Cellular immune responses and disease control in acute AIDS-associated Kaposi's sarcoma

Publikation

Cellular immune responses and disease control in acute AIDS-associated Kaposi's sarcoma

Wissenschaftlicher Artikel/Review - 10.09.2009

Bihl Florian, Mueller Nicolas J, Brander Christian, Flepp Markus, Speck Roberto F, Nadal David, Trojan Andreas, Bertisch Barbara, Henry Leah M, Chisholm John V, Christoph Berger, Swiss HIV Cohort Study

Zitation

Bihl F, Mueller N, Brander C, Flepp M, Speck R, Nadal D, Trojan A, Bertisch B, Henry L, Chisholm J, Christoph B, Swiss HIV Cohort Study. Cellular immune responses and disease control in acute AIDS-associated Kaposi's sarcoma. AIDS 2009; 23:1918-22.

Art

Wissenschaftlicher Artikel/Review (Englisch)

Zeitschrift

AIDS 2009; 23

Veröffentlichungsdatum

10.09.2009

eISSN (Online)

1473-5571

Seiten

1918-22

Kurzbeschreibung/Zielsetzung

Kaposi's sarcoma-associated herpesvirus (KSHV) specific T cell responses and KSHV viremia were analyzed in seven HIV-infected patients with active Kaposi's sarcoma lesions who initiated highly active antiretroviral therapy, and were compared between patients with improved Kaposi's sarcoma and those with progressive Kaposi's sarcoma requiring further systemic chemotherapy. Patients with controlled Kaposi's sarcoma disease demonstrated undetectable Kaposi's sarcoma viremia together with KSHV-specific CD8 T cells secreting interferon-gamma and tumor necrosis factor-alpha, whereas progressors showed increasing viremia with weak or no T-cell responses. These data point toward a potential role of KSHV-specific immunity in the control of AIDS-associated Kaposi's sarcoma.