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The International Conference on Innovative Approaches in Head and Neck Oncology is a biennial joint meeting under the auspices of the European Society for Radiotherapy and Oncology, the European Head and Neck Society and the European Society of Medical Oncology. The conference focuses on recent developments in head and neck oncology. The main topics of this year were new insights in the epidemiology of head and neck cancer, the emerging role of human papillomavirus in head and neck cancer, update on randomized trials and new management approaches. The format of the meeting included invited key note lectures, interactive symposia, updates on large randomized trials, proffered paper sessions, poster presentations and tumor boards. The meeting was very well balanced, with abundant information and opportunities for interdisciplinary interaction.