Dr. Christian Ivan Pérez Shibayama
Post Doctoral fellow
scientist (post doc)
Medizinisches Forschungszentrum · Management
Cardiac Fibroblastic Niches in Homeostasis and Inflammation.
Cadosch N, Gil Cruz C, Pérez Shibayama C, Ludewig B. Cardiac Fibroblastic Niches in Homeostasis and Inflammation. Circ Res 2024; 134:1703-1717.
Jun 6, 2024Cardiac Fibroblastic Niches in Homeostasis and Inflammation.
Jun 6, 2024Circ Res 2024; 134:1703-1717
Cadosch Nadine, Gil Cruz Cristina, Pérez Shibayama Christian Ivan, Ludewig Burkhard
Bone morphogenic protein-4 availability in the cardiac microenviroment controls inflammation and fibrosis in autoimmune myocarditis
Pérez Shibayama C, Gil Cruz C, Cadosch N, Lütge M, Cheng H, De Martin A, Frischmann K, Joachimbauer A, Onder L, Papadopoulou I, Papadopoulou C, Ring S, Krebs P, P. Vu V, P. Nägele M, Rosi V, Parianos D, Zsilavecz V, Cooper L, Flammer A, Ruschitzka F, Reiner P, Schmidt D, Ludewig B. Bone morphogenic protein-4 availability in the cardiac microenviroment controls inflammation and fibrosis in autoimmune myocarditis. Nature Cardiovascular Research 2024; volume 3:301-316.
Apr 19, 2024Bone morphogenic protein-4 availability in the cardiac microenviroment controls inflammation and fibrosis in autoimmune myocarditis
Apr 19, 2024Nature Cardiovascular Research 2024; volume 3:301-316
Pérez Shibayama Christian Ivan, Gil Cruz Cristina, Cadosch Nadine, Lütge Mechthild, Cheng Hung-Wei, De Martin Angelina, Frischmann Kira, Joachimbauer Anna, Onder Lucas, Papadopoulou Iliana, Papadopoulou Chrysa, Ring Sandra, Krebs Philippe, P. Vu Vivian, P. Nägele Matthias, Rosi Valentina, Parianos Danae, Zsilavecz Valentin W, Cooper Leslie T., Flammer Andreas, Ruschitzka Frank, Reiner Peter P, Schmidt Dörthe, Ludewig Burkhard
Fibroblastic reticular cells provide a supportive niche for lymph node-resident macrophages.
D'Rozario J, Knoblich K, Lütge M, Pérez Shibayama C, Cheng H, Alexandre Y, Roberts D, Campos J, Dutton E, Suliman M, Denton A, Turley S, Boyd R, Mueller S, Ludewig B, Heng T, Fletcher A. Fibroblastic reticular cells provide a supportive niche for lymph node-resident macrophages. Eur J Immunol 2023; 53:e2250355.
Jul 12, 2023Fibroblastic reticular cells provide a supportive niche for lymph node-resident macrophages.
Jul 12, 2023Eur J Immunol 2023; 53:e2250355
D'Rozario Joshua, Knoblich Konstantin, Lütge Mechthild, Pérez Shibayama Christian Ivan, Cheng Hung-Wei, Alexandre Yannick O, Roberts David J, Campos Joana, Dutton Emma E, Suliman Muath, Denton Alice E, Turley Shannon J, Boyd Richard L, Mueller Scott N, Ludewig Burkhard, Heng Tracy S P, Fletcher Anne L
Conserved stromal-immune cell circuits secure B cell homeostasis and function.
Lütge M, De Martin A, Gil Cruz C, Pérez Shibayama C, Stanossek Y, Onder L, Cheng H, Kurz L, Cadosch N, Soneson C, Robinson M, Stöckli S, Ludewig B, Pikor N. Conserved stromal-immune cell circuits secure B cell homeostasis and function. Nat Immunol 2023
May 18, 2023Conserved stromal-immune cell circuits secure B cell homeostasis and function.
May 18, 2023Nat Immunol 2023
Lütge Mechthild, De Martin Angelina, Gil Cruz Cristina, Pérez Shibayama Christian Ivan, Stanossek Yves, Onder Lucas, Cheng Hung-Wei, Kurz Lisa, Cadosch Nadine, Soneson Charlotte, Robinson Mark D, Stöckli Sandro, Ludewig Burkhard, Pikor Natalia
Fibroblasts tune myocardial inflammation and remodeling
Pérez Shibayama C, Gil Cruz C, Ludewig B. Fibroblasts tune myocardial inflammation and remodeling. Nature Cardiovascular Research 2022; 1:694–695.
Aug 12, 2022Fibroblasts tune myocardial inflammation and remodeling
Aug 12, 2022Nature Cardiovascular Research 2022; 1:694–695
Pérez Shibayama Christian Ivan, Gil Cruz Cristina, Ludewig Burkhard
Intestinal fibroblastic reticular cell niches control innate lymphoid cell homeostasis and function
Cheng H, Scandella E, Hehlgans T, Pérez Shibayama C, Gil Cruz C, Novkovic M, Onder L, Engetschwiler C, Lütge M, Mörbe U, Ludewig B. Intestinal fibroblastic reticular cell niches control innate lymphoid cell homeostasis and function. Nat Commun 2022; 13:2027.
Apr 19, 2022Intestinal fibroblastic reticular cell niches control innate lymphoid cell homeostasis and function
Apr 19, 2022Nat Commun 2022; 13:2027
Cheng Hung-Wei, Scandella Elke, Hehlgans T, Pérez Shibayama Christian Ivan, Gil Cruz Cristina, Novkovic M, Onder Lucas, Engetschwiler Céline, Lütge Mechthild, Mörbe Urs, Ludewig Burkhard
Viral vector-mediated reprogramming of the fibroblastic tumor stroma sustains curative melanoma treatment
Ring S, Spiegl M, Besse A, Bonilla W, Stemeseder F, Schmidt S, Orlinger K, Krebs P, Ludewig B, Wenger R, Hartmann F, Cupovic J, Onder L, Lütge M, Pérez Shibayama C, Gil Cruz C, Scandella E, De Martin A, Mörbe U, Flatz L. Viral vector-mediated reprogramming of the fibroblastic tumor stroma sustains curative melanoma treatment. Nat Commun 2021; 12:4734.
Aug 5, 2021Viral vector-mediated reprogramming of the fibroblastic tumor stroma sustains curative melanoma treatment
Aug 5, 2021Nat Commun 2021; 12:4734
Ring Sandra, Spiegl Matthias, Besse Andrej, Bonilla Weldy V, Stemeseder Felix, Schmidt Sarah, Orlinger Klaus K, Krebs Philippe, Ludewig Burkhard, Wenger Robert, Hartmann Fabienne, Cupovic Jovana, Onder Lucas, Lütge Mechthild, Pérez Shibayama Christian Ivan, Gil Cruz Cristina, Scandella Elke, De Martin Angelina, Mörbe Urs, Flatz Lukas
Fibroblastic reticular cell lineage convergence in Peyer's patches governs intestinal immunity
Prados A, Ludewig B, Koliaraki V, Pérez Shibayama C, Gil Cruz C, Lütge M, Mörbe U, Cheng H, Onder L, Kollias G. Fibroblastic reticular cell lineage convergence in Peyer's patches governs intestinal immunity. Nat Immunol 2021; 22:510-519.
Mar 11, 2021Fibroblastic reticular cell lineage convergence in Peyer's patches governs intestinal immunity
Mar 11, 2021Nat Immunol 2021; 22:510-519
Prados Alejandro, Ludewig Burkhard, Koliaraki Vasiliki, Pérez Shibayama Christian Ivan, Gil Cruz Cristina, Lütge Mechthild, Mörbe Urs, Cheng Hung-Wei, Onder Lucas, Kollias George
Type I interferon signaling in fibroblastic reticular cells prevents exhaustive activation of antiviral CD8 T cells
Pérez Shibayama C, Gil Cruz C, Colston J, Novkovic M, De Martin A, Ring S, Onder L, Cheng H, Lütge M, Islander U, Ludewig B. Type I interferon signaling in fibroblastic reticular cells prevents exhaustive activation of antiviral CD8 T cells. Sci Immunol 2020; 5
Sep 11, 2020Type I interferon signaling in fibroblastic reticular cells prevents exhaustive activation of antiviral CD8 T cells
Sep 11, 2020Sci Immunol 2020; 5
Pérez Shibayama Christian Ivan, Gil Cruz Cristina, Colston Julia, Novkovic Mario, De Martin Angelina, Ring Sandra, Onder Lucas, Cheng Hung-Wei, Lütge Mechthild, Islander Ulrika, Ludewig Burkhard
Remodeling of light and dark zone follicular dendritic cells governs germinal center responses
Pikor N, Onder L, Linterman M, Nagasawa T, Nombela-Arrieta C, Cheng H, Novkovic M, Pérez Shibayama C, Gil Cruz C, Lütge M, Mörbe U, Ludewig B. Remodeling of light and dark zone follicular dendritic cells governs germinal center responses. Nat Immunol 2020; 21:649-659.
May 18, 2020Remodeling of light and dark zone follicular dendritic cells governs germinal center responses
May 18, 2020Nat Immunol 2020; 21:649-659
Pikor Natalia, Onder Lucas, Linterman Michelle A, Nagasawa Takashi, Nombela-Arrieta César, Cheng Hung-Wei, Novkovic Mario, Pérez Shibayama Christian Ivan, Gil Cruz Cristina, Lütge Mechthild, Mörbe Urs, Ludewig Burkhard
Conservation of the OmpC Porin Among Typhoidal and Non-Typhoidal Serovars
Valero-Pacheco N, Klenerman P, Reyes-Sandoval A, Isibasi A, Pastelin-Palacios R, Sánchez-Torres L, Gil Cruz C, Pérez Shibayama C, Kurioka A, Wong-Baeza I, Pérez-Toledo M, Kemlo P, Aldapa-Vega G, Blight J, López-Macías C. Conservation of the OmpC Porin Among Typhoidal and Non-Typhoidal Serovars. Front Immunol 2020; 10:2966.
Jan 9, 2020Conservation of the OmpC Porin Among Typhoidal and Non-Typhoidal Serovars
Jan 9, 2020Front Immunol 2020; 10:2966
Valero-Pacheco Nuriban, Klenerman Paul, Reyes-Sandoval Arturo, Isibasi Armando, Pastelin-Palacios Rodolfo, Sánchez-Torres Luvia E, Gil Cruz Cristina, Pérez Shibayama Christian Ivan, Kurioka Ayako, Wong-Baeza Isabel, Pérez-Toledo Marisol, Kemlo Phillip, Aldapa-Vega Gustavo, Blight Joshua, López-Macías Constantino
Early-life programming of mesenteric lymph node stromal cell identity by the lymphotoxin pathway regulates adult mucosal immunity
Li C, Ludewig B, Martin A, Liao S, He H, Navarre W, Sun T, Rojas O, Korneev K, Brownlie E, Ahmed M, Nguyen A, Lee D, Zhang J, Ward L, Pérez Shibayama C, Lam E, Gommerman J. Early-life programming of mesenteric lymph node stromal cell identity by the lymphotoxin pathway regulates adult mucosal immunity. Sci Immunol 2019; 4
Dec 20, 2019Early-life programming of mesenteric lymph node stromal cell identity by the lymphotoxin pathway regulates adult mucosal immunity
Dec 20, 2019Sci Immunol 2019; 4
Li Conglei, Ludewig Burkhard, Martin Alberto, Liao Shan, He Housheng Hansen, Navarre William, Sun Tian, Rojas Olga, Korneev Kirill V, Brownlie Emma, Ahmed Musaddeque, Nguyen Albert, Lee Dennis, Zhang Jianbo, Ward Lesley A, Pérez Shibayama Christian Ivan, Lam Evelyn, Gommerman Jennifer L
Expression of AXL receptor tyrosine kinase relates to monocyte dysfunction and severity of cirrhosis
Brenig R, Antoniades C, Wendon J, Heim M, Ludewig B, Weston C, Duong F, Semela D, Brand S, Boldanova T, Künzler-Heule P, Cupovic J, Besse L, Pérez Shibayama C, Singanayagam A, Geng A, Triantafyllou E, Pop O, Bernsmeier C. Expression of AXL receptor tyrosine kinase relates to monocyte dysfunction and severity of cirrhosis. Life Sci Alliance 2019; 3
Dec 10, 2019Expression of AXL receptor tyrosine kinase relates to monocyte dysfunction and severity of cirrhosis
Dec 10, 2019Life Sci Alliance 2019; 3
Brenig Robert, Antoniades Charalambos G, Wendon Julia, Heim Markus H, Ludewig Burkhard, Weston Christopher J, Duong François Ht, Semela David, Brand Stephan, Boldanova Tuyana, Künzler-Heule Patrizia, Cupovic Jovana, Besse Lenka, Pérez Shibayama Christian Ivan, Singanayagam Arjuna, Geng Anne, Triantafyllou Evangelos, Pop Oltin, Bernsmeier Christine
Microbiota-derived peptide mimics drive lethal inflammatory cardiomyopathy
Gil Cruz C, Jahns R, Wyss M, Mooser C, Lambrecht B, Maeder M, Rickli H, Flatz L, Eriksson U, Geuking M, McCoy K, Boivin-Jahns V, Slack E, Arnoldini M, Pérez Shibayama C, De Martin A, Ronchi F, Van der Borght K, Niederer R, Onder L, Lütge M, Novkovic M, Nindl V, Ramos G, Ludewig B. Microbiota-derived peptide mimics drive lethal inflammatory cardiomyopathy. Science 2019; 366:881-886.
Nov 15, 2019Microbiota-derived peptide mimics drive lethal inflammatory cardiomyopathy
Nov 15, 2019Science 2019; 366:881-886
Gil Cruz Cristina, Jahns Roland, Wyss Madeleine, Mooser Catherine, Lambrecht Bart N, Maeder Micha, Rickli Hans, Flatz Lukas, Eriksson Urs, Geuking Markus B, McCoy Kathy D, Boivin-Jahns Valérie, Slack Emma M C, Arnoldini Markus, Pérez Shibayama Christian Ivan, De Martin Angelina, Ronchi Francesca, Van der Borght Katrien, Niederer Rebekka, Onder Lucas, Lütge Mechthild, Novkovic Mario, Nindl Veronika, Ramos Gustavo, Ludewig Burkhard
Divergent memory responses driven by adenoviral vectors are impacted by epitope competition
Colston J, Hutchings C, Chinnakannan S, Highton A, Pérez Shibayama C, Ludewig B, Klenerman P. Divergent memory responses driven by adenoviral vectors are impacted by epitope competition. Eur J Immunol 2019
May 20, 2019Divergent memory responses driven by adenoviral vectors are impacted by epitope competition
May 20, 2019Eur J Immunol 2019
Colston Julia M, Hutchings Claire, Chinnakannan Senthil, Highton Andrew, Pérez Shibayama Christian Ivan, Ludewig Burkhard, Klenerman Paul
Fibroblastic reticular cells at the nexus of innate and adaptive immune responses
Pérez Shibayama C, Gil Cruz C, Ludewig B. Fibroblastic reticular cells at the nexus of innate and adaptive immune responses. Immunol Rev 2019; 289:31-41.
May 1, 2019Fibroblastic reticular cells at the nexus of innate and adaptive immune responses
May 1, 2019Immunol Rev 2019; 289:31-41
Pérez Shibayama Christian Ivan, Gil Cruz Cristina, Ludewig Burkhard
Antibodies as biomarker candidates for response and survival to checkpoint inhibitors in melanoma patients
Fässler M, Jörger M, Recher M, Risch L, Güsewell S, Risch M, Speiser D, Ludewig B, Levesque M, Dummer R, Siano M, Krolik M, Diem S, Mangana J, Hasan Ali O, Berner F, Bomze D, Ring S, Niederer R, Gil Cruz C, Pérez Shibayama C, Flatz L. Antibodies as biomarker candidates for response and survival to checkpoint inhibitors in melanoma patients. J Immunother Cancer 2019; 7:50.
Feb 20, 2019Antibodies as biomarker candidates for response and survival to checkpoint inhibitors in melanoma patients
Feb 20, 2019J Immunother Cancer 2019; 7:50
Fässler Mirjam, Jörger Markus, Recher Mike, Risch Lorenz, Güsewell Sabine, Risch Martin, Speiser Daniel E, Ludewig Burkhard, Levesque Mitchell P, Dummer Reinhard, Siano Marco, Krolik Michal, Diem Stefan, Mangana Joanna, Hasan Ali Omar, Berner Fiamma, Bomze David, Ring Sandra, Niederer Rebekka, Gil Cruz Cristina, Pérez Shibayama Christian Ivan, Flatz Lukas
Fibroblastic reticular cells initiate immune responses in visceral adipose tissues and secure peritoneal immunity
Pérez Shibayama C, Gommerman J, Scandella E, Robinson M, Soneson C, Mack M, Turley S, Buechler M, López-Macías C, Li C, Novkovic M, Mörbe U, Printz A, Onder L, Cheng H, Gil Cruz C, Ludewig B. Fibroblastic reticular cells initiate immune responses in visceral adipose tissues and secure peritoneal immunity. Sci Immunol 2018; 3
Aug 10, 2018Fibroblastic reticular cells initiate immune responses in visceral adipose tissues and secure peritoneal immunity
Aug 10, 2018Sci Immunol 2018; 3
Pérez Shibayama Christian Ivan, Gommerman Jennifer, Scandella Elke, Robinson Mark D, Soneson Charlotte, Mack Matthias, Turley Shannon J, Buechler Matthew B, López-Macías Constantino, Li Conglei, Novkovic Mario, Mörbe Urs, Printz Andrea, Onder Lucas, Cheng Hung-Wei, Gil Cruz Cristina, Ludewig Burkhard
Evolution of Salmonella Typhi outer membrane protein-specific T and B cell responses in humans following oral Ty21a vaccination: A randomized clinical trial
Carreño J, Pérez Shibayama C, Gil Cruz C, López-Macías C, Vernazza P, Ludewig B, Albrich W. Evolution of Salmonella Typhi outer membrane protein-specific T and B cell responses in humans following oral Ty21a vaccination: A randomized clinical trial. PloS one 2017; 12:e0178669.
Jun 1, 2017Evolution of Salmonella Typhi outer membrane protein-specific T and B cell responses in humans following oral Ty21a vaccination: A randomized clinical trial
Jun 1, 2017PloS one 2017; 12:e0178669
Carreño Juan Manuel, Pérez Shibayama Christian Ivan, Gil Cruz Cristina, López-Macías Constantino, Vernazza Pietro, Ludewig Burkhard, Albrich Werner
Salmonella Typhi Porins OmpC and OmpF Are Potent Adjuvants for T-Dependent and T-Independent Antigens
Pérez-Toledo M, Bonifaz L, Isibasi A, Cunningham A, Arriaga-Pizano L, Pérez-Tapia S, Becker I, Moreno-Eutimio M, Pérez Shibayama C, Gil Cruz C, Pastelin-Palacios R, Valero-Pacheco N, López-Macías C. Salmonella Typhi Porins OmpC and OmpF Are Potent Adjuvants for T-Dependent and T-Independent Antigens. Front Immunol 2017; 8:230.
Mar 9, 2017Salmonella Typhi Porins OmpC and OmpF Are Potent Adjuvants for T-Dependent and T-Independent Antigens
Mar 9, 2017Front Immunol 2017; 8:230
Pérez-Toledo Marisol, Bonifaz Laura C, Isibasi Armando, Cunningham Adam F, Arriaga-Pizano Lourdes, Pérez-Tapia Sonia Mayra, Becker Ingeborg, Moreno-Eutimio Mario A, Pérez Shibayama Christian Ivan, Gil Cruz Cristina, Pastelin-Palacios Rodolfo, Valero-Pacheco Nuriban, López-Macías Constantino