Vitamin E inhibits proliferation of human Tenon's capsule fibroblasts in vitro

Publikation

Vitamin E inhibits proliferation of human Tenon's capsule fibroblasts in vitro

Wissenschaftlicher Artikel/Review - 01.01.1996

Haas A L, Boscoboinik D, Mojon Daniel, Böhnke M, Azzi A

Bereiche

Augenklinik

PubMed

8829174

Zitation

Haas A, Boscoboinik D, Mojon D, Böhnke M, Azzi A. Vitamin E inhibits proliferation of human Tenon's capsule fibroblasts in vitro. Ophthalmic research 1996; 28:171-5.

Art

Wissenschaftlicher Artikel/Review (Englisch)

Zeitschrift

Ophthalmic research 1996; 28

Veröffentlichungsdatum

01.01.1996

ISSN (Druck)

0030-3747

Seiten

171-5

Kurzbeschreibung/Zielsetzung

Failure of glaucoma surgery is mostly due to fibrocellular scar formation, derived from Tenon's capsule fibroblasts. In high-risk cases, postoperative Tenon's capsule fibroblast proliferation is inhibited by mitomycin C or 5-fluorouracil. Toxicity to other ocular cell types and the risk of ocular hypotony limits the use of these agents. We have found that d-alpha-tocopherol (vitamin E) was able to inhibit proliferation of in vitro human Tenon's capsule fibroblasts obtained from seven different donors. At 48 h, inhibition of cell proliferation was 30-78% (mean 60%) for 50 microM d-alpha-tocopherol and 46-97% (mean 77%) for 100 microM d-alpha-tocopherol. This inhibition was statistically significant. No cytotoxic effects were observed.