Control of coronavirus infection through plasmacytoid dendritic-cell-derived type I interferon

Publikation

Control of coronavirus infection through plasmacytoid dendritic-cell-derived type I interferon

Wissenschaftlicher Artikel/Review - 01.02.2007

Cervantes-Barragan Luisa, Züst Roland, Weber Friedemann, Spiegel Martin, Lang Karl S, Akira Shizuo, Thiel Volker, Ludewig Burkhard

Zitation

Cervantes-Barragan L, Züst R, Weber F, Spiegel M, Lang K, Akira S, Thiel V, Ludewig B. Control of coronavirus infection through plasmacytoid dendritic-cell-derived type I interferon. Blood 2007; 109:1131-7.

Art

Wissenschaftlicher Artikel/Review (Englisch)

Zeitschrift

Blood 2007; 109

Veröffentlichungsdatum

01.02.2007

ISSN (Druck)

0006-4971

Seiten

1131-7

Kurzbeschreibung/Zielsetzung

This study demonstrates a unique and crucial role of plasmacytoid dendritic cells (pDCs) and pDC-derived type I interferons (IFNs) in the pathogenesis of mouse coronavirus infection. pDCs controlled the fast replicating mouse hepatitis virus (MHV) through the immediate production of type I IFNs. Recognition of MHV by pDCs was mediated via TLR7 ensuring a swift IFN-alpha production following encounter with this cytopathic RNA virus. Furthermore, the particular type I IFN response pattern was not restricted to the murine coronavirus, but was also found in infection with the highly cytopathic human severe acute respiratory syndrome (SARS) coronavirus. Taken together, our results suggest that rapid production of type I IFNs by pDCs is essential for the control of potentially lethal coronavirus infections.