No Effect of Pegylated Interferon-α on Total HIV-1 DNA Load in HIV-1/HCV Coinfected Patients

Publikation

No Effect of Pegylated Interferon-α on Total HIV-1 DNA Load in HIV-1/HCV Coinfected Patients

Wissenschaftlicher Artikel/Review - 25.05.2018

Strouvelle Victoria P, Günthard Huldrych F, Metzner Karin J, Hoffmann Matthias, Darling Katharine, Rauch Andri, Stöckle Marcel, Kouyos Roger D, Kok Yik Lim, Scherrer Alexandra U, Vongrad Valentina, Braun Dominique L, Zurich Primary HIV Infection Study and the Swiss HIV Cohort Study

Zitation

Strouvelle V, Günthard H, Metzner K, Hoffmann M, Darling K, Rauch A, Stöckle M, Kouyos R, Kok Y, Scherrer A, Vongrad V, Braun D, Zurich Primary HIV Infection Study and the Swiss HIV Cohort Study. No Effect of Pegylated Interferon-α on Total HIV-1 DNA Load in HIV-1/HCV Coinfected Patients. J Infect Dis 2018; 217:1883-1888.

Art

Wissenschaftlicher Artikel/Review (Englisch)

Zeitschrift

J Infect Dis 2018; 217

Veröffentlichungsdatum

25.05.2018

eISSN (Online)

1537-6613

Seiten

1883-1888

Kurzbeschreibung/Zielsetzung

Pegylated interferon-alpha (pIFN-α) is suggested to lower human immunodeficiency virus type-1 (HIV-1) DNA load in antiretroviral therapy (ART)-treated patients. We studied kinetics of HIV-1 DNA levels in 40 HIV-1/hepatitis C virus (HCV) coinfected patients, treated with pIFN-α for HCV and categorized into 3 groups according to start of ART: chronic HIV-1 infection (n = 22), acute HIV-1 infection (n = 8), no-ART (n = 10). Total HIV-1 DNA levels in 247 peripheral blood mononuclear cell samples were stable before, during, and after pIFN-α treatment in all groups. Our results question the benefit of pIFN-α as an immunotherapeutic agent for reducing the HIV-1 reservoir.