Publikation
The swiss transplant cohort study: lessons from the first 6 years
Wissenschaftlicher Artikel/Review - 01.06.2015
Christoph Berger, Mueller Nicolas J, Maja Weisser, Van Delden Christian, Nadal David, Meylan Pascal, Manuel Oriol, Khanna Nina, Hoffmann Matthias, Hirsch Hans H, Garzoni Christian, Egli Adrian, Cusini Alexia, Boggian Katia, Bochud Pierre-Yves, Transplant Infectious Diseases Working Group, Swiss Transplant Cohort Study
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Prospective cohort studies significantly contribute to answering specific research questions in a defined population. Since 2008, the Swiss Transplant Cohort Study (STCS) systematically enrolled >95 % of all transplant recipients in Switzerland, collecting predefined data at determined time points. Designed as an open cohort, the STCS has included >3900 patients to date, with a median follow-up of 2.96 years (IQR 1.44-4.73). This review highlights some relevant findings in the field of transplant-associated infections gained by the STCS so far. Three key general aspects have crystallized: (i) Well-run cohort studies are a powerful tool to conduct genetic studies, which are crucially dependent on a meticulously described phenotype. (ii) Long-term real-life observations are adding a distinct layer of information that cannot be obtained during randomized studies. (iii) The systemic collection of data, close interdisciplinary collaboration, and continuous analysis of some key outcome data such as infectious diseases endpoints can improve patient care.