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Warning symptoms skin: cutaneous manifestation of drug allergy Most cutaneous drug allergies are localized, more rarely, generalized macular, maculopapular or urticarial reactions occur; they are not life-threatening in this form. In case of strong treatment indications, the causative drugs may be continued under appropriate skin care and careful clinical follow-up. Up to 2% of allergic skin reactions to drugs however are severe drug reactions such as Stevens-Johnson syndrome SJS, SJS-TEN overlap, toxic epidermal necrolysis TEN, or DRESS, AGEP or Sweet Syndrome. It is important to recognize the relevant warning signs or clinical clues of these severe drug reactions in order to identify and stop causative drugs, and to start as early as possible skin-directed and appropriate systemic immunosuppressive treatment.