Genome-wide meta-analysis identifies six novel loci associated with habitual coffee consumption

Publikation

Genome-wide meta-analysis identifies six novel loci associated with habitual coffee consumption

Wissenschaftlicher Artikel/Review - 07.10.2014

Mukamal Kenneth, Liu Yongmei, Danesh John, Rasheed Asif, Mason Marc A, Zonderman Alan B, Franke Lude, Kristal Bruce S, Karjalainen Juha, Reed Danielle R, Westra Harm-Jan, Evans Michele K, Saleheen Danish, Harris Tamara B, Dedoussis George, Curhan Gary, Stumvoll Michael, Beilby John, Houston Denise K, Lorentzon Mattias, Psaty Bruce M, Döring Angela, Heath Andrew C, Montgomery Grant W, Dahmen Norbert, Carithers Teresa, Tucker Katherine L, Ferrucci Luigi, Boyd Heather A, Melbye Mads, Treur Jorien L, Mellström Dan, Hottenga Jouke Jan, Prokopenko Inga, Tönjes Anke, Deloukas Panos, Kanoni Stavroula, Pasquale Louis R, Feenstra Bjarke, Bandinelli Stefania, Caporaso Neil, Grabe Hans Jörgen, Neuhouser Marian L, Wolffenbuttel Bruce Hr, Hu Frank B, Hyppönen Elina, Jarvelin Marjo-Riitta, Cupples L Adrienne, Franks Paul W, Ridker Paul M, van Duijn Cornelia M, Heiss Gerardo, Metspalu Andres, North Kari E, Ingelsson Erik, Nettleton Jennifer A, van Dam Rob M, Vollenweider Peter, Wareham Nicholas J, Ordovas Jose M, Chan Andrew T, Peters Ulrike, Ohlsson Claes, Gieger Christian, Martin Nicholas G, Waldenberger Melanie, Siscovick David S, Raitakari Olli, Eriksson Johan G, Mitchell Paul, Hunter David J, Kraft Peter, Rimm Eric B, Boomsma Dorret I, Borecki Ingrid B, Loos Ruth Jf, Chasman Daniel I, Mozaffarian Dariush, Wojczynski Mary K, Vink Jacqueline M, Zhao Jing Hua, Burlutsky George, Lahti Jari, Mikkilä Vera, Lemaitre Rozenn N, Eriksson Joel, Musani Solomon K, Tanaka Toshiko, Geller Frank, Luan Jian'an, Hui Jennie, Mägi Reedik, Dimitriou Maria, Garcia Melissa E, Ho Weang-Kee, Manichaikul Ani, Rawal Rajesh, Cornelis Marilyn C, Byrne Enda M, Esko Tõnu, Nalls Michael A, Ganna Andrea, Paynter Nina, Monda Keri L, Amin Najaf, Fischer Krista, Renström Frida, Ngwa Julius S, Huikari Ville, Cavadino Alana, Nolte Ilja M, Teumer Alexander, Yu Kai, Marques-Vidal Pedro, Wright Margaret J, Rose Lynda M, Magnusson Patrik Ke, Bastardot François, Kutalik Zoltán, Jacobs David R, Forouhi Nita G, Mihailov Evelin, Lind Lars, Lindgren Cecilia, Michaëlsson Karl, Morris Andrew, Jensen Majken, Khaw Kay-Tee, Luben Robert N, Wang Jie Jin, Männistö Satu, Perälä Mia-Maria, Kähönen Mika, Lehtimäki Terho, Gu Fangyi, Biffar Reiner, Pedersen Nancy L, Couper David, Oostra Ben A, Hofman Albert, Ikram Mohammad Arfan, Tiemeier Henning W, Uitterlinden André G, van Rooij Frank Ja, Barroso Inês, Johansson Ingegerd, Xue Luting, Kaakinen Marika, Milani Lili, Power Chris, Snieder Harold, Stolk Ronald P, Baumeister Sebastian E, Viikari Jorma

Zitation

Mukamal K, Liu Y, Danesh J, Rasheed A, Mason M, Zonderman A, Franke L, Kristal B, Karjalainen J, Reed D, Westra H, Evans M, Saleheen D, Harris T, Dedoussis G, Curhan G, Stumvoll M, Beilby J, Houston D, Lorentzon M, Psaty B, Döring A, Heath A, Montgomery G, Dahmen N, Carithers T, Tucker K, Ferrucci L, Boyd H, Melbye M, Treur J, Mellström D, Hottenga J, Prokopenko I, Tönjes A, Deloukas P, Kanoni S, Pasquale L, Feenstra B, Bandinelli S, Caporaso N, Grabe H, Neuhouser M, Wolffenbuttel B, Hu F, Hyppönen E, Jarvelin M, Cupples L, Franks P, Ridker P, van Duijn C, Heiss G, Metspalu A, North K, Ingelsson E, Nettleton J, van Dam R, Vollenweider P, Wareham N, Ordovas J, Chan A, Peters U, Ohlsson C, Gieger C, Martin N, Waldenberger M, Siscovick D, Raitakari O, Eriksson J, Mitchell P, Hunter D, Kraft P, Rimm E, Boomsma D, Borecki I, Loos R, Chasman D, Mozaffarian D, Wojczynski M, Vink J, Zhao J, Burlutsky G, Lahti J, Mikkilä V, Lemaitre R, Eriksson J, Musani S, Tanaka T, Geller F, Luan J, Hui J, Mägi R, Dimitriou M, Garcia M, Ho W, Manichaikul A, Rawal R, Cornelis M, Byrne E, Esko T, Nalls M, Ganna A, Paynter N, Monda K, Amin N, Fischer K, Renström F, Ngwa J, Huikari V, Cavadino A, Nolte I, Teumer A, Yu K, Marques-Vidal P, Wright M, Rose L, Magnusson P, Bastardot F, Kutalik Z, Jacobs D, Forouhi N, Mihailov E, Lind L, Lindgren C, Michaëlsson K, Morris A, Jensen M, Khaw K, Luben R, Wang J, Männistö S, Perälä M, Kähönen M, Lehtimäki T, Gu F, Biffar R, Pedersen N, Couper D, Oostra B, Hofman A, Ikram M, Tiemeier H, Uitterlinden A, van Rooij F, Barroso I, Johansson I, Xue L, Kaakinen M, Milani L, Power C, Snieder H, Stolk R, Baumeister S, Viikari J. Genome-wide meta-analysis identifies six novel loci associated with habitual coffee consumption. Mol Psychiatry 2014; 20:647-656.

Art

Wissenschaftlicher Artikel/Review (Englisch)

Zeitschrift

Mol Psychiatry 2014; 20

Veröffentlichungsdatum

07.10.2014

eISSN (Online)

1476-5578

Seiten

647-656

Kurzbeschreibung/Zielsetzung

Coffee, a major dietary source of caffeine, is among the most widely consumed beverages in the world and has received considerable attention regarding health risks and benefits. We conducted a genome-wide (GW) meta-analysis of predominately regular-type coffee consumption (cups per day) among up to 91,462 coffee consumers of European ancestry with top single-nucleotide polymorphisms (SNPs) followed-up in ~30 062 and 7964 coffee consumers of European and African-American ancestry, respectively. Studies from both stages were combined in a trans-ethnic meta-analysis. Confirmed loci were examined for putative functional and biological relevance. Eight loci, including six novel loci, met GW significance (log10Bayes factor (BF)>5.64) with per-allele effect sizes of 0.03-0.14 cups per day. Six are located in or near genes potentially involved in pharmacokinetics (ABCG2, AHR, POR and CYP1A2) and pharmacodynamics (BDNF and SLC6A4) of caffeine. Two map to GCKR and MLXIPL genes related to metabolic traits but lacking known roles in coffee consumption. Enhancer and promoter histone marks populate the regions of many confirmed loci and several potential regulatory SNPs are highly correlated with the lead SNP of each. SNP alleles near GCKR, MLXIPL, BDNF and CYP1A2 that were associated with higher coffee consumption have previously been associated with smoking initiation, higher adiposity and fasting insulin and glucose but lower blood pressure and favorable lipid, inflammatory and liver enzyme profiles (P<5 × 10(-8)).Our genetic findings among European and African-American adults reinforce the role of caffeine in mediating habitual coffee consumption and may point to molecular mechanisms underlying inter-individual variability in pharmacological and health effects of coffee.