Publikation
Hepatosplenic T-cell lymphoma in a patient with Crohn's disease
Wissenschaftlicher Artikel/Review - 01.07.2009
Beigel Florian, Jürgens Matthias, Tillack Cornelia, Subklewe Marion, Mayr Doris, Göke Burkhard, Brand Stephan, Ochsenkühn Thomas
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Kurzbeschreibung/Zielsetzung
BACKGROUND
A 58-year-old man who had a 35-year history of Crohn's disease presented to our IBD center with a disease flare, pararectal fistulas and abscess formation. The patient had previously undergone ileocolic resection for a stenosis and his abscesses had been treated by surgical drainage. He had been taking azathioprine therapy for approximately 5.5 years and had received high-dose steroids. He had also previously taken metronidazole and antihypertensive medications.
INVESTIGATIONS
Physical examination, laboratory investigations including hemoglobin levels and white blood cell counts, genetic testing, CT, bone-marrow biopsy, immunophenotyping by fluorescence-activated cell sorting, polymerase chain reaction analyses, fluorescence in situ hybridization, sputum culture and diagnostic splenectomy.
DIAGNOSIS
Hepatosplenic T-cell lymphoma.
MANAGEMENT
Splenectomy, antibiotic therapy and chemotherapy with cyclophosphamide.