κB signaling regulates mTEC differentiation from podoplanin-expressing presursors in the cortico-medullary junction. Eur J Immunol 2015
May 14, 2015Alternative NF-κB signaling regulates mTEC differentiation from podoplanin-expressing presursors in the cortico-medullary junction
May 14, 2015Eur J Immunol 2015
Onder Lucas, Waisman Ari, Becher Burkhard, Ledermann Birgit, Mair Florian, Maier Reinhard, Bomze David, Novkovic Mario, Caviezel-Firner Sonja, Cheng Hung-Wei, Chai Qian, Scandella Elke, Nindl Veronika, Ludewig Burkhard
IFN-γ-producing CD4+ T cells promote generation of protective germinal center-derived IgM+ B cell memory against Salmonella Typhi
Pérez Shibayama C, López-Macías C, Isibasi A, Waisman A, Regen T, Scandella E, Onder L, Chai Q, Hisaki E, Cervantes-Barragan L, Pastelin-Palacios R, Gil Cruz C, Ludewig B. IFN-γ-producing CD4+ T cells promote generation of protective germinal center-derived IgM+ B cell memory against Salmonella Typhi. J Immunol 2014; 192:5192-200.
Apr 28, 2014IFN-γ-producing CD4+ T cells promote generation of protective germinal center-derived IgM+ B cell memory against Salmonella Typhi
Apr 28, 2014J Immunol 2014; 192:5192-200
Pérez Shibayama Christian Ivan, López-Macías Constantino, Isibasi Armando, Waisman Ari, Regen Tommy, Scandella Elke, Onder Lucas, Chai Qian, Hisaki Emiliano, Cervantes-Barragan Luisa, Pastelin-Palacios Rodolfo, Gil Cruz Cristina, Ludewig Burkhard
Systemic minor histocompatibility antigen expression in blood endothelial cells prevents T cell-mediated vascular immunopathology
Caviezel-Firner S, Engeler D, Bolinger B, Onder L, Scandella E, Yu M, Kroczek R, Ludewig B. Systemic minor histocompatibility antigen expression in blood endothelial cells prevents T cell-mediated vascular immunopathology. Eur J Immunol 2013; 43:3233-43.
Sep 6, 2013Systemic minor histocompatibility antigen expression in blood endothelial cells prevents T cell-mediated vascular immunopathology
Sep 6, 2013Eur J Immunol 2013; 43:3233-43
Caviezel-Firner Sonja, Engeler Daniel, Bolinger Beatrice, Onder Lucas, Scandella Elke, Yu Meimei, Kroczek Richard A, Ludewig Burkhard
Maturation of lymph node fibroblastic reticular cells from myofibroblastic precursors is critical for antiviral immunity
Chai Q, Hehlgans T, Stein J, Rülicke T, Thiel V, Luther S, Sparwasser T, Danuser R, Cupovic J, Pérez Shibayama C, Gil Cruz C, Scandella E, Onder L, Ludewig B. Maturation of lymph node fibroblastic reticular cells from myofibroblastic precursors is critical for antiviral immunity. Immunity 2013; 38:1013-24.
Apr 25, 2013Maturation of lymph node fibroblastic reticular cells from myofibroblastic precursors is critical for antiviral immunity
Apr 25, 2013Immunity 2013; 38:1013-24
Chai Qian, Hehlgans Thomas, Stein Jens V, Rülicke Thomas, Thiel Volker, Luther Sanjiv A, Sparwasser Tim, Danuser Renzo, Cupovic Jovana, Pérez Shibayama Christian Ivan, Gil Cruz Cristina, Scandella Elke, Onder Lucas, Ludewig Burkhard
Naive B-cell trafficking is shaped by local chemokine availability and LFA-1-independent stromal interactions
Coelho F, Figge M, Sharpe J, Ludewig B, Sailer A, Junt T, Zerwes H, Pieczyk M, Scandella E, Danuser R, Mayer J, Swoger J, Hons M, Soriano S, Natale D, Stein J. Naive B-cell trafficking is shaped by local chemokine availability and LFA-1-independent stromal interactions. Blood 2013; 121:4101-9.
Apr 4, 2013Naive B-cell trafficking is shaped by local chemokine availability and LFA-1-independent stromal interactions
Apr 4, 2013Blood 2013; 121:4101-9
Coelho Fernanda M, Figge Marc Thilo, Sharpe James, Ludewig Burkhard, Sailer Andreas W, Junt Tobias, Zerwes Hans-Günter, Pieczyk Markus, Scandella Elke, Danuser Renzo, Mayer Jürgen, Swoger Jim, Hons Miroslav, Soriano Silvia F, Natale Daniela, Stein Jens V
Endothelial cell-specific lymphotoxin-β receptor signaling is critical for lymph node and high endothelial venule formation.
Onder L, Danuser R, Scandella E, Firner S, Chai Q, Hehlgans T, Stein J, Ludewig B. Endothelial cell-specific lymphotoxin-β receptor signaling is critical for lymph node and high endothelial venule formation. J Exp Med 2013; 210:465-73.
Feb 18, 2013Endothelial cell-specific lymphotoxin-β receptor signaling is critical for lymph node and high endothelial venule formation.
Feb 18, 2013J Exp Med 2013; 210:465-73
Onder Lucas, Danuser Renzo, Scandella Elke, Firner Sonja, Chai Qian, Hehlgans Thomas, Stein Jens V, Ludewig Burkhard
IL-7-producing stromal cells are critical for lymph node remodeling
Onder L, Coles M, Cupedo T, Westermann J, Kaye P, Richie E, Halin C, Hoorweg K, Iolyeva M, Chai Q, Scandella E, Narang P, Ludewig B. IL-7-producing stromal cells are critical for lymph node remodeling. Blood 2012; 120:4675-83.
Sep 6, 2012IL-7-producing stromal cells are critical for lymph node remodeling
Sep 6, 2012Blood 2012; 120:4675-83
Onder Lucas, Coles Mark, Cupedo Tom, Westermann Jürgen, Kaye Paul, Richie Ellen, Halin Cornelia, Hoorweg Kerim, Iolyeva Maria, Chai Qian, Scandella Elke, Narang Priyanka, Ludewig Burkhard
Cooperation of Th1 and Th17 cells determines transition from autoimmune myocarditis to dilated cardiomyopathy
Nindl V, Rülicke T, Rudin M, Kopf M, Di Padova F, Scandella E, Thiel V, Züst R, De Giuli R, Ratering D, Maier R, Ludewig B. Cooperation of Th1 and Th17 cells determines transition from autoimmune myocarditis to dilated cardiomyopathy. Eur J Immunol 2012; 42:2311-21.
Jul 13, 2012Cooperation of Th1 and Th17 cells determines transition from autoimmune myocarditis to dilated cardiomyopathy
Jul 13, 2012Eur J Immunol 2012; 42:2311-21
Nindl Veronika, Rülicke Thomas, Rudin Markus, Kopf Manfred, Di Padova Franco, Scandella Elke, Thiel Volker, Züst Roland, De Giuli Rita, Ratering David, Maier Reinhard, Ludewig Burkhard
Identification of protective B cell antigens of Legionella pneumophila
Weber S, Hilbi H, Ludewig B, Rösli C, Scandella E, Tchang V, Spörri R, Küntzel A, Joller N, Oxenius A. Identification of protective B cell antigens of Legionella pneumophila. J Immunol 2012; 189:841-9.
Jun 13, 2012Identification of protective B cell antigens of Legionella pneumophila
Jun 13, 2012J Immunol 2012; 189:841-9
Weber Stefan S, Hilbi Hubert, Ludewig Burkhard, Rösli Christoph, Scandella Elke, Tchang Vincent S, Spörri Roman, Küntzel Anna Barbara, Joller Nicole, Oxenius Annette